asat (LH Indholdsside)

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      <HtmlField Name="PageContent"><![CDATA[<h2>Resum&eacute;</h2>
<ul>
    <li>Uspecifik mark&oslash;r for skade p&aring;&nbsp;flere typer v&aelig;v</li>
    <li>Analysen er yderst sj&aelig;ldent indiceret og udf&oslash;res derfor ikke p&aring; ret mange laboratorier</li>
    <li>Indg&aring;r i algoritme til estimering af leverfibrose&nbsp;<a href="~/link.aspx?_id=75EB2C747EE04008BCAE16072A7C2C82&amp;_z=z">FIB-4</a>&nbsp;(Fibrosis-4)</li>
    <li>Den udf&oslash;res ellers mest i forbindelse med forskningsprojekter&nbsp;</li>
</ul>
<h2>Definition</h2>
<ul>
    <li>Koncentrationen af enzymet <strong>as</strong>partat-<strong>a</strong>mino<strong>t</strong>ransferase (ASAT i plasma, m&aring;lt som enheder (units) af dets katalytiske aktivitet per liter (U/L))</li>
</ul>
<h2>Synonymer</h2>
<ul>
    <li>P- eller S-ASAT; aspartattransaminase (AST); glutamyl-oxaloacetat transaminase (GOT)</li>
</ul>
<h2>Fortolkninger<a href="%20" title="Thomas L (ed). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998" data-url="reference-link" data-value="Thomas L (ed). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998" data-type="book-reference" data-value-piped="Thomas L (ed)|Clinical laboratory diagnostics. Use and assessment of clinical laboratory results|Frankfurt am Main|TH-Books Verlagsgesellschaft mbH|1998">1</a><sup>,</sup><a href="EditorPage.aspx?da=core&amp;id=%7B1EC226C2-8A70-4C08-985C-187EE58092BF%7D&amp;ed=FIELD17668611731&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H17668611880&amp;us=sitecore%5Canvi&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Green RM, Flamm S, AGA technical review on the evaluation of liver chemistry tests.. Gastroenterology 2002;123: 1367-84" data-value-piped="Green RM, Flamm S|AGA technical review on the evaluation of liver chemistry tests.|Gastroenterology|2002|123|1367-84|12360498" data-url="reference-link" data-pubmedid="12360498" title="Green RM, Flamm S, AGA technical review on the evaluation of liver chemistry tests.. Gastroenterology 2002;123: 1367-84">2</a><sup>,</sup><a href="EditorPage.aspx?da=core&amp;id=%7B1EC226C2-8A70-4C08-985C-187EE58092BF%7D&amp;ed=FIELD17668611731&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H17668611880&amp;us=sitecore%5Canvi&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Giboney PT, Mildly elevated liver transaminase levels in the asymptomatic patient.. Am Fam Physician 2005;71: 1105-10" data-value-piped="Giboney PT|Mildly elevated liver transaminase levels in the asymptomatic patient.|Am Fam Physician|2005|71|1105-10|15791889" data-url="reference-link" data-pubmedid="15791889" title="Giboney PT, Mildly elevated liver transaminase levels in the asymptomatic patient.. Am Fam Physician 2005;71: 1105-10">3</a></h2>
<h3>Meget forh&oslash;jede v&aelig;rdier (10 gange over referenceintervallet, eller h&oslash;jere)</h3>
<ul>
    <li>Leversygdomme, som ogs&aring; medf&oslash;rer meget forh&oslash;jede v&aelig;rdier af&nbsp;<a href="~/link.aspx?_id=CAEF0A174B334B75805EB18D6A266EE1&amp;_z=z">P-ALAT</a>
    <ul>
