Erytrocytter-vol-fr-EVF (LH Indholdsside)

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      <HtmlField Name="PageContent"><![CDATA[<h2>Definition</h2>
<ul>
    <li>Den fraktion af blodvolumenet, der udg&oslash;res af erytrocytterne. V&aelig;rdien er s&aring;ledes bestemt af antallet af erytrocytter og deres st&oslash;rrelse</li>
</ul>
<h2>Synonymer</h2>
<ul>
    <li>H&aelig;matokrit; Hematocrit (engelsk); Hct; HCT; Erytrocytvolumenfraktion; EVF; Packed Cell Volume (PCV);&nbsp;</li>
</ul>
<h2>Indikationer</h2>
<ul>
    <li>EVF er meget h&oslash;jt korreleret til b&aring;de&nbsp;<a href="~/link.aspx?_id=ABAFD55610444920B72E5238AE982D06&amp;_z=z">erytrocytantallet</a>, middelcellevolumen (MCV)&nbsp;og&nbsp;<a href="~/link.aspx?_id=1D0865567D7A4C5390DD04F060A183C4&amp;_z=z">h&aelig;moglobin</a>, og vil stort set altid blive rekvireret og fortolket sammen med disse variable</li>
    <li>EVF indg&aring;r i behandlingsm&aring;let for&nbsp;<a href="~/link.aspx?_id=2E232CB2AFD34E3B9A8A852F26E4B42B&amp;_z=z">polycyt&aelig;mia vera</a>: skal v&aelig;re under 0,45 hos m&aelig;nd og under 0,42 hos kvinder</li>
    <li>EVF anvendes i forskellige algoritmer til p&aring;visning af bloddoping eller EPO-misbrug blandt sportsfolk<a href=" " data-type="journal-reference" data-value="Sottas PE, Robinson N, Saugy M, The athlete's biological passport and indirect markers of blood doping. Handb Exp Pharmacol 2010;: 305-26" data-value-piped="Sottas PE, Robinson N, Saugy M|The athlete's biological passport and indirect markers of blood doping.|Handb Exp Pharmacol|2010||305-26|20020371" data-url="reference-link" data-pubmedid="20020371" title="Sottas PE, Robinson N, Saugy M, The athlete's biological passport and indirect markers of blood doping. Handb Exp Pharmacol 2010;: 305-26"><sup>1</sup></a></li>
</ul>
<h2>Fortolkning<a href="EditorPage.aspx?da=core&amp;id=%7B0DEF2A9F-99A5-49DB-8A02-81E71630BDEA%7D&amp;ed=FIELD27581467486&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H27581467567&amp;us=sitecore%5Canvi&amp;mo&amp;pe=0&amp;fbd=1#" data-type="book-reference" data-value="Thomas L (red). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998" data-value-piped="Thomas L (red)|Clinical laboratory diagnostics. Use and assessment of clinical laboratory results|Frankfurt am Main|TH-Books Verlagsgesellschaft mbH|1998" data-url="reference-link" title="Thomas L (red). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998"><sup>2</sup></a></h2>
<ul>
    <li>EVF b&oslash;r altid fortolkes sammen med&nbsp;<a href="~/link.aspx?_id=1D0865567D7A4C5390DD04F060A183C4&amp;_z=z">h&aelig;moglobin</a>&nbsp;og resultaterne af en&nbsp;<a href="~/link.aspx?_id=E8331EE44129490180542CEF5EA275A5&amp;_z=z">erytrocytunders&oslash;gelse</a></li>
</ul>
<h3>Forh&oslash;jede v&aelig;rdier ses ved:</h3>
<ul>
    <li>Et &oslash;get antal erytrocytter, dvs.&nbsp;<a href="~/link.aspx?_id=1141F3CB5E154AB58E0ABD548B280EF7&amp;_z=z">polycyt&aelig;mi</a><a href=" " data-type="journal-reference" data-value="Pillai AA, Fazal S, Babiker HM, Polycythemia. StatPearls 2021;: " data-value-piped="Pillai AA, Fazal S, Babiker HM|Polycythemia|StatPearls|2021|||30252337" data-url="reference-link" data-pubmedid="30252337" title="Pillai AA, Fazal S, Babiker HM, Polycythemia. StatPearls 2021;: "><sup>3</sup></a>. Polycyt&aelig;mi kan v&aelig;re prim&aelig;r (Polycyt&aelig;mia Vera) eller hyppigere sekund&aelig;r, hvilket kan skyldes eksempelvis lunge og hjertesygdomme, rygning eller tumorer</li>
    <li>Et reduceret plasmavolumen, dvs.&nbsp;<a href="~/link.aspx?_id=C3F7AFA937C947C7BF0F6457752CE43F&amp;_z=z">dehydrering</a></li>
