tyfus-vaccine (LH Indholdsside)

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      <HtmlField Name="PageContent"><![CDATA[<h2>Indikationer</h2>
<ul>
    <li>Rejser til omr&aring;der hvor tyfus er endemisk<a href=" " data-type="journal-reference" data-value="Wain J, Hendriksen R, Mikoleit M, Keddy KH, Ochiai RL, Typhoid fever. Lancet 2015;385: 1136-1145" data-value-piped="Wain J, Hendriksen R, Mikoleit M, Keddy KH, Ochiai RL|Typhoid fever|Lancet|2015|385|1136-1145" data-url="reference-link" title="Wain J, Hendriksen R, Mikoleit M, Keddy KH, Ochiai RL, Typhoid fever. Lancet 2015;385: 1136-1145">1</a><sup>,</sup><a href=" " data-type="journal-reference" data-value="Dave J, Sefton A, Enteric fever and its impact on returning travellers. International health 2015;7: 163-168" data-value-piped="Dave J, Sefton A|Enteric fever and its impact on returning travellers|International health|2015|7|163-168" data-url="reference-link" title="Dave J, Sefton A, Enteric fever and its impact on returning travellers. International health 2015;7: 163-168">2</a>
    <ul>
        <li>Smittefaren stiger med varigheden af opholdet </li>
        <li>Den st&oslash;rste smittefare ses hos rejsende, der bes&oslash;ger familie eller venner</li>
    </ul>
    </li>
</ul>
<h3>Kontraindikationer</h3>
<ul>
    <li>Alvorlig reaktion p&aring; tidligere dosis af samme vaccine </li>
    <li>Alder under 2 &aring;r p&aring; grund af d&aring;rlig effekt </li>
    <li>Skal ikke gives ved akut infektion med feber over 38&deg;C </li>
    <li>For den perorale vaccine g&aelig;lder desuden:
    <ul>
        <li>Akut tarmsygdom </li>
        <li>Behandling med antibiotika, fordi vaccinen kan inaktiveres i tarmen </li>
        <li>En r&aelig;kke malariapr&aelig;parater (bl.a. chloroquin) m&aring; tidligst tages 3 dage efter sidste tyfusvaccinekapsel</li>
        <li>Alder under 5 &aring;r p&aring; grund af manglende information om effekt og sikkerhed</li>
        <li>Personer med nedsat immunforsvar</li>
        <li>Kendt allergi mod indholdsstoffer i vaccinen</li>
        <li>B&oslash;r kun p&aring; tvingende indikation gives til b&oslash;rn, da den indeholder bl&oslash;dg&oslash;rende stoffer (dibutylphalater) over det tilladte niveau for b&oslash;rn&nbsp;</li>
    </ul>
    </li>
</ul>
<h2>Vacciner</h2>
<ul>
    <li>[DliActiveSubstance;6339;En peroral vaccine]&nbsp;lavet af levende, sv&aelig;kket <em>Salmonella typhi</em> </li>
    <li>[DliActiveSubstance;8905;Parenteral vaccine&nbsp;]lavet af kapselpolysakkarid fra <em>Salmonella typhi</em></li>
    <li>Der findes ogs&aring; en parenteral vaccine&nbsp;til samtidig vaccination mod b&aring;de&nbsp;<em>Salmonella typhi&nbsp;</em>og <em>Hepatitis A. </em>Den er aktuelt ikke markedsf&oslash;rt i Danmark</li>
</ul>
<h2>Dosering</h2>
<ul>
    <li>[DliActiveSubstance;6339;Peroral vaccine]<br>
    <ul>
        <li>Voksne og b&oslash;rn over 5 &aring;r: dag 1, 3 og 5 tages 1 kapsel 1 time f&oslash;r et m&aring;ltid </li>
        <li>Revaccination: samme dosering med 1 kapsel dag 1, 3 og 5</li>
        <li>Ved rejse til endemisk omr&aring;de anbefales revaccination efter 1 &aring;r</li>
        <li>For personer bosiddende i endemisk omr&aring;de anbefales revaccination hvert 3. &aring;r&nbsp;</li>
    </ul>
    </li>
    <li>[DliActiveSubstance;8905;Parenteral vaccine]<br>
    <ul>
        <li>Voksne og b&oslash;rn over 2 &aring;r: 1 dosis &agrave; 0,5 ml s.c. eller i.m. </li>
        <li>Revaccination: 1 dosis efter 3 &aring;r</li>
    </ul>
    </li>
</ul>
<h2>Information</h2>
<ul>
    <li>B&aring;de peroral og parenteral vaccine giver op mod 70 % beskyttelse<a href=" " data-type="journal-reference" data-value="Mahon BE, Newton AE, Mintz ED, Effectiveness of typhoid vaccination in US travelers. Vaccine 2014;32: 3577-3579" data-value-piped="Mahon BE, Newton AE, Mintz ED|Effectiveness of typhoid vaccination in US travelers|Vaccine|2014|32|3577-3579|24837780 " data-url="reference-link" data-pubmedid="24837780 " title="Mahon BE, Newton AE, Mintz ED, Effectiveness of typhoid vaccination in US travelers. Vaccine 2014;32: 3577-3579">3</a><sup>,</sup><a href=" " data-type="journal-reference" data-value="Milligan R, Paul M, Richardson M, Neuberger A., Vaccines for preventing typhoid fever. Cochrane Database Syst Rev. 2018;5: " data-value-piped="Milligan R, Paul M, Richardson M, Neuberger A.|Vaccines for preventing typhoid fever|Cochrane Database Syst Rev.|2018|5||29851031" data-url="reference-link" data-pubmedid="29851031" title="Milligan R, Paul M, Richardson M, Neuberger A., Vaccines for preventing typhoid fever. Cochrane Database Syst Rev. 2018;5: ">4</a></li>
    <li>Beskyttelse opn&aring;s efter 2 uger og varer i mindst 1 &aring;r for den perorale og mindst 3 &aring;r for den parenterale vaccine</li>
    <li>Den parenterale vaccine beskytter ikke mod paratyfus. Den perorale vaccine giver m&aring;ske nogen beskyttelse mod paratyfus<a href=" " data-type="journal-reference" data-value="Jackson BR, Iqbal S, Mahon B, Centers for Disease Control and Prevention (CDC)., Updated recommendations for the use of typhoid vaccine--Advisory Committee on Immunization Practices, United States, 2015. MMWR Morb Mortal Wkly Rep 2015;64: 305-8" data-value-piped="Jackson BR, Iqbal S, Mahon B, Centers for Disease Control and Prevention (CDC).|Updated recommendations for the use of typhoid vaccine--Advisory Committee on Immunization Practices, United States, 2015.|MMWR Morb Mortal Wkly Rep|2015|64|305-8|25811680" data-url="reference-link" data-pubmedid="25811680" title="Jackson BR, Iqbal S, Mahon B, Centers for Disease Control and Prevention (CDC)., Updated recommendations for the use of typhoid vaccine--Advisory Committee on Immunization Practices, United States, 2015. MMWR Morb Mortal Wkly Rep 2015;64: 305-8">5</a>&nbsp;</li>
</ul>
<h2>Information om tilstanden</h2>
<ul>
    <li>
    <a href="~/link.aspx?_id=47CDC70A044345D3823E2A8B9BD42AB3&amp;_z=z">Tyfus</a> - for sundhedsfaglige </li>
    <li>
    <a href="~/link.aspx?_id=9E555C1B6A644B20BC6E84026F9708DE&amp;_z=z">Tyfus</a> - patientinformation</li>
</ul>
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