        <li>ASAT har en kortere halveringstid i plasma (12-17 timer) end ALAT (36-47 timer), og vil derfor falde hurtigere, n&aring;r en sygdomstilstand stabiliseres eller bedres<a href="%20" title="Thomas L (ed). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998" data-url="reference-link" data-value="Thomas L (ed). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998" data-type="book-reference" data-value-piped="Thomas L (ed)|Clinical laboratory diagnostics. Use and assessment of clinical laboratory results|Frankfurt am Main|TH-Books Verlagsgesellschaft mbH|1998">1</a></li>
    </ul>
    </li>
    <li>Skader p&aring; og sygdomme i muskelv&aelig;v, som ogs&aring; medf&oslash;rer meget forh&oslash;jede v&aelig;rdier af&nbsp;<a href="~/link.aspx?_id=8545150E07124B06B73B5F0C390FAC33&amp;_z=z">P-Kreatinkinase (CK)</a></li>
    <li>Sv&aelig;rt p&aring;virket almentilstand med multiorgansvigt</li>
</ul>
<h3>Moderat forh&oslash;jede v&aelig;rdier (5-10 gange over referenceintervallet)</h3>
<ul>
    <li>Samme tilstande, som ogs&aring; medf&oslash;rer moderat forh&oslash;jede v&aelig;rdier af&nbsp;<a href="~/link.aspx?_id=CAEF0A174B334B75805EB18D6A266EE1&amp;_z=z">P-ALAT</a>&nbsp;eller&nbsp;<a href="~/link.aspx?_id=8545150E07124B06B73B5F0C390FAC33&amp;_z=z">P-Kreatinkinase (CK)</a></li>
    <li>Akut myokardieinfarkt</li>
</ul>
<h3>Let forh&oslash;jede v&aelig;rdier (2-5 gange over referenceintervallet)</h3>
<ul>
    <li>Samme tilstande, som ogs&aring; medf&oslash;rer let forh&oslash;jede v&aelig;rdier af&nbsp;<a href="~/link.aspx?_id=CAEF0A174B334B75805EB18D6A266EE1&amp;_z=z">P-ALAT</a>&nbsp;eller&nbsp;<a href="~/link.aspx?_id=8545150E07124B06B73B5F0C390FAC33&amp;_z=z">P-Kreatinkinase (CK)</a></li>
    <li>Hvis der b&aring;de findes let forh&oslash;jet P-ASAT og P-ALAT, vil ratioen ASAT/ALAT oftest v&aelig;re &gt; 2 hvis:
    <ul>
        <li>Enzymerne stammer fra en ikke-hepatisk kilde</li>
        <li>En leverp&aring;virkning er alkoholisk betinget, snarere end non-alkoholisk<a href="EditorPage.aspx?da=core&amp;id=%7B1EC226C2-8A70-4C08-985C-187EE58092BF%7D&amp;ed=FIELD17668611731&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H17668611880&amp;us=sitecore%5Canvi&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Green RM, Flamm S, AGA technical review on the evaluation of liver chemistry tests.. Gastroenterology 2002;123: 1367-84" data-value-piped="Green RM, Flamm S|AGA technical review on the evaluation of liver chemistry tests.|Gastroenterology|2002|123|1367-84|12360498" data-url="reference-link" data-pubmedid="12360498" title="Green RM, Flamm S, AGA technical review on the evaluation of liver chemistry tests.. Gastroenterology 2002;123: 1367-84">2</a><sup>,</sup><a href="EditorPage.aspx?da=core&amp;id=%7B1EC226C2-8A70-4C08-985C-187EE58092BF%7D&amp;ed=FIELD17668611731&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H17668611880&amp;us=sitecore%5Canvi&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Giboney PT, Mildly elevated liver transaminase levels in the asymptomatic patient.. Am Fam Physician 2005;71: 1105-10" data-value-piped="Giboney PT|Mildly elevated liver transaminase levels in the asymptomatic patient.|Am Fam Physician|2005|71|1105-10|15791889" data-url="reference-link" data-pubmedid="15791889" title="Giboney PT, Mildly elevated liver transaminase levels in the asymptomatic patient.. Am Fam Physician 2005;71: 1105-10">3</a></li>
    </ul>
    </li>
    <li>H&aelig;molytiske tilstande</li>
    <li>Pancreatitis</li>
