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<Provider Id="sundheddkcms"> <Item Id="{DA70B1EE-64FD-4845-B8B6-EA2925908EC5}" Name="lungekraeft" Type="LHContentPage" ParentProviderId="sundheddkcms" ParentItemId="{0DE7FAD1-330A-464D-B95D-C4D9D87B8EB6}" SortOrder="300" PublishDate="2008-10-16T14:36:00" DeleteDate="2999-12-31T00:00:00" PotItemType=""> <Content> <HtmlField Name="PageContent"><![CDATA[<h2>Diagnose</h2> <h3>Diagnostiske kriterier<a href="https://lungemedicin.dk/lungecancer-udredning-ved-mistanke-om-malign-lidelse-i-thorax/" data-type="other-reference" data-value="Lungecancer – Udredning ved mistanke om malign lidelse i thorax. Dansk Lungemedicinsk Selskab. 2020" data-url="https://lungemedicin.dk/lungecancer-udredning-ved-mistanke-om-malign-lidelse-i-thorax/" title="Lungecancer – Udredning ved mistanke om malign lidelse i thorax. Dansk Lungemedicinsk Selskab. 2020">1</a><sup>,</sup><a href="https://www.lungecancer.dk/wp-content/uploads/2020/12/DLCG_visitation_diagn_stadie_AdmGodk141220.pdf" data-type="other-reference" data-value="Dansk Lunge Cancer Gruppe 2020: Visitation, Diagnostik og Stadieinddeling " data-value-piped="Dansk Lunge Cancer Gruppe 2020: Visitation, Diagnostik og Stadieinddeling |https://www.lungecancer.dk/wp-content/uploads/2020/12/DLCG_visitation_diagn_stadie_AdmGodk141220.pdf" data-url="https://www.lungecancer.dk/wp-content/uploads/2020/12/DLCG_visitation_diagn_stadie_AdmGodk141220.pdf" data-pubmedid="undefined" title="Dansk Lunge Cancer Gruppe 2020: Visitation, Diagnostik og Stadieinddeling ">2</a></h3> <ul> <li>Røntgenfund af lungeinfiltrat giver mistanke om diagnosen, histologi giver endelig bekræftelse</li> <li>Målet for udredningen er hurtig histologisk diagnostik og stadieinddeling, som efter indførelsen af "kræftpakker" finder sted subakut på de lokale infiltratudredningsenheder. Se Sundhedsstyrelsens <a rel="noopener noreferrer" href="https://www.sst.dk/da/sygdom-og-behandling/kraeft/pakkeforloeb/~/media/89192ECB2709401CAD8E4BBB0304691E.ashx" target="_blank">pakkeforløb for lungekræft</a></li> </ul> <h3>Sygehistorie</h3> <ul> <li>Diagnosen lungekræft bør overvejes hos enhver ryger med nytilkomne luftvejssymptomer af mere end seks ugers varighed, inklusiv forværring af den sædvanlige tobakshoste</li> <li>Den kliniske præsentation afhænger af lokalisation af primærsvulsten, metastaserne, eventuelle systemiske effekter og ledsagende paraneoplastiske syndromer</li> <li>Symptomatisk lungekræft er ofte uhelbredelig på diagnosetidspunktet</li> <li>Tidlige symptomer er hoste (65 %) og hæmoptyse (35 %), senere kan der ses brystsmerter (50 %), åndenød (60 %), recidiverende lungebetændelse, træthed og vægttab</li> </ul> <h4>Symptomer og tegn på intrathorakal vækst<a href="https://www.lungecancer.dk/wp-content/uploads/2023/06/%C3%85rsrapport-2022-DLCR-offentlig.pdf" data-type="other-reference" data-value="Dansk Lunge Cancer Register Årsrapport 2022" data-url="https://www.lungecancer.dk/wp-content/uploads/2023/06/%C3%85rsrapport-2022-DLCR-offentlig.pdf" title="Dansk Lunge Cancer Register Årsrapport 2022">3</a></h4> <ul> <li>Ca. 40 % af patienterne, som diagnosticeres med lungekræft, præsenterer sig i starten med symptomer og tegn på intratorakal spredning. Intratorakal spredning skyldes direkte indvækst eller spredning via lymfebaner</li> <li>Hæshed som følge af indvækst i nervus recurrens forekommer hos 2-18 %</li> <li>Lammelse af nervus phrenicus kan vise sig som åndenød og ses som højtstående diafragma på rtg. thorax</li> <li>Apical lungetumor (Pancoast's tumor) kan præsentere sig med Horners syndrom og er karakteriseret ved indvækst i plexus brachialis med smerter ud i armen langs de involverede nerverødder</li> <li>Indvækst i brystvæggen kan præsentere sig som vedvarende, pleural smerte</li> <li>Pleuraeffusion kan vise sig med åndenød, svækkede lungelyde og dæmpning ved stetoskopi</li> <li>Indvækst i spiserøret kan give dysphagi</li> <li>Vena cava superior obstruktion (Stokes krave) er karakteriseret ved rødme og ødem af ansigt og hals samt dilaterede vener på øvre del af kroppen, skuldrene og armene</li> <li>Selv om perikardial indvækst ofte findes ved autopsi, så er det sjældent, at patienter præsenterer symptomer på perikardieeffusion eller tamponade<a href=" " data-type="journal-reference" data-value="Press OW, Livingston R, Management of malignant pericardial effusion and tamponade.. JAMA 1987;257: 1088-92" data-value-piped="Press OW, Livingston R|Management of malignant pericardial effusion and tamponade.|JAMA|1987|257|1088-92|3806903" data-url="reference-link" data-pubmedid="3806903" title="Press OW, Livingston R, Management of malignant pericardial effusion and tamponade.. JAMA 1987;257: 1088-92">4</a></li> </ul> <h4>Symptomer og tegn på ekstratorakal spredning</h4> <ul> <li>Næsten en tredjedel af patienter med lungekræft har symptomer og tegn på ekstratorakal spredning på diagnosetidspunktet</li> <li>Mest almindelige metastatiske lokalisationer er knogler, lever, modsidige lunge binyrer, lymfeknuder, hjerne og rygmarv</li> <li>Uspecifikke symptomer på ekstratorakal spredning er træthed og vægttab</li> <li>Knoglemetastaser fører ofte til smerter, patologiske frakturer og rammer sædvanligvis ryghvirvlerne, bækken eller den proximale del af de lange rørknogler</li> <li>Palpable hårde lymfeknuder, særligt supraklavikulært, tyder på metastaser</li> <li>Ca. 10 % af patienterne præsenterer sig med hjernemetastaser, som kan give hovedpine, kvalme, opkastninger, fokale neurologiske udfald, kramper, forvirring eller personlighedsændringer</li> <li>Ved leverinvolvering kan patienten have smerter under kurvaturen, appetitløshed, kvalme og levertal kan være forhøjede</li> </ul> <h4>Paraneoplastiske syndromer</h4> <ul> <li>Ekstrapulmonal dysfunktion i organer uden relation til primærtumor eller metastaser</li> <li>Ca. 10 % af patienter med lungekræft udvikler systemiske symptomer, som skyldes paraneoplastiske syndromer. Dette skyldes frigivelse af bioaktive stoffer produceret af selve tumoren</li> <li>Symptomerne kan optræde både før, samtidig med og efter at diagnosen er stillet</li> <li>Det drejer sig om forskellige endokrine, ossøse, neuromuskulære, kardiovaskulære, hæmatologiske og kutane syndromer</li> </ul> <h3>Kliniske fund</h3> <ul> <li>Kliniske fund varierer og kan evt. mangle helt</li> <li>Centrale tumorer kan give atelektase og poststenotisk recidiverende pneumoni</li> <li>Perifere tumorer giver som regel ingen kliniske fund medmindre de vokser ind i pleura</li> <li>Indvækst i pleura kan give pleuraeffusion og smerter, hvis pleura parietalis involveres</li> <li>Lymfeknudesvulst (collum/fossa supraclavicularis), hepatomegali, Stokes krave og finger clubbing forekommer hos ca. 20 %</li> <li><a href="~/link.aspx?