    <li>Ved h&aelig;matokrit &gt; ~0,60 stiger risikoen for trombose betydeligt</li>
</ul>
<h3>Lave v&aelig;rdier ses ved:</h3>
<ul>
    <li>Et reduceret antal erytrocytter, dvs.&nbsp;<a href="~/link.aspx?_id=5FCAB0AC3CA7470BAB5F482DBFE93E9C&amp;_z=z">an&aelig;mi</a></li>
    <li>Et &oslash;get plasmavolumen, dvs. overhydrering</li>
</ul>
<h3>Normale v&aelig;rdier!</h3>
<ul>
    <li>V&aelig;r opm&aelig;rksom p&aring;, at der kan g&aring; helt op til 12 timer, f&oslash;r EVF (og h&aelig;moglobin og erytrocyttallet) falder efter en st&oslash;rre, akut bl&oslash;dning<a href="EditorPage.aspx?da=core&amp;id=%7B0DEF2A9F-99A5-49DB-8A02-81E71630BDEA%7D&amp;ed=FIELD27581467486&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H27581467567&amp;us=sitecore%5Canvi&amp;mo&amp;pe=0&amp;fbd=1#" data-type="book-reference" data-value="Thomas L (red). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998" data-value-piped="Thomas L (red)|Clinical laboratory diagnostics. Use and assessment of clinical laboratory results|Frankfurt am Main|TH-Books Verlagsgesellschaft mbH|1998" data-url="reference-link" title="Thomas L (red). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998"><sup>2</sup></a></li>
    <li>Dehydrering kan maskere en (let) an&aelig;mi, og overhydrering kan maskere polycyt&aelig;mi</li>
</ul>
<h2>Fejlkilder (og kilder til normal variation)</h2>
<ul>
    <li>Forhold, der giver fejl i m&aring;linger af erytrocytter og/eller MCV, medf&oslash;rer ogs&aring; fejl i den beregnede EVF. Se&nbsp;<a href="~/link.aspx?_id=E8331EE44129490180542CEF5EA275A5&amp;_z=z">erytrocytunders&oslash;gelse</a></li>
    <li>MCV stiger med tiden, fordi cellerne svulmer op i pr&oslash;ver&oslash;ret. Der kan derfor f&aring;s falsk forh&oslash;jede MCV-v&aelig;rdier og dermed ogs&aring; falsk forh&oslash;jede EVF-v&aelig;rdier, n&aring;r der m&aring;les p&aring; indsendt pr&oslash;vemateriale. Stigningen sker i l&oslash;bet af f&oslash;rste d&oslash;gn efter pr&oslash;vetagning, og problemet tiltager med tiden</li>
    <li>Lav P-Natrium-ion (&lt; 130 mmol/l); stofk. hos en patient kan medf&oslash;re m&aring;leteknisk falsk lav v&aelig;rdi af EVF, da erytrocytterne vil skrumpe som f&oslash;lge af den fortynding der sker i selve analyseprocessen. Omvendt vil et h&oslash;jt natrium-niveau i plasma (&gt; 160 mmol/L) foranledige et falsk for h&oslash;jt MCV og dermed ogs&aring; EVF&nbsp;<a href="https://dbio.dk/files/media/import/Blad%2520nr.%252010%2520-%25202015%2520side%252020-23.pdf" data-type="other-reference" data-value="Fagbladet Danske Bioanalytikere, Blad nr. 10 - 2015 side 20-23, Beregning og måling af, hvordan erytrocyt-størrelse påvirkes af P-Natrium" data-url="https://dbio.dk/files/media/import/Blad%2520nr.%252010%2520-%25202015%2520side%252020-23.pdf" title="Fagbladet Danske Bioanalytikere, Blad nr. 10 - 2015 side 20-23, Beregning og måling af, hvordan erytrocyt-størrelse påvirkes af P-Natrium"><sup>4</sup></a></li>
    <li>Ved udtalt reticulocytose eller leukocytose kan der f&aring;s falsk forh&oslash;jede v&aelig;rdier, fordi de h&oslash;je volumina af disse celletyper p&aring;virker beregningen af EVF<a href="EditorPage.aspx?da=core&amp;id=%7B0DEF2A9F-99A5-49DB-8A02-81E71630BDEA%7D&amp;ed=FIELD27581467486&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H27581467567&amp;us=sitecore%5Canvi&amp;mo&amp;pe=0&amp;fbd=1#" data-type="book-reference" data-value="Thomas L (red). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998" data-value-piped="Thomas L (red)|Clinical laboratory diagnostics. Use and assessment of clinical laboratory results|Frankfurt am Main|TH-Books Verlagsgesellschaft mbH|1998" data-url="reference-link" title="Thomas L (red). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998"><sup>2</sup></a></li>
