elastase-1 (LH Indholdsside)

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      <HtmlField Name="PageContent"><![CDATA[<h2>Definition</h2>
<ul>
    <li>Koncentrationen af pancreasenzymet elastase 1 i f&aelig;ces, m&aring;lt i mikrogram per gram (&mu;g/g)</li>
    <li>Elastase-1 produceres i pancreas, secerneres til tarmlumen og passerer uomdannet igennem tarmkanalen</li>
    <li>Niveauet er et godt udtryk for pancreas' eksokrine funktion, da der er en direkte sammenh&aelig;ng mellem den duodenale sekretion fra pancreas og koncentrationen af elastase-1 i aff&oslash;ringen</li>
</ul>
<h2>Synonymer</h2>
<ul>
    <li>Pankreas-elastase 1, f&aelig;ces-elastase, human pancreas elastase</li>
</ul>
<h2>Indikationer</h2>
<ul>
    <li>Mistanke om eksokrin pancreasinsufficiens, fx hos patienter med<a href="EditorPage.aspx?da=core&amp;id=%7BD1AF94D8-C3A7-4D4E-8BB6-FE2C22130DA6%7D&amp;ed=FIELD731018759&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H731018823&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Lewis DM, A Systematic Review of Exocrine Pancreatic Insufficiency Prevalence and Treatment in Type 1 and Type 2 Diabetes. Diabetes Technol Ther 2023;25: 659-672" data-value-piped="Lewis DM|A Systematic Review of Exocrine Pancreatic Insufficiency Prevalence and Treatment in Type 1 and Type 2 Diabetes.|Diabetes Technol Ther|2023|25|659-672|37440180" data-url="reference-link" data-pubmedid="37440180" title="Lewis DM, A Systematic Review of Exocrine Pancreatic Insufficiency Prevalence and Treatment in Type 1 and Type 2 Diabetes. Diabetes Technol Ther 2023;25: 659-672"><sup>1</sup></a><sup>,</sup><a href="https://dsgh.dk/wp-content/uploads/2022/06/kroniskpankreatitis.pdf" data-type="other-reference" data-value="Diagnostik og behanding af kronisk pancreatit" data-url="https://dsgh.dk/wp-content/uploads/2022/06/kroniskpankreatitis.pdf" title="Diagnostik og behanding af kronisk pancreatit"><sup>2</sup></a><sup>,</sup><a href="EditorPage.aspx?da=core&amp;id=%7BD1AF94D8-C3A7-4D4E-8BB6-FE2C22130DA6%7D&amp;ed=FIELD27581471714&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H27581471797&amp;us=sitecore%5Canvi&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Forsmark CE, Diagnosis and Management of Exocrine Pancreatic Insufficiency. Curr Treat Options Gastroenterol 2018;16: 306-315" data-value-piped="Forsmark CE|Diagnosis and Management of Exocrine Pancreatic Insufficiency.|Curr Treat Options Gastroenterol|2018|16|306-315|30027527" data-url="reference-link" data-pubmedid="30027527" title="Forsmark CE, Diagnosis and Management of Exocrine Pancreatic Insufficiency. Curr Treat Options Gastroenterol 2018;16: 306-315"><sup>3</sup></a><sup>,</sup><a href="EditorPage.aspx?da=core&amp;id=%7BD1AF94D8-C3A7-4D4E-8BB6-FE2C22130DA6%7D&amp;ed=FIELD27581471714&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H27581471797&amp;us=sitecore%5Canvi&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Vanga RR, Tansel A, Sidiq S, El-Serag HB, Othman MO, Diagnostic Performance of Measurement of Fecal Elastase-1 in Detection of Exocrine Pancreatic Insufficiency: Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol 2018;16: 1220-1228.e4" data-value-piped="Vanga RR, Tansel A, Sidiq S, El-Serag HB, Othman MO|Diagnostic Performance of Measurement of Fecal Elastase-1 in Detection of Exocrine Pancreatic Insufficiency: Systematic Review and Meta-analysis.