_id=A677176417D048D98B7D090D995561C1&_z=z">Hjernemetastaser</a> kan være første symptom på lungetumor</li> <li>Knoglemetastaser kan give smerter og tværsnitssyndrom</li> <li>Sjældne fund (< 5 %) er Horner's syndrom, Pancoast syndrom, recurrensparese, hudmetastaser</li> </ul> <h3>Supplerende undersøgelser i almen praksis</h3> <ul> <li>Ved mistanke om lungecancer henvises patienten direkte til CT scanning i et kræftpakkeforløb</li> <li>Rtg. thorax er indgangsundersøgelsen i mange tilfælde, men det skal bemærkes, at det kan være normalt i tidligt stadium, særligt ved centralt beliggende svulster. </li> </ul> <h3>Andre undersøgelser på sygehus</h3> <ul> <li>Blodprøver: Hb, L+D, Kreatinin, Calcium, Albumin, levertal</li> </ul> <h4>Billeddiagnostik<a href="https://lungemedicin.dk/lungecancer-udredning-ved-mistanke-om-malign-lidelse-i-thorax/" data-type="other-reference" data-value="Lungecancer – Udredning ved mistanke om malign lidelse i thorax. Dansk Lungemedicinsk Selskab. 2020" data-value-piped="Lungecancer – Udredning ved mistanke om malign lidelse i thorax. Dansk Lungemedicinsk Selskab. 2020|https://lungemedicin.dk/lungecancer-udredning-ved-mistanke-om-malign-lidelse-i-thorax/" data-url="https://lungemedicin.dk/lungecancer-udredning-ved-mistanke-om-malign-lidelse-i-thorax/" data-pubmedid="undefined" title="Lungecancer – Udredning ved mistanke om malign lidelse i thorax. Dansk Lungemedicinsk Selskab. 2020">1</a>,<a href="https://www.lungecancer.dk/wp-content/uploads/2020/12/DLCG_visitation_diagn_stadie_AdmGodk141220.pdf" data-type="other-reference" data-value="Dansk Lunge Cancer Gruppe 2020: Visitation, Diagnostik og Stadieinddeling " data-value-piped="Dansk Lunge Cancer Gruppe 2020: Visitation, Diagnostik og Stadieinddeling |https://www.lungecancer.dk/wp-content/uploads/2020/12/DLCG_visitation_diagn_stadie_AdmGodk141220.pdf" data-url="https://www.lungecancer.dk/wp-content/uploads/2020/12/DLCG_visitation_diagn_stadie_AdmGodk141220.pdf" data-pubmedid="undefined" title="Dansk Lunge Cancer Gruppe 2020: Visitation, Diagnostik og Stadieinddeling ">2</a>,<a href=" " data-type="journal-reference" data-value="Fischer B, Lassen U, Mortensen J, Larsen S, Loft A, Bertelsen A, Ravn J, Clementsen P, Høgholm A, Larsen K, Rasmussen T, Keiding S, Dirksen A, Gerke O, Skov B, Steffensen I, Hansen H, Vilmann P, Jacobsen G, Backer V, Maltbaek N, Pedersen J, Madsen H, Nielsen H, Højgaard L, Preoperative staging of lung cancer with combined PET-CT.. N Engl J Med 2009;361: 32-9" data-value-piped="Fischer B, Lassen U, Mortensen J, Larsen S, Loft A, Bertelsen A, Ravn J, Clementsen P, Høgholm A, Larsen K, Rasmussen T, Keiding S, Dirksen A, Gerke O, Skov B, Steffensen I, Hansen H, Vilmann P, Jacobsen G, Backer V, Maltbaek N, Pedersen J, Madsen H, Nielsen H, Højgaard L|Preoperative staging of lung cancer with combined PET-CT.|N Engl J Med|2009|361|32-9|19571281" data-url="reference-link" data-pubmedid="19571281" title="Fischer B, Lassen U, Mortensen J, Larsen S, Loft A, Bertelsen A, Ravn J, Clementsen P, Høgholm A, Larsen K, Rasmussen T, Keiding S, Dirksen A, Gerke O, Skov B, Steffensen I, Hansen H, Vilmann P, Jacobsen G, Backer V, Maltbaek N, Pedersen J, Madsen H, Nielsen H, Højgaard L, Preoperative staging of lung cancer with combined PET-CT.. N Engl J Med 2009;361: 32-9">5</a></h4> <ul> <li>Rtg. thorax</li> <li>CT af thorax og øvre abdomen med kontrast <ul> <li>Er nødvendig for at evaluere lungeparenkymet, mediastinum, pleura, lever og binyrer</li> <li>Er den bedste undersøgelse i udredningen af hæmoptyse</li> <li>Er nødvendig for TNM-klassifikationen og dermed for behandlingsstrategi</li> </ul> </li> <li>PET-CT</li> <ul> <li>Anvendes til at undersøge for spredning</li> <li>Spredning bør bekræftes ved ultralydvejledt biopsi hvis muligt <a href=" " data-type="journal-reference" data-value="Fischer B, Lassen U, Mortensen J, Larsen S, Loft A, Bertelsen A, Ravn J, Clementsen P, Høgholm A, Larsen K, Rasmussen T, Keiding S, Dirksen A, Gerke O, Skov B, Steffensen I, Hansen H, Vilmann P, Jacobsen G, Backer V, Maltbaek N, Pedersen J, Madsen H, Nielsen H, Højgaard L, Preoperative staging of lung cancer with combined PET-CT.. N Engl J Med 2009;361: 32-9" data-value-piped="Fischer B, Lassen U, Mortensen J, Larsen S, Loft A, Bertelsen A, Ravn J, Clementsen P, Høgholm A, Larsen K, Rasmussen T, Keiding S, Dirksen A, Gerke O, Skov B, Steffensen I, Hansen H, Vilmann P, Jacobsen G, Backer V, Maltbaek N, Pedersen J, Madsen H, Nielsen H, Højgaard L|Preoperative staging of lung cancer with combined PET-CT.|N Engl J Med|2009|361|32-9|19571281" data-url="reference-link" data-pubmedid="19571281" title="Fischer B, Lassen U, Mortensen J, Larsen S, Loft A, Bertelsen A, Ravn J, Clementsen P, Høgholm A, Larsen K, Rasmussen T, Keiding S, Dirksen A, Gerke O, Skov B, Steffensen I, Hansen H, Vilmann P, Jacobsen G, Backer V, Maltbaek N, Pedersen J, Madsen H, Nielsen H, Højgaard L, Preoperative staging of lung cancer with combined PET-CT.. N Engl J Med 2009;361: 32-9">5</a></li> </ul> <li>CT eller MR af cerebrum<a href=" " data-type="journal-reference" data-value="Fischer B, Lassen U, Mortensen J, Larsen S, Loft A, Bertelsen A, Ravn J, Clementsen P, Høgholm A, Larsen K, Rasmussen T, Keiding S, Dirksen A, Gerke O, Skov B, Steffensen I, Hansen H, Vilmann P, Jacobsen G, Backer V, Maltbaek N, Pedersen J, Madsen H, Nielsen H, Højgaard L, Preoperative staging of lung cancer with combined PET-CT.. N Engl J Med 2009;361: 32-9" data-value-piped="Fischer B, Lassen U, Mortensen J, Larsen S, Loft A, Bertelsen A, Ravn J, Clementsen P, Høgholm A, Larsen K, Rasmussen T, Keiding S, Dirksen A, Gerke O, Skov B, Steffensen I, Hansen H, Vilmann P, Jacobsen G, Backer V, Maltbaek N, Pedersen J, Madsen H, Nielsen H, Højgaard L|Preoperative staging of lung cancer with combined PET-CT.|N Engl J Med|2009|361|32-9|19571281" data-url="reference-link" data-pubmedid="19571281" title="Fischer B, Lassen U, Mortensen J, Larsen S, Loft A, Bertelsen A, Ravn J, Clementsen P, Høgholm A, Larsen K, Rasmussen T, Keiding S, Dirksen A, Gerke O, Skov B, Steffensen I, Hansen H, Vilmann P, Jacobsen G, Backer V, Maltbaek N, Pedersen J, Madsen H, Nielsen H, Højgaard L, Preoperative staging of lung cancer with combined PET-CT.. N Engl J Med 2009;361: 32-9">5</a> <ul> <li>Ved symptomer på CNS-affektion</li> </ul> </li> <li>Knoglescintigrafi/PET-scanning <ul> <li>Ved mistanke om knoglemetastaser </li> </ul> </li> </ul> <h4>Invasiv diagnostik</h4> <ul> <li>Bronkoskopi <ul> <li>Diagnosen fås hos 60-90 % ved centrale tumorer, men kun hos ca. 10 % ved perifert beliggende tumorer</li> <li>Undersøgelsen udføres dog også hos alle patienter med perifert lungeinfiltrat for at <ul> <li>udelukke tumor centralt i bronkietræet,</li> <li>foretage bronkial-lavage og børstebiopsi i det relevante segment,</li> <li>få mulighed for stadieinddeling med transbronkial nåleaspirationsbiopsi fra de mediastinale lymfeknuder, som i dag udføres under vejledning af endobronchial ultralyd</li> </ul> </li> <li>Undersøgelsen foregår ambulant og i lokalbedøvelse</li> </ul> </li> <li>Perkutan lungebiopsi <ul> <li>Transtorakal nåleaspirationsbiopsi anvendes