    <li>Se ogs&aring;&nbsp;<a href="~/link.aspx?_id=1D0865567D7A4C5390DD04F060A183C4&amp;_z=z">h&aelig;moglobin</a></li>
</ul>
<h2>Biokemisk baggrund</h2>
<ul>
    <li>Erytrocytvolumenfraktionen (EVF) er et samlet m&aring;l bestemt af erytrocytternes antal og st&oslash;rrelse</li>
    <li>EVF m&aring;les sj&aelig;ldent direkte, men beregnes som antal erytrocytter per liter blod multipliceret med deres middelcellevolumen (MCV)</li>
</ul>
<h2>Pr&oslash;vetagning</h2>
<ul>
    <li>EDTA-stabiliseret veneblod</li>
    <li>Hvis EVF skal m&aring;les direkte med den s&aring;kaldte mikroh&aelig;matokrit centrifugeringsmetode, skal det ske inden for 6 timer efter pr&oslash;vetagningen<a href="EditorPage.aspx?da=core&amp;id=%7B0DEF2A9F-99A5-49DB-8A02-81E71630BDEA%7D&amp;ed=FIELD27581467486&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H27581467567&amp;us=sitecore%5Canvi&amp;mo&amp;pe=0&amp;fbd=1#" data-type="book-reference" data-value="Thomas L (red). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998" data-value-piped="Thomas L (red)|Clinical laboratory diagnostics. Use and assessment of clinical laboratory results|Frankfurt am Main|TH-Books Verlagsgesellschaft mbH|1998" data-url="reference-link" title="Thomas L (red). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998"><sup>2</sup></a></li>
</ul>
<h2>Referenceintervaller</h2>
<ul>
    <li>Der kan v&aelig;re (mindre) forskelle i de angivne intervaller fra laboratorium til laboratorium, men de fleste anvender nedenst&aring;ende intervaller. </li>
    <li>Voksne &ge;18 &aring;r
    <ul>
        <li>M&aelig;nd: 0,40 - 0,50</li>
        <li>Kvinder: 0,35 - 0,46</li>
    </ul>
    </li>
    <li>Gravide: 0,31 - 0,42</li>
    <li>B&oslash;rn
    <ul>
        <li>Navlesnorsblod: 0,48 - 0,56</li>
        <li>0 - 2 uger: 0,33 - 0,59</li>
        <li>2 - 4 uger: 0,27 - 0,50</li>
        <li>4 - 8 uger: 0,25 - 0,42</li>
        <li>8 uger&nbsp;- 12 &aring;r: 0,28 - 0,42</li>
        <li>12 - 18 &aring;r: 0,32 - 0,47</li>
    </ul>
    </li>
</ul>
<h2>Patientinformation</h2>
<ul>
    <li><a href="~/link.aspx?_id=80AB5E14686F4A76BD9638DE8A81FD6D&amp;_z=z">B-erytrocytter (r&oslash;de blodlegemer)</a></li>
</ul>
<h2>NPU-koder og -navne</h2>
<ul>
    <li>NPU01961</li>
</ul>
<h3>Navne</h3>
<ul>
    <li><strong>Langt navn</strong>
    <ul>
        <li>B&mdash;Erythrocytter; vol.fr. = ?&nbsp;</li>
    </ul>
    </li>
    <li><strong>Kort navn</strong>
    <ul>
        <li>Erytrocytter, vol.fr.;B</li>
    </ul>
    </li>
</ul>]]></HtmlField>
      <HtmlField Name="Resume"><![CDATA[<h2>Resum&eacute;</h2>
<ul>
    <li>Erytrocytvolumenfraktionen (EVF) er et samlet m&aring;l for erytrocytternes antal og st&oslash;rrelse. V&aelig;rdien afspejler ogs&aring; h&aelig;moglobinkoncentrationen</li>
    <li>Er s&aelig;rligt indiceret ved mistanke om&nbsp;polycyt&aelig;mi&nbsp;herunder ogs&aring;&nbsp;<a href="~/link.aspx?_id=2E232CB2AFD34E3B9A8A852F26E4B42B&amp;_z=z">polycythaemia-vera</a>,&nbsp;hvor EVF&nbsp;indg&aring;r som et diagnostisk kriterium og behandllingsm&aring;l</li>
    <li>B&oslash;r ellers altid vurderes sammen med &oslash;vrige&nbsp;<a href="https://www.sundhed.dk/sundhedsfaglig/laegehaandbogen/undersoegelser-og-proever/klinisk-biokemi/blodproever/erytrocytundersoegelse/">erytrocyt-parametre</a>&nbsp;og med diverse variationskilder in mente </li>
</ul>]]></HtmlField>
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