|Clin Gastroenterol Hepatol|2018|16|1220-1228.e4|29374614" data-url="reference-link" data-pubmedid="29374614" title="Vanga RR, Tansel A, Sidiq S, El-Serag HB, Othman MO, Diagnostic Performance of Measurement of Fecal Elastase-1 in Detection of Exocrine Pancreatic Insufficiency: Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol 2018;16: 1220-1228.e4"><sup>4</sup></a>
    <ul>
        <li>Ford&oslash;jelsesvanskeligheder</li>
        <li>Ern&aelig;ringsproblemer (uforklarligt v&aelig;gttab, mangelsygdomme)</li>
        <li>Kronisk diarr&eacute; eller fedtdiarr&eacute;</li>
        <li>Uforklarlige mavesmerter</li>
    </ul>
    </li>
    <li>Vurdering af pancreasfunktionen hos patienter med&nbsp;<a href="~/link.aspx?_id=F61E1F9A4D594FCF8DDAC06DEFC9A759&amp;_z=z">kronisk pancreatit</a>,&nbsp;<a href="~/link.aspx?_id=4AF69BE2DC654560A3C10662691E6436&amp;_z=z">cystisk fibrose</a>, cholelithiasis, diabetes eller andre tilstande</li>
    <li>Opf&oslash;lgning p&aring; behandling med pancreasenzymer<a href=" " data-type="journal-reference" data-value="Huang W, de la Iglesia-García D, Baston-Rey I, Calviño-Suarez C, Lariño-Noia J, Iglesias-Garcia J, Shi N, Zhang X, Cai W, Deng L, Moore D, Singh VK, Xia Q, Windsor JA, Domínguez-Muñoz JE, Sutton R, Exocrine Pancreatic Insufficiency Following Acute Pancreatitis: Systematic Review and Meta-Analysis. Dig Dis Sci 2019;64: 1985-2005" data-value-piped="Huang W, de la Iglesia-García D, Baston-Rey I, Calviño-Suarez C, Lariño-Noia J, Iglesias-Garcia J, Shi N, Zhang X, Cai W, Deng L, Moore D, Singh VK, Xia Q, Windsor JA, Domínguez-Muñoz JE, Sutton R|Exocrine Pancreatic Insufficiency Following Acute Pancreatitis: Systematic Review and Meta-Analysis.|Dig Dis Sci|2019|64|1985-2005|31161524" data-url="reference-link" data-pubmedid="31161524" title="Huang W, de la Iglesia-García D, Baston-Rey I, Calviño-Suarez C, Lariño-Noia J, Iglesias-Garcia J, Shi N, Zhang X, Cai W, Deng L, Moore D, Singh VK, Xia Q, Windsor JA, Domínguez-Muñoz JE, Sutton R, Exocrine Pancreatic Insufficiency Following Acute Pancreatitis: Systematic Review and Meta-Analysis. Dig Dis Sci 2019;64: 1985-2005"><sup>5</sup></a></li>
</ul>
<h2>Fortolkninger<a href=" " data-type="journal-reference" data-value="Khan A, Vege SS, Dudeja V, Chari ST, Staging exocrine pancreatic dysfunction. Pancreatology 2022;22: 168-172" data-value-piped="Khan A, Vege SS, Dudeja V, Chari ST|Staging exocrine pancreatic dysfunction.|Pancreatology|2022|22|168-172|34916141" data-url="reference-link" data-pubmedid="34916141" title="Khan A, Vege SS, Dudeja V, Chari ST, Staging exocrine pancreatic dysfunction. Pancreatology 2022;22: 168-172"><sup>6</sup></a></h2>
<ul>