ved perifert beliggende tumorer og foregår i lokalbedøvelse under røntgengennemlysning eller CT-vejledt</li> <li>Diagnosen fås hos 60-80 %</li> <li>Falskt negativt svar ses hos ca. 10 %</li> <li>Et uspecifikt benignt resultat bør føre til kirurgisk torakoskopi eller minitorakotomi</li> <li>En sædvanlig komplikation (ca. 15-20 %) er pneumothorax, som dog ikke altid er behandlingskrævende</li> </ul> </li> <li>Pleuracentese <ul> <li>Foretages ved væskeansamling i pleura</li> <li>Væsken undersøges cytologisk</li> <li>Fund af maligne celler udelukker kirurgi og strålebehandling med kurativt formål</li> <li>Negativ undersøgelse udelukker ikke spredning til pleura</li> <li>Ved inkonklusiv cytologi kan histologisk undersøgelse af pleura med torakoskopi eller perkutan pleurabiopsi være nødvendig</li> </ul> </li> <li>Pleurabiopsi <ul> <li>Foretages under røntgengennemlysning i lokalbedøvelse</li> </ul> </li> <li>Torakoskopi <ul> <li>Foretages i lungemedicinsk regi i lokalbedøvelse eller i thoraxkirurgisk regi under generel anæstesi (VATS: video assisted thoracoscopy). Det sidste giver også mulighed for at tage biopsier fra lungevævet</li> <li>Efter undersøgelsen anlægges der et pleuradræn til behandlingen af pneumothorax og såfremt man har påvist malign spredning til pleura, kan der foretages pleurodese mhp at nedsætte risiko for fremtidige pleuraeffusioner</li> </ul> </li> <li>Mediastinoskopi <ul> <li>Foretages i fuld bedøvelse med henblik på histologisk N-klassifikation af lymfeknuder i den forreste del af mediastinum</li> </ul> </li> <li>Ultralydvejledt biopsitagning fra lymfeknuder i mediastinum via bronkietræet (EBUS) <ul> <li>Anvendes i stigende omfang i forbindelse med bronkoskopi til undersøgelse af lymfeknuderne omkring trachea</li> </ul> </li> <li>Ultralydvejledt biopsitagning fra lymfeknuder i mediastinum via øsofagus (EUS) <ul> <li>Kan anvendes, når forstørrede lymfeknuder er utilgængelige for mediastinoskopi, f.eks. når de er lokaliseret i det aorto-pulmonale vindue</li> </ul> </li> <li>Anden biopsitagning <ul> <li>Er relevant ved mistanke om fjernmetastatisk sygdom, f.eks. fra perifere lymfeknuder, hud, knogler, binyrer, andre organer</li> <li>Billeddiagnostik af øvre abdomen og knoglemarvsundersøgelser er derfor faste procedurer ved stadieinddeling af småcellet karcinom</li> </ul> </li> </ul> <h4>Billeddiagnostiske undersøgelser til stadieinddeling</h4> <ul> <li>CT af Thorax og øvre abdomen med kontrast evt. kombineret med PET <ul> <li>Er standardundersøgelsen og indgang til videre invasiv udredning</li> <li>En metode med integreret CT og PET forbedrer den diagnostiske nøjagtighed i stadieinddelingen af ikke-småcellet lungekræft<a href=" " data-type="journal-reference" data-value="Fischer B, Lassen U, Mortensen J, Larsen S, Loft A, Bertelsen A, Ravn J, Clementsen P, Høgholm A, Larsen K, Rasmussen T, Keiding S, Dirksen A, Gerke O, Skov B, Steffensen I, Hansen H, Vilmann P, Jacobsen G, Backer V, Maltbaek N, Pedersen J, Madsen H, Nielsen H, Højgaard L, Preoperative staging of lung cancer with combined PET-CT.. N Engl J Med 2009;361: 32-9" data-value-piped="Fischer B, Lassen U, Mortensen J, Larsen S, Loft A, Bertelsen A, Ravn J, Clementsen P, Høgholm A, Larsen K, Rasmussen T, Keiding S, Dirksen A, Gerke O, Skov B, Steffensen I, Hansen H, Vilmann P, Jacobsen G, Backer V, Maltbaek N, Pedersen J, Madsen H, Nielsen H, Højgaard L|Preoperative staging of lung cancer with combined PET-CT.|N Engl J Med|2009|361|32-9|19571281" data-url="reference-link" data-pubmedid="19571281" title="Fischer B, Lassen U, Mortensen J, Larsen S, Loft A, Bertelsen A, Ravn J, Clementsen P, Høgholm A, Larsen K, Rasmussen T, Keiding S, Dirksen A, Gerke O, Skov B, Steffensen I, Hansen H, Vilmann P, Jacobsen G, Backer V, Maltbaek N, Pedersen J, Madsen H, Nielsen H, Højgaard L, Preoperative staging of lung cancer with combined PET-CT.. N Engl J Med 2009;361: 32-9">5</a></li> </ul> </li> <li>MR <ul> <li>Kan afsløre lokal indvækst i brystvæggen, særligt af apikale og perifere læsioner og ved mediastinal indvækst samt indvækst i rygsøjlen ved mistanke om metastatisk spinalt tværsnitssyndrom</li> </ul> </li> </ul> <h4>Præoperativ undersøgelse af lungefunktionen<a href="https://www.lungecancer.dk/wp-content/uploads/2020/12/DLCG_visitation_diagn_stadie_AdmGodk141220.pdf" data-type="other-reference" data-value="Dansk Lunge Cancer Gruppe 2020: Visitation, Diagnostik og Stadieinddeling " data-value-piped="Dansk Lunge Cancer Gruppe 2020: Visitation, Diagnostik og Stadieinddeling |https://www.lungecancer.dk/wp-content/uploads/2020/12/DLCG_visitation_diagn_stadie_AdmGodk141220.pdf" data-url="https://www.lungecancer.dk/wp-content/uploads/2020/12/DLCG_visitation_diagn_stadie_AdmGodk141220.pdf" data-pubmedid="undefined" title="Dansk Lunge Cancer Gruppe 2020: Visitation, Diagnostik og Stadieinddeling ">2</a></h4> <ul> <li>Respiratoriske problemer er årsag til de væsentligste postoperative komplikationer</li> <li>Spirometri med måling af FEV1 og FVC <ul> <li>Hvis FEV1 er over 60 % af den forventede normalværdi, kan pneumonektomi foretages</li> <li>Hvis værdien er under 60 % foretages måling af diffusionskapacitet og en selektiv lungefunktionsundersøgelse med perfusionsscintigrafi. Ved denne kan man estimere den resterende lungefunktion efter den planlagte operation, som helst skal ligge over 40 % af den forventede værdi for at undgå postoperativ respirationsinsufficiens</li> </ul> </li> <li>Måling af maksimalt oxygenoptagelse under arbejde er også et brugbart parameter og præoperative værdier, som svarer til over 60 % af den forventede værdi indicerer, at patienten vil kunne tåle en pneumonektomi. I praksis svarer det til, at patienten kan klare trappegang til 2. sal uden pause</li> </ul> <h4>Præoperativ undersøgelse af hjertefunktionen<a href="https://www.lungecancer.dk/wp-content/uploads/2020/12/DLCG_visitation_diagn_stadie_AdmGodk141220.pdf" data-type="other-reference" data-value="Dansk Lunge Cancer Gruppe 2020: Visitation, Diagnostik og Stadieinddeling " data-value-piped="Dansk Lunge Cancer Gruppe 2020: Visitation, Diagnostik og Stadieinddeling |https://www.lungecancer.dk/wp-content/uploads/2020/12/DLCG_visitation_diagn_stadie_AdmGodk141220.pdf" data-url="https://www.lungecancer.dk/wp-content/uploads/2020/12/DLCG_visitation_diagn_stadie_AdmGodk141220.pdf" data-pubmedid="undefined" title="Dansk Lunge Cancer Gruppe 2020: Visitation, Diagnostik og Stadieinddeling ">2</a></h4> <ul> <li>Kardiale kontraindikationer er behandlingsresistent hjertesvigt, behandlingsresistent arytmi og/eller akut hjerteinfarkt i løbet af de tre sidste måneder med venstre ventrikels ejektionsfraktion under 40 %</li> <li>Ved kliniske tegn på hjertelidelse skal patienten vurderes kardiologisk</li> </ul> <h4>Molekylærbiologisk diagnostik</h4> <ul> <li>Molekylærbiologiske undersøgelser bidrager til klassificering og behandlingsvalg</li> </ul> <h3>Differentialdiagnoser</h3> <ul> <li><a href="~/link.aspx?_id=86079B2402E549249F904BF67AA8FA3C&_z=z">Tuberkulose</a></li> <li><a href="~/link.aspx?_id=03D3C24F4A1C45EEBE4F0C41637D9447&_z=z">Sarkoidose</a></li> <li>Lungemetastaser</li> <li><a href="~/link.aspx?_id=C0137DD2232646F6AD549B643A06B77F&_z=z">Pneumoni</a></li> </ul> <h2>Behandling</h2> <h3>Behandlingsmål</h3> <ul> <li>Afhængig af sygdomsstadiet, histologi og co-morbiditet iværksættes behandling med enten kurativ eller livsforlængende og palliativ sigte</li> <li>Se <a href="http://www.lungecancer.dk/">Dansk Lunge Cancer Gruppes</a> publikation</li> </ul> <h3>Generelt om behandlingen<a href="%20" title="Hirsch FR, Scagliotti GV, Mulshine JL, Kwon R, Curran WJ Jr, Wu YL, Paz-Ares L, Lung cancer: current therapies and new targeted treatments. Lancet 2017;389: 299-311" data-url="reference-link" data-value-piped="Hirsch FR, Scagliotti GV, Mulshine JL, Kwon R, Curran WJ Jr, Wu YL, Paz-Ares L|Lung cancer: current therapies and new targeted treatments.|Lancet|2017|389|299-311|27574741" data-value="Hirsch FR, Scagliotti GV, Mulshine JL, Kwon R, Curran WJ Jr, Wu YL, Paz-Ares L, Lung cancer: current therapies and new targeted treatments. Lancet 2017;389: 299-311" data-type="journal-reference" data-pubmedid="27574741">6</a></h3> <ul> <li>Kun knap 25 % af patienterne er operable og en del af disse viser sig under operationen også at være inoperable</li> <li>Patienter med ikke-småcellet lungekarcinom bør testes for genmutationer (især EGFR og ALK) og ekspressionsgrad af overflademarkører (programmeret celledød ligand 1 PD-L1)), da dette har indflydelse på, om patienten skal have hhv. targeteret- eller immun-terapi<br> <img alt="Behandling af diss. lungekræft" title="Behandling af diss. lungekræft" src="3B1C7F24A65142A0AB1FA72A6ACFA5F7-480-280" style="width: 480px; height: 280px;" height="280" width="480"></li> <li> Medicinsk kræftbehandling og stråleterapi har begrænset effekt, hvad angår helbredelsen <ul> <li>Der findes dog patienter med både småcellet og ikke-småcellet lungekræft, som har opnået langtidsoverlevelse efter kemo- og stråleterapi<a href="%20" title="The International Adjuvant Lung Cancer Trial Collaborative Group, Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. N Engl J Med 2004;350: 351-360" data-url="reference-link" data-value-piped="The International Adjuvant Lung Cancer Trial Collaborative Group|Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer|N Engl J Med|2004|350|351-360" data-value="The International Adjuvant Lung Cancer Trial Collaborative Group, Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. N Engl J Med 2004;350: 351-360" data-type="journal-reference">7</a></li> </ul> </li> <li> Patienten bør rådgives om rygeophør, da det forbedrer prognosen </li> </ul> <h4>Småcellet lungekarcinom</h4> <ul> <li>Kirurgi <ul> <li>Meget sjældent indiceret, fordi sygdommen ofte er dissemineret ved diagnosetidspunktet<a href="%20" title="Jackman DM, Johnson BE, Small-cell lung cancer. Lancet 2005;366: 1385-96" data-url="reference-link" data-value-piped="Jackman DM, Johnson BE|Small-cell lung cancer|Lancet|2005|366|1385-96" data-value="Jackman DM, Johnson BE, Small-cell lung cancer. Lancet 2005;366: 1385-96" data-type="journal-reference">8</a></li> <li>Hvis kirurgi (T1N0M0) suppleres med adjuverende kemoterapi</li> </ul> </li> <li>Strålebehandling og cytostatika har som regel hurtig effekt <ul> <li>Patienter med lokaliseret sygdom, og som får komplet remission, tilbydes profylaktisk hjernebestråling</li> <li>Ved sygdom begrænset til én hemithorax (begrænset sygdomsstadie) gives sædvanligvis kemoterapi i kombination med strålebehandling mod lunge og mediastinum</li> <li>Ved spredning uden for én hemithorax (udvidet sygdomsstadie) gives primært kun kemoterapi, mens strålebehandling kan komme på tale senere i forløbet mod symptomgivende manifestationer, f.eks. lokalt i thorax, hjerne og knogler </li> </ul> </li> <li> Medicinsk behandling <ul> <li>Mest brugte cytostatika <ul> <li>[DliActiveSubstance;5061;Cisplatin], [DliActiveSubstance;5060;carboplatin], [DliActiveSubstance;6355;etoposid] og [DliActiveSubstance;5928;topotecan] i kombination - dette forlænger levetiden</li> </ul> </li> <li>Objektiv respons opnås hos 80-95 %</li> </ul> </li> </ul> <h4>Ikke-småcellet lungekarcinom</h4> <ul> <li>Kirurgi <ul> <li>Er den vigtigste kurative behandling</li> <li>Kun ca. 25 % er operable efter primær stadieinddeling</li> <li>Af disse er kun ca. 60% radikalt operable ved torakotomi</li> <li>Lobektomi <ul> <li>Er den foretrukne procedure, hvis tumor er begrænset til en enkelt lap</li> <li>Det postoperative forløb er oftest ukompliceret og 30-dagers mortaliteten er under 2 %<a href="https://www.lungecancer.dk/wp-content/uploads/2020/12/DLCG_visitation_diagn_stadie_AdmGodk141220.pdf" data-type="other-reference" data-value="Dansk Lunge Cancer Gruppe 2020: Visitation, Diagnostik og Stadieinddeling " data-url="https://www.lungecancer.dk/wp-content/uploads/2020/12/DLCG_visitation_diagn_stadie_AdmGodk141220.pdf" title="Dansk Lunge Cancer Gruppe 2020: Visitation, Diagnostik og Stadieinddeling ">2</a></li> </ul> </li> <li>Pneumonektomi <ul> <li>Foretages hyppigt af hensyn til radikalitet</li> <li>Præoperativt bør alle patienter vurderes med henblik på pneumonektomi da resektionens omfang aldrig med sikkerhed kan forudses</li> <li>Lobektomi og pneumonektomi kan kombineres med resektion af perikardiet, thoraxvæggen eller diafragma ved indvækst i disse strukturer</li> </ul> </li> <li>Sleeve-lobektomi <ul> <li>Er lobektomi samtidig med resektion af et segment af hoved/stammebronkus</li> <li>Operationen udføres i udvalgte tilfælde ved centrale overlapstumorer som alternativ til pneumonektomi med den fordel at underlappen bevares</li> </ul> </li> <li>Wedge-resektion <ul> <li>Et mindre indgreb, som segmentær og subsegmentær kileresektion og kan anvendes ved mindre tumorer hos patienter med begrænset lungefunktion</li> </ul> </li> <li>Ekstensive resektioner ved N2- og T3-sygdom <ul> <li>Er kun indiceret i udvalgte tilfælde</li> </ul> </li> <li>Carina-resektion <ul> <li>Er pneumonektomi og samtidig fjernelse af carina samt en begrænset del af den modsidige hovedbronkus og trakea</li> <li>Operationen udføres i sjældne tilfælde ved carina-nære tumorer, som er klassificeret som N0 eller N1</li> </ul> </li> <li>Palliativ kirurgi <ul> <li>Kan tilbydes patienter, som er inoperable eller får recidiv</li> <li>Stentbehandling i trakea og hovedbronkus ved afklemning af lumen eller større indvækst</li> <li>Stentbehandling af øsofagus ved spredning til øsofagus eller afklemning af øsofagus af glandelmetastaser</li> <li>Laserbehandling af trachea eller hovedbronkier ved indvækst for at undgå aflukning af lumen eller vækst over på bronkietræet til den modsatte lunge</li> </ul> </li> </ul> </li> <li> Kemoterapi</li> <ul> <li>Ved stadie III-IV og god performance status </li> <li>Remissionsraten ved kemoterapi er lavere end ved småcellet lungekræft; postoperativ adjuverende cisplatin-baseret