    <li>Lav koncentration af Elastase-1 skyldes enten blokade af ductus pancreaticus eller skade/destruktion af pancreasceller. Som oftest som f&oslash;lge af&nbsp;<a href="~/link.aspx?_id=F61E1F9A4D594FCF8DDAC06DEFC9A759&amp;_z=z">kronisk pancreatit</a>&nbsp;eller pancreas cancer. Hos b&oslash;rn ses det oftest som f&oslash;lge af&nbsp;<a href="~/link.aspx?_id=4AF69BE2DC654560A3C10662691E6436&amp;_z=z">cystisk fibrose</a>&nbsp;eller <a href="http://www.sundhed.dk/sundhedsfaglig/laegehaandbogen/sjaeldne-sygdomme/sjaeldne-sygdomme/shwachman-diamonds-syndrom/">Shwachman-Diamond syndrom</a></li>
    <li>Under 100 &mu;g/g: Sv&aelig;r pancreasinsufficiens</li>
    <li>100-200 &mu;g/g: Let til moderat pancreasinsufficiens</li>
</ul>
<h2>Fejlkilder (og kilder til normal variation)</h2>
<ul>
    <li>Ved vandige diarr&eacute;er kan koncentrationen blive falsk for lav. Unders&oslash;gelsen b&oslash;r da gentages</li>
    <li>Enzym substitutionsterapi:&nbsp;Der er ikke fundet nogen krydsreaktion mellem antistoffer brugt til analysen og f&oslash;lgende substitutionspr&aelig;parater: Pangrol 25.000, Panzytrat 40.000, Pankreatin 36.000, Kreon 40.000 eller Cotazym</li>
</ul>
<h2>Fysiologi og biokemi</h2>
<ul>
    <li>Elastase-1 er et enzym produceret i eksokrint v&aelig;v i pancreas og er mark&oslash;r for pancreas' eksokrine funktion</li>
    <li>Det secerneres til tarmlumen og passerer uomdannet igennem tarmkanalen</li>
    <li>Da der er en direkte sammenh&aelig;ng mellem den duodenale sekretion fra pancreas og koncentrationen af elastase-1 i aff&oslash;ringen, er niveauet et godt udtryk for pancreas' eksokrine funktion. Der sker en opkoncentrering af pancreaselastase ved passagen gennem tarmen og koncentrationen i f&aelig;ces er derfor meget st&oslash;rre end i pancreas</li>
</ul>
<h2>Pr&oslash;vetagning</h2>
<ul>
    <li>Der skal anvendes 1-5 gram f&aelig;ces (svarende til en &aelig;rt) fra et tilf&aelig;ldigt omr&aring;de af aff&oslash;ringen</li>
    <li>Pr&oslash;ven opsamles i et s&aelig;rlig pr&oslash;ver&oslash;r og sendes til laboratoriet med almindelig post</li>
    <li>Pr&oslash;ven er holdbar i 5 d&oslash;gn ved stuetemperatur</li>
</ul>
<h2>Referenceintervaller</h2>
<ul>
    <li>Over 200 &micro;g/g</li>
</ul>
<h2>NPU-koder og -navne</h2>
<ul>
    <li>
    NPU28718</li>
</ul>
<h3>Navne</h3>
<ul>
    <li><strong>Kort helterm</strong>
    <ul>
        <li>F&mdash;Pancreaselastase I; massefr. = ? &times; 10-6 &micro;g/g</li>
    </ul>
    </li>
    <li><strong>Brugsnavn</strong>
    <ul>
        <li>Pancreaselastase I;F</li>
    </ul>
    </li>
</ul>]]></HtmlField>
      <HtmlField Name="Resume"><![CDATA[<h2>Resum&eacute;</h2>
<ul>
    <li>Koncentrationen af elastase-1 i aff&oslash;ringen er et udtryk for pancreas' eksokrine funktion</li>
    <li>Koncentrationer mindre end 100 &mu;g/g indicerer sv&aelig;r pancreasinsufficiens og ses oftest som f&oslash;lge af kronisk pancreatitis hos voksne eller cystisk fibrose hos b&oslash;rn</li>
    <li>Hvis pr&oslash;ven er meget vandig bliver resultatet falsk for lavt</li>
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