behandling nedsætter risikoen for recidiv<a href="EditorPage.aspx?da=core&id=%7BDA70B1EE-64FD-4845-B8B6-EA2925908EC5%7D&ed=FIELD969090472&vs&la=da&fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&di=0&hdl=H969090528&us=sitecore%5Canvi&mo&pe=0&fbd=1" title="The International Adjuvant Lung Cancer Trial Collaborative Group, Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. N Engl J Med 2004;350: 351-360" data-url="reference-link" data-value-piped="The International Adjuvant Lung Cancer Trial Collaborative Group|Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer|N Engl J Med|2004|350|351-360" data-value="The International Adjuvant Lung Cancer Trial Collaborative Group, Cisplatin-based adjuvant chemotherapy in patients with completely resected non-small-cell lung cancer. N Engl J Med 2004;350: 351-360" data-type="journal-reference">7</a></li> <li>40-60 % af patienterne opnå en forbigående subjektiv eller objektiv bedring</li> <li>Mest anvendte kemoterapi er behandlingen med to stoffer: <ul> <li>Kombinationer med [DliActiveSubstance;5061;cisplatin] eller [DliActiveSubstance;5060;carboplatin]/[DliActiveSubstance;5117;gemcitabin] og [DliActiveSubstance;5125;vinorelbin]. kemoterapi i kombination med immunterapi anvendes hos en del patienter. Som 2. linje behandling anvendes [DliActiveSubstance;5123;docetaxel] eller antistofbehandling med immunterapi </li> </ul> </li> </ul> <li> Targeteret terapi (primært tyrosinkinasehæmmer)</li> <ul> <li>Tabletbehandling som anvendes til undergrupper af patienter med bestemte mutationer primært i epidermal growth factor-receptoren (EGFR), som ses hos 10-15 % af patienterne - primært kvinder med adenocarcinom, ingen eller beskedent tobaksforbrug.</li> </ul> <li>Immunterapi</li> <ul> <li>Antistoffer som regulerer cytotoksiske T-celler til at være aktive overfor primært kræftceller. Anvendes primært til patienter med høj ekspression af PD-L1. Kan anvendes efter operation for at nedsætte risikoen for recidiv.</li> </ul> <li>Stråleterapi <ul> <li>Har god palliativ effekt på de fleste symptomer ved lungekræft og kan i nogle tilfælde af lokaliseret sygdom (tumorer mindre end 8 cm og uden malign pleuraefusion) være kurativ</li> <li>Tilbydes til patienter med stadie I-III NSCLC, hvor operationsrisikoen er uacceptabel høj. strålebehandlingen kan gives som stereotaksi, dvs med høj præcision i høje doser med få fraktioner </li> <li>Patienter med inoperabel tumor eller recidiv efter operation bør sædvanligvis tilbydes strålebehandling ved symptomer</li> <li>Kan give lindring af hoste, hæmoptyse, dyspnø pga. bronkieobstruktion og smerter fra knoglemetastaser</li> <li>Ved symptomatiske hjernemetastaser anvendes kombination af stråling og højdosis peroral <a href="https://pro.medicin.dk/Laegemiddelgrupper/Grupper/171030">kortikosteroid</a></li> <li>Der gives profylaktisk hjernebestråling af patienter med småcellet lungekarcinom med lokaliseret sygdom og som har opnået komplet remission på kemoterapi og/eller operation<a href="/EditorPage.aspx?da=core&id=%7BDA70B1EE-64FD-4845-B8B6-EA2925908EC5%7D&ed=FIELD969090472&vs&la=da&fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&di=0&hdl=H969090528&us=sitecore%5Canvi&mo&pe=0&fbd=1" title="Jackman DM, Johnson BE, Small-cell lung cancer. Lancet 2005;366: 1385-96" data-url="reference-link" data-value-piped="Jackman DM, Johnson BE|Small-cell lung cancer|Lancet|2005|366|1385-96" data-value="Jackman DM, Johnson BE, Small-cell lung cancer. Lancet 2005;366: 1385-96" data-type="journal-reference">8</a></li> </ul> </li> </ul> <h3>Håndtering i almen praksis</h3> <ul> <li>Operable patienter følges de første 5 år af lungemediciner og/eller onkologer</li> <li>Ikke-kurativt behandlet patienter følges ligeledes lungemediciner/onkolog i et samarbejde med primærsektor og palliativt team</li> </ul> <h3>Råd til patienten</h3> <ul> <li>Bør undgå tobaksrøg</li> <li>Forsøge at holde sig mobil og i god ernæringstilstand. Forsøge at undgå lungeinfektion bl.a. ved <a href="https://pro.medicin.dk/Sygdomme/Sygdom/318661">vaccination mod influenza</a> og <a href="https://pro.medicin.dk/Sygdomme/Sygdom/318662">pneumokokker</a></li> </ul> <h4>Anden palliativ behandling</h4> <ul> <li><a href="~/link.aspx?_id=DA8FF319589D4F6EA37018CA8F890D81&_z=z">af smerte</a></li> <li><a href="~/link.aspx?_id=46F6E55851EC4418A6C478C91DC99534&_z=z">af kvalme og opkast</a></li> <li><a href="~/link.aspx?_id=7BF4932CF16D46F8986887B144A1707F&_z=z">af forstoppelse</a></li> <li><a href="~/link.aspx?_id=109AF5A44B3F4B51A1232C88A690D7DE&_z=z">af malign obstruktion</a></li> <li><a href="~/link.aspx?_id=71359F8E7F7347F0AF7B586F709E5E1C&_z=z">af mundtørhed</a></li> <li><a href="~/link.aspx?_id=5D097F87A9D14640938D380EDD2EF736&_z=z">af kakeksi og dehydrering</a></li> <li><a href="~/link.aspx?_id=4A53DBA3A2BF413FA6D996CD5F4BA144&_z=z">af åndedrætsbesvær</a></li> <li><a href="~/link.aspx?_id=5B6D4EF5C7F5402A87C35C95E633B262&_z=z">af depression</a></li> <li><a href="~/link.aspx?_id=A6ED5F7533DC41BA98628DAB748C490D&_z=z">af angst</a></li> <li><a href="~/link.aspx?_id=E3D20D0E29C040F7AD13AEF89B7F0BCA&_z=z">af delirium</a></li> </ul> <h3>Forebyggende behandling</h3> <ul> <li>Hjælp til rygestop <ul> <li>Hvis man stopper med rygning nedsættes risikoen for at udvikle lungekræft</li> <li>Det er beregnet, at hvis man stopper før 45-50 årsalderen, svinder mere end 90 % af den risiko, som kan tilskrives rygning<a href="%20" title="Peto R, Darby S, Deo H, Solcocks P, Whitley E, Doll R, Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies. BMJ 2000;321: 323-9" data-url="reference-link" data-value-piped="Peto R, Darby S, Deo H, Solcocks P, Whitley E, Doll R|Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies|BMJ|2000|321|323-9" data-value="Peto R, Darby S, Deo H, Solcocks P, Whitley E, Doll R, Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies. BMJ 2000;321: 323-9" data-type="journal-reference">9</a></li> </ul> </li> </ul> <h2>Henvisning</h2> <ul> <li>Ved mistanke om diagnosen, skal der foretages CT-scanning i kræftpakkeforløb. Ved mindste tegn på infiltrat, skal patienten i henhold til intentionen i <a href="https://www.sst.dk/da/sygdom-og-behandling/kraeft/pakkeforloeb/~/media/89192ECB2709401CAD8E4BBB0304691E.ashx">lungekræftpakken</a> fra Sundhedsstyrelsen henvises til det lokale udredningscenter (Infiltratudredningsenheden)</li> </ul> <h2>Opfølgning</h2> <ul> <li>Opfølgning sker i specialafdeling, evt. i samarbejde med praktiserende læge </li> </ul> <h2>Sygdomsforløb, komplikationer og senfølger samt prognose</h2> <h3>Sygdomsforløb</h3> <ul> <li>Lungekræft har en alvorlig prognose, men det ser ud til at overlevelsen i Danmark har bedret sig lidt i løbet af de sidste år</li> <li>På diagnosetidspunktet har 10-15 % af patienterne lokaliseret sygdom. Af disse vil 50 % være døde efter 5 år - selv om operationen var potentielt kurativ</li> <li>Over halvdelen har fjernmetastaser på diagnosetidspunktet</li> <li>Forsøg med screening ved hjælp af CT-scanning viser, at man kan opdage sygdommen tidligt, men det er uafklaret om den tidlige diagnostik forbedrer overlevelsen<a href=" " data-type="journal-reference" data-value="Peto R, Darby S, Deo H, Silcocks P, Whitley E, Doll R, Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies.. BMJ 2000;321: 323-9" data-value-piped="Peto R, Darby S, Deo H, Silcocks P, Whitley E, Doll R|Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies.|BMJ|2000|321|323-9|10926586" data-url="reference-link" data-pubmedid="10926586" title="Peto R, Darby S, Deo H, Silcocks P, Whitley E, Doll R, Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies.. BMJ 2000;321: 323-9">10</a><sup>,</sup><a href=" " data-type="journal-reference" data-value="Saghir Z, Dirksen A, Ashraf H, Bach KS, Brodersen J, Clementsen PF, Døssing M, Hansen H, Kofoed KF, Larsen KR, Mortensen J, Rasmussen JF, Seersholm N, Skov BG, Thorsen H, Tønnesen P, Pedersen JH, CT screening for lung cancer brings forward early disease. The randomised Danish Lung Cancer Screening Trial: status after five annual screening rounds with low-dose CT.. Thorax 2012;67: 296-301" data-value-piped="Saghir Z, Dirksen A, Ashraf H, Bach KS, Brodersen J, Clementsen PF, Døssing M, Hansen H, Kofoed KF, Larsen KR, Mortensen J, Rasmussen JF, Seersholm N, Skov BG, Thorsen H, Tønnesen P, Pedersen JH|CT screening for lung cancer brings forward early disease. The randomised Danish Lung Cancer Screening Trial: status after five annual screening rounds with low-dose CT.|Thorax|2012|67|296-301|22286927" data-url="reference-link" data-pubmedid="22286927" title="Saghir Z, Dirksen A, Ashraf H, Bach KS, Brodersen J, Clementsen PF, Døssing M, Hansen H, Kofoed KF, Larsen KR, Mortensen J, Rasmussen JF, Seersholm N, Skov BG, Thorsen H, Tønnesen P, Pedersen JH, CT screening for lung cancer brings forward early disease. The randomised Danish Lung Cancer Screening Trial: status after five annual screening rounds with low-dose CT.. Thorax 2012;67: 296-301">11</a></li> </ul> <h3>Komplikationer og <a href="~/link.aspx?_id=471CA46BE82C400E9D63538E9BC4CFBC&_z=z">senfølger</a></h3> <ul> <li>Metastaser - ofte til lever, hjerne, knogle, hjerte, abdomen, hud</li> <li>Vena cava superior syndrom (Stokes krave)</li> <li>Parese af n. phrenicus, som giver dyspnø pga. lammelse af diafragma</li> <li>Parese af venstresidig n. recurrens, som giver hæshed pga. lammelse af ve. stemmelæbe</li> <li>Apoplexi-lignende symptomer pga. tryk fra hjernemetastaser evt. akutte blødninger i en hjernemetastase</li> <li>Tværsnitssyndrom på grund af knoglemetastaser</li> </ul> <h3>Prognose<a href="https://www.lungecancer.dk/wp-content/uploads/2020/12/DLCG_visitation_diagn_stadie_AdmGodk141220.pdf" data-type="other-reference" data-value="Dansk Lunge Cancer Gruppe 2020: Visitation, Diagnostik og Stadieinddeling " data-value-piped="Dansk Lunge Cancer Gruppe 2020: Visitation, Diagnostik og Stadieinddeling |https://www.lungecancer.dk/wp-content/uploads/2020/12/DLCG_visitation_diagn_stadie_AdmGodk141220.pdf" data-url="https://www.lungecancer.dk/wp-content/uploads/2020/12/DLCG_visitation_diagn_stadie_AdmGodk141220.pdf" data-pubmedid="undefined" title="Dansk Lunge Cancer Gruppe 2020: Visitation, Diagnostik og Stadieinddeling ">2</a></h3> <ul> <li>1 års overlevelsesraten er ca. 51 % - lidt højere for kvinder sammenlignet med mænd</li> <li>5 års overlevelsesraten har været stigende og er nu ca. 13% for mænd og ca. 19% for kvinder</li> <li>Knap 6% af patienterne med småcellet karcinom overlever i 5 år</li> <li>Faktorer, som påvirker prognosen, er stadium ved diagnosetidspunktet, patientens generelle helbredstilstand, alder, histologitype, tumors vækstrate, terapi og formentlig rygestop</li> <li>5 års overlevelse ved "kurativ" resektion af ikke-små cellet lunge carcinom (NSCLC) er ca. 60 %</li> </ul> <h4>Diagnosetidspunkt</h4> <ul> <li>Der er tidligere påvist en betydelig forsinkelse i udredning og behandling af lungekræft</li> <li>Derfor er der indført <a href="https://www.sst.dk/da/sygdom-og-behandling/kraeft/pakkeforloeb/~/media/89192ECB2709401CAD8E4BBB0304691E.ashx">"lungekræftpakke"</a> mhp hurtig diagnostik og behandling</li> <li>Der foregår forsøg med screening af asymptomatiske rygere eller ex-rygere ved hjælp af lav-dosis CT af thorax og de første resultater viser, at tumorer kan påvises i et tidligt stadium</li> </ul> <h4>Betydningen af rygning</h4> <ul> <li>Ca. otte til ni ud af ti lungekræfttilfælde relateres til rygning</li> <li>Rygestop reducerer i betydelig grad risikoen for udvikling af lungekræft, men reduktionen sker relativt langsomt og kommer nok aldrig ned på samme niveau som hos dem, der aldrig har røget</li> <li>Langtidsoverlevere af rygeinduceret lungekræft er disponeret for andre rygeinducerede kræftformer</li> <li>Der er en dosis-respons sammenhæng mellem rygning og lungekræft <ul> <li>Risiko for lungekræft øges med antal cigaretter, som ryges dagligt, antal rygeår, graden af nikotinafhængighed (dybere inhalation), mængden af tjære og nikotinindhold</li> <li>Mænd, som ryger > 40 cigaretter dagligt, har dobbelt så stor risiko for lungekræft sammenlignet med mænd, som ryger 20 cigaretter dagligt</li> <li>Mænd, som starter før 15-årsalderen, har 4 gange så stor risiko som mænd, der starter efter de fyldte 25 år</li> <li>Det ser ud til, at rygende kvinder er mere følsomme for de lungecarcinogene effekter af tobak end mænd</li> </ul> </li> </ul> <h4>Overlevelse og død</h4> <ul> <li>5 års overlevelse i Danmark for lungekræft er ca. 14 % <ul> <li>overlevelsen fordelt på følgende stadier: <ul> <li>Stadium IA: 60 %</li> <li>Stadium IB: 46 %</li> <li>Stadium IIA: 35 %</li> </ul> </li> </ul> </li> <li>Der dør over 3700 danskere hvert år som følge af lungekræft</li> </ul> <h2>Baggrundsoplysninger</h2> <h3>Definition</h3> <ul> <li>Alle kræftformer i lunger og bronkier </li> <li>Ca. 90 % af alle tilfælde af lungekræft opstår i bronkierne </li> <li>På grund af behandlingen skelnes der mellem småcellet og ikke-småcellet karcinom (pladeepitel karcinom, adenokarcinom og storcellet karcinom)</li> <li>Småcellet lungekræft er den mest aggressive form for lungekræft, som vokser hurtigt og spreder sig tidligt<a href="%20" title="Jackman DM, Johnson BE, Small-cell lung cancer. Lancet 2005;366: 1385-96" data-url="reference-link" data-value-piped="Jackman DM, Johnson BE|Small-cell lung cancer|Lancet|2005|366|1385-96" data-value="Jackman DM, Johnson BE, Small-cell lung cancer. Lancet 2005;366: 1385-96" data-type="journal-reference">8</a> </li> </ul> <h4>Stadieinddeling<a href="https://www.lungecancer.dk/wp-content/uploads/2020/12/DLCG_visitation_diagn_stadie_AdmGodk141220.pdf" data-type="other-reference" data-value="Dansk Lunge Cancer Gruppe 2020: Visitation, Diagnostik og Stadieinddeling " data-url="https://www.lungecancer.dk/wp-content/uploads/2020/12/DLCG_visitation_diagn_stadie_AdmGodk141220.pdf" title="Dansk Lunge Cancer Gruppe 2020: Visitation, Diagnostik og Stadieinddeling ">2</a></h4> <ul> <li>Bygger på TNM-klassifikationen <ul> <li>T - oplysninger om primærtumor </li> <li>N - oplysninger om regionale lymfeknuder </li> <li>M - oplysninger om fjernmetastaser</li> </ul> </li> <li>TX <ul> <li>Maligne celler i ekspektoratet uden røntgenologiske eller bronkoskopiske tegn på primærtumor </li> </ul> </li> <li>T0 <ul> <li>Ingen påviselig primær-tumor </li> <li>Tis Carcinoma in situ</li> </ul> </li> <li>T1 <ul> <li>Tumor omgivet af lunge eller visceral pleura, uden bronkoskopisk påviselig invasion mere proksimalt end til lobære bronkus (dvs. ikke ind i hovedbronkus) </li> <li>T1a Tumor <=1 cm i største diameter</li> <li>T1b Tumor 1-2 cm </li> <li>T1c Tumor 2-3 cm</li> </ul> </li> <li>T2 <ul> <li>T2a Tumor 3-4 cm </li> <li>T2b Tumor 4-5 cm</li> </ul> </li> <li>T3 <ul> <li>Tumor 5-7 cm eller en tumor som direkte invaderer en af følgende strukturer: </li> <li>thoraxvæggen (inklusiv sulcus superior tumor), diafragma, nervus phrenicus, mediastinale pleura, parietale pericardium; eller en tumor i hovedbronkus < 2 cm distalt for hovedcarina, men uden involvering af carina </li> <li>eller associeret med atelektase eller obstruktiv pneumonitis af hele lungen; eller én eller flere separate tumores i samme lungelap </li> <li>eller ved bronkoskopi slimhindeforandringer nærmere end 2 cm fra carina, men uden indvækst i carina </li> <li>eller metastase i samme lungelap </li> </ul> </li> <li>T4 <ul> <li>Tumor >7 cm</li> <li>eller vokser ind i en af følgende strukturer: mediastinum, hjertet, store kar, trachea, nervus recurrens, oesophagus, vertebrae, hovedcarina, eller én eller flere separate tumores i en anden ipsilateral lungelap</li> </ul> </li> <li>N (Regionale Lymfeknuder) </li> <li>NX Regionale lymfeknuder kan ikke vurderes </li> <li>N0 <ul> <li>Ingen metastaser i regionale lymfeknuder </li> </ul> </li> <li>N1 <ul> <li>Metastaser til ipsilaterale peribronkiale og/eller ipsilaterale hilære lymfeknuder og intrapulmonale lymfeknuder, herunder involvering ved direkte udbredelse </li> </ul> </li> <li>N2 <ul> <li>Metastaser til ipsilaterale mediastinale og/eller subkarinale lymfeknuder </li> </ul> </li> <li>N3 <ul> <li>Metastaser i kontralaterale mediastinale lymfeknuder, kontralaterale hilære, ipsilaterale eller kontralaterale scalener- eller supraklavikulære lymfeknuder</li> </ul> </li> <li>Metastaser </li> <li>MX metastaser kan ikke vurderes </li> <li>M0 ingen metastaser </li> <li>M1a Én eller flere separate tumores i en kontralateral lungelap; tumor med pleurale knuder eller malign pleural (eller pericardiel) effusion </li> <li>M1b Én ekstrathorakale metastaser</li> <li>M1c Flere ekstrathorakale metastaser </li> </ul> <p>Tabel, Stadiegruppering<br> i henhold til 2017-klassifikationen (8. udgave)</p> <table> <tbody> <tr> <td><strong>T/M</strong></td> <td><strong>N0</strong></td> <td><strong>N1</strong></td> <td><strong>N2</strong></td> <td><strong>N3</strong></td> </tr> <tr> <td>Tis</td> <td>0</td> <td>-</td> <td>-</td> <td>-</td> </tr> <tr> <td>T1a*</td> <td>IA1*</td> <td>IIB</td> <td>IIIA</td> <td>IIIB</td> </tr> <tr> <td>T1b*</td> <td>IA2*</td> <td>IIB</td> <td>IIIA</td> <td>IIIB</td> </tr> <tr> <td>T1c*</td> <td>IA3*</td> <td>IIB</td> <td>IIIA</td> <td>IIIB</td> </tr> <tr> <td>T2a*</td> <td>IB</td> <td>IIB</td> <td>IIIA</td> <td>IIIB</td> </tr> <tr> <td>T2b*</td> <td>IIA</td> <td>IIB</td> <td>IIIA</td> <td> IIIB </td> </tr> <tr> <td>T3*</td> <td>IIB</td> <td>IIIA</td> <td>IIIB</td> <td>IIIC*</td> </tr> <tr> <td>T4*</td> <td>IIIA</td> <td>IIIA</td> <td>IIIB</td> <td>IIIC*</td> </tr> <tr> <td>M1a</td> <td>IVA*</td> <td>IVA*</td> <td>IVA*</td> <td>IVA*</td> </tr> <tr> <td>M1b*</td> <td>IVA*</td> <td>IVA*</td> <td>IVA*</td> <td>IVA*</td> </tr> <tr> <td>M1c*</td> <td>IVB*</td> <td>IVB*</td> <td>IVB*</td> <td>IVB*</td> </tr> </tbody> </table> <p>* markerer nye T-, M- og Stadiedefinitioner</p> <h3>Forekomst</h3> <ul> <li>Lungekræft er den førende dødsårsag af kræft blandt mænd og er i flere lande også blevet den hyppigste dødelige kræftform blandt kvinder</li> </ul> <h4>Incidens</h4> <ul> <li>Incidens for primær lungekræft <ul> <li>I Danmark opstår der ca. 5000 nye tilfælde årligt, hvoraf ca. 2400 ses hos mænd</li> <li>Medianalderen på diagnosetidspunktet er ca. 70 år</li> </ul> </li> <li>Incidensen blandt kvinder har været stigende de sidste 50 år, mens den toppede for mændene i midten af 1980'erne</li> </ul> <h3>Ætiologi, patogenese og disponerende faktorer</h3> <ul> <li>Tobaksrygning, især cigaretrygning <ul> <li>er den absolut vigtigste årsag til lungekræft både blandt mænd og kvinder og er ansvarlig for ca. 80-90 % af alle tilfælde</li> <li>Risikoen stiger med det kumulerede tobaksforbrug (angives i pakkeår) og er i gennemsnit ca. 20 gange højere blandt vedvarende rygere sammenlignet med aldrig-rygere</li> <li>Passiv rygning øger også risikoen ca. 1,2-1,5 gange</li> <li>Efter rygestop aftager risikoen gradvist og nærmer sig den lave risiko, som ses blandt aldrig-rygere i løbet af ca. 15 år </li> <li>Incidensraten for adenokarcinomer har været stigende i de sidste 20 år, mens forekomsten af planocellulære karcinomer har været aftagende <ul> <li>Årsagen er formentlig udvikling i cigaretterne: filtercigaretterne, som er de mest almindelige cigaretter i dag har et lavere nikotinindhold, som kompenseres af kemiske tilsætningsstoffer, mere intens rygning, højere glødetemperatur og dermed et større indhold af gasformige carcinogener</li> </ul> </li> </ul> </li> <li>Cigar-, pibe- og vandpibe-rygning er også forbundet med øget risiko for lungekræft, men risikoen er lavere end ved cigaretrygning </li> <li>Stråling, asbest, tungmetaller (nikkel, kadmium, chrom or arsenik) og industrielle carcinogener er også dokumenterede årsagsfaktorer, men mindre vigtige end rygning <ul> <li>Der er holdepunkt for, at ca. 20 % af alle lungekræfttilfælde hos mænd kan være forårsaget af erhvervsmæssig udsættelse for forskellige carcinogener</li> </ul> </li> <li>Andre risikofaktorer er: KOL, tidligere hoved-hals-kræft og høj alder</li> </ul> <h3>Kræfttyper </h3> <ul> <li>På grund af forskelle i behandlingsstrategi opdeles lungekræft i 2 hovedtyper: småcellet og ikke-småcellet lungekræft <ul> <li>Ikke-småcellet karcinom opdeles yderligere i <ul> <li>Adenokarcinom </li> <li>Planocellulært karcinom </li> <li>Storcellet karcinom</li> <li>Carcinoid tumor</li> <li>Bronkoalveolært karcinom </li> </ul> </li> </ul> </li> <li>Adenokarcinom <ul> <li>Udgør i dag ca. 56 % af alle lungekræfttilfælde hos kvinder og 43 % blandt mænd</li> <li>Forekomsten er stigende </li> <li>Det er en histologisk heterogen svulst, som ofte er lokaliseret perifert i lungevævet og metastaserer tidligt. Det er også denne type, som opstår i allerede eksisterende arvæv i lungen f.eks. ved idiopatisk lungefibrose</li> </ul> </li> <li>Planocellulært karcinom <ul> <li>Udgør ca. 13 % blandt kvinder og 24 % blandt mænd</li> <li>Forekomsten er let faldende</li> <li>Er sædvanligvis en centralt lokaliseret endobronkial svulst, som præsenterer sig med hæmoptyse, postobstruktiv pneumoni eller atelektase </li> <li>I forhold til adenokarcinom ses metastaser fra denne type senere i sygdomsforløbet</li> </ul> </li> <li>Småcellet lungekarcinom <ul> <li>Udgør 12-13 % af primære lungesvulster </li> <li>Er klinisk meget aggressiv; er sædvanligvis lokaliseret centralt med betydelig indvækst i mediastinum og er forbundet med tidlige ekstratorakale metastaser og paraneoplastiske syndromer </li> <li>Selv om svulsttypen initialt responderer godt på kemoterapi og stråleterapi, er småcellet lungekarcinom oftest en fremskreden sygdom på diagnosetidspunktet og prognosen er dårlig</li> </ul> </li> <li>Storcellet karcinom <ul> <li>Udgør mindre end 1 % </li> <li>Disse karcinomer optræder som store perifere svulster med tidlig metastasering</li> </ul> </li> <li>Carcinoid tumor <ul> <li>Udgør mindre end 2 %</li> <li>Tilhører gruppen af neuroendokrine tumorer</li> <li>Grupperes ofte sammen med godartet adenomer pga. langsom vækst</li> <li>Præsenterer sig ofte med hoste og hæmoptyse. En del er asymptomatiske. Få har endokrine/neuroendokrine manifestationer </li> <li>Behandling er ofte resektion </li> </ul> </li> <li>Bronkoalveolært karcinom/tidligere alveolecelle carcinom. I dag en undertype af adenocarcinom <ul> </ul> </li> </ul> <h3>ICPC-2</h3> <p>[ICPC]</p> <h3>ICD-10/SKS-koder</h3> <p>[ICD10]</p> <h2>Patientinformation</h2> <h3>Hvad du bør informere patienten om</h3> <ul> <li>Det er aldrig for sent at stoppe med at ryge</li> <li>Fortsat rygning, øger risikoen for nye tilfælde af lungekræft, anden kræftsygdom og hjerte- og lungesygdom</li> <li>Undersøgelser tyder på, at fortsat rygning kan give dårligere effekt af behandling, f.eks. stråleterapi</li> </ul> <h3>Hvad findes af skriftlig patientinformation</h3> <ul> <li><a href="~/link.aspx?_id=048A763EC33043429531A6518C4215CA&_z=z">Hvad du bør vide om lungekræft</a></li> <li><a href="~/link.aspx?_id=5C6719D71803426E9674B6106BC0053E&_z=z">Pleurapunktion og pleuratapning</a></li> <li><a href="~/link.aspx?_id=0B3916172C864991AEC8998A48D3DE56&_z=z">Kemoterapi</a></li> <li><a href="~/link.aspx?_id=692A20120B914CAEB1A2E67C9027F920&_z=z">Strålebehandling</a></li> <li><a href="~/link.aspx?_id=11568BDBE3F44CE49281F9A04A557E9C&_z=z">Strålebehandling mod brysthulen</a></li> <li><a href="~/link.aspx?_id=9959B672959A42C596437D38434BDC10&_z=z">Smerter og smertebehandling ved kræft</a></li> <li><a href="~/link.aspx?_id=612971DED73A413380BE9CD8C017D3C9&_z=z">Information om rygestop</a></li> <li><a href="~/link.aspx?_id=4E664CEE8582496E8ADE34B99D46223A&_z=z">For dig som spiser lidt - kostråd</a></li> <li><a href="~/link.aspx?_id=50219A705D7548DBBD0F6B928DFAD956&_z=z">Senfølger efter cancer</a></li> <li><a href="~/link.aspx?_id=471CA46BE82C400E9D63538E9BC4CFBC&_z=z">Senfølger efter cancer - for sundhedsfaglige</a></li> </ul> <h4>Animationer</h4> <ul> <li><a href="~/link.aspx?_id=5C580C343D8446FF854CA977F8EFD4F3&_z=z">Hvordan fungerer lungerne</a></li> <li><a href="~/link.aspx?_id=0F2EFF1E52D948608DB9333E82E1E781&_z=z">Lungekræft</a></li> <li><a href="~/link.aspx?_id=B2DD5AC876B44613A613DAA1B00BEF27&_z=z">Kemoterapi - cellegiftbehandling</a></li> <li><a href="~/link.aspx?_id=0FEC2DA57092453EAD73F6DE0B4CF11F&_z=z">Strålesyge</a></li> </ul> <h4>Information fra Kræften Bekæmpelse</h4> <ul> <li><a href="http://www.cancer.dk/">Kræftens Bekæmpelse</a></li> </ul> <h4>Lindrende behandling ved fremskreden kræftsygdom</h4> <ul> <li><a href="~/link.aspx?_id=DF00C370DFDE4F2390F10019CDDD3195&_z=z">Angst</a></li> <li><a href="~/link.aspx?_id=5A8AD6070C994010BE0FC18E68A45E9A&_z=z">Kvalme og opkast</a></li> <li><a href="~/link.aspx?_id=47A58FFAC9AC4503A4DEB9B826162E3E&_z=z">Forstoppelse</a></li> <li><a href="~/link.aspx?_id=32029ED6BC4C4D66AE32A03E69B02764&_z=z">Mundtørhed</a></li> <li><a href="~/link.aspx?_id=71006191216D4F91B7E0441CF1297B68&_z=z">Vejrtrækningsbesvær</a></li> <li><a href="~/link.aspx?_id=A8465A9A8EFC44FF933BBAB1B8922D80&_z=z">Alvorlig afmagring</a></li> <li><a href="~/link.aspx?_id=5B6D4EF5C7F5402A87C35C95E633B262&_z=z">Depression</a></li> <li><a href="~/link.aspx?_id=920A105AD9CD437B86A9783DCE075286&_z=z">Delirium</a></li> </ul> <h3>Patientorganisationer</h3> <ul> <li><a rel="noopener noreferrer" href="https://www.cancer.dk/" target="_blank">Kræften Bekæmpelse</a></li> </ul> <h2>Link til vejledninger</h2> <ul> <li><a href="http://www.lungecancer.dk">Dansk Lunge Cancer Gruppe 2020. Visitation, Diagnostik og Stadieinddeling</a></li> <li><a href="https://www.lungemedicin.dk/fagligt/64-mediastinal-udredning-ved-lungecancer.html">Lungecancer - Mediastinal udredning. Retningslinje fra Dansk Lungemedicinsk Selskab</a> </li> <li><a href="https://www.lungemedicin.dk/fagligt/78-lungecancer-udredning-ved-mistanke-om-malign-lidelse-i-thorax.html">Lungecancer - udredning ved mistanke til malign lidelse i thorax. Dansk Lungemedicinsk Selskab</a></li> <a href="https://www.sst.dk/da/udgivelser/2018/pakkeforloeb-for-lungekraeft">National pakkeforløb</a> <li>Forløbsbeskrivelser og pakkeforløb [ICPC] </li> <li>DSAM klinisk vejledning - <a href="http://vejledninger.dsam.dk/cancer/">Kræftopfølgning i almen praksis</a></li> </ul> <h2>Illustrationer</h2> <h3>Billeder</h3> <ul> <li> <a href="~/link.aspx?_id=602C411FD1A148EB9979F2F30FF02D92&_z=z">Småcellet anaplastisk karcinom, før behandling, rtg.</a> </li> <li> <a href="~/link.aspx?_id=866BDD9D17E94C5E9381FEB800913236&_z=z">Småcellet anaplastisk karcinom, efter behandling, rtg.</a> </li> <li> <a href="~/link.aspx?_id=F86674F8E7C64B539676956DB69E821B&_z=z">Lungecancer, CT</a> </li> <li> <a href="~/link.aspx?_id=8008C7D3BF804022B26564A70A91479C&_z=z">Lungecancer, rtg.</a> </li> </ul> <h3>Tegninger</h3> <ul> <li> <a href="~/link.aspx?_id=8FF721DA6EA043308D32FA73A998349B&_z=z">Illustration af normale lunger og bronkier</a></li> </ul> <div id="teamshare-chrome-client-app-extension"> </div>]]></HtmlField> <HtmlField Name="PageReferences"><![CDATA[<div> </div>]]></HtmlField> <HtmlField Name="Resume"><![CDATA[<h2>Resumé</h2> <h3>Diagnose</h3> <ul> <li>Mistænkes hos rygere med nye luftvejssymptomer ud over seks uger, inklusiv forværring af kendt tobakshoste</li> <li>Malignitetssuspekt infiltrat på røntgen af thorax skal føre til henvisning til pakkeforløb for lungekræft</li> <li>Ved mistanke til trods for et normalt røntgenbillede (fx hæmoptyse), bør patienten henvises til pakkeforløb for lungekræft med CT-skanning med kontrast af thorax og øvre abdomen </li> <li>Endelig diagnose kræver biopsitagning</li> </ul> <h3>Behandling</h3> <ul> <li>Afhænger af histologi, stadium, molekylær subklassifikation og ko-morbiditet</li> <li>Kan omfatte kirurgi, kemoterapi, immunterapi og stråler</li> <li>Kan være med kurativt eller med palliativt sigte</li> </ul> <h3>Henvisning</h3> <ul> <li>Studier har vist betydelig diagnostisk 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