    <li>Vedvarende let forh&oslash;jede v&aelig;rdier uden p&aring;viselig sygdom kan i sj&aelig;ldne tilf&aelig;lde skyldes cirkulerende komplekser af enzymet og et immunoglobulin ("makro-ASAT")<a href="%20" title="Thomas L (ed). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998" data-url="reference-link" data-value="Thomas L (ed). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998" data-type="book-reference" data-value-piped="Thomas L (ed)|Clinical laboratory diagnostics. Use and assessment of clinical laboratory results|Frankfurt am Main|TH-Books Verlagsgesellschaft mbH|1998">1</a></li>
</ul>
<h3>Ratios</h3>
<ul>
    <li>ASAT kan ses i forhold til andre parametre, eksempelvis&nbsp;<a href="~/link.aspx?_id=CAEF0A174B334B75805EB18D6A266EE1&amp;_z=z">P-ALAT</a>&nbsp;og P-LDH<a href="EditorPage.aspx?da=core&amp;id=%7B1EC226C2-8A70-4C08-985C-187EE58092BF%7D&amp;ed=FIELD314518500&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H314522911&amp;us=sitecore%5Cneho&amp;mo&amp;pe=0&amp;fbd=1#" title="Thomas L (ed). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998" data-url="reference-link" data-value="Thomas L (ed). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998" data-type="book-reference" data-value-piped="Thomas L (ed)|Clinical laboratory diagnostics. Use and assessment of clinical laboratory results|Frankfurt am Main|TH-Books Verlagsgesellschaft mbH|1998">1</a>&nbsp;og&nbsp;<a href="~/link.aspx?_id=8CCD398D12C84876A00F3D0A561F38A6&amp;_z=z">7</a><sup>,</sup><a href="EditorPage.aspx?da=core&amp;id=%7B1EC226C2-8A70-4C08-985C-187EE58092BF%7D&amp;ed=FIELD17668611731&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H17668611880&amp;us=sitecore%5Canvi&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Ünlüsoy Aksu A, Sarı S, Yılmaz G, Eğritaş Gürkan Ö, Demirtaş Z, Dalgıç B, Aspartate aminotransferase-to-platelet ratio index in children with cholestatic liver diseases to assess liver fibrosis.. Turk J Pediatr 2015;57: 492-7" data-value-piped="Ünlüsoy Aksu A, Sarı S, Yılmaz G, Eğritaş Gürkan Ö, Demirtaş Z, Dalgıç B|Aspartate aminotransferase-to-platelet ratio index in children with cholestatic liver diseases to assess liver fibrosis.|Turk J Pediatr|2015|57|492-7|27411417" data-url="reference-link" data-pubmedid="27411417" title="Ünlüsoy Aksu A, Sarı S, Yılmaz G, Eğritaş Gürkan Ö, Demirtaş Z, Dalgıç B, Aspartate aminotransferase-to-platelet ratio index in children with cholestatic liver diseases to assess liver fibrosis.. Turk J Pediatr 2015;57: 492-7">5</a></li>
</ul>
<h3>Normale v&aelig;rdier</h3>
<ul>
    <li>Udelukker IKKE let leverp&aring;virkning eller anden sygdom</li>
</ul>
<h3>Lave v&aelig;rdier</h3>
<ul>
    <li>Har ingen selvst&aelig;ndig klinisk betydning, men kan f.eks. ses ved nyresvigt<a href="EditorPage.aspx?da=core&amp;id=%7B1EC226C2-8A70-4C08-985C-187EE58092BF%7D&amp;ed=FIELD17668611731&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H17668611880&amp;us=sitecore%5Canvi&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Green RM, Flamm S, AGA technical review on the evaluation of liver chemistry tests.. Gastroenterology 2002;123: 1367-84" data-value-piped="Green RM, Flamm S|AGA technical review on the evaluation of liver chemistry tests.|Gastroenterology|2002|123|1367-84|12360498" data-url="reference-link" data-pubmedid="12360498" title="Green RM, Flamm S, AGA technical review on the evaluation of liver chemistry tests.. Gastroenterology 2002;123: 1367-84">2</a></li>
</ul>
<h2>Fejlkilder (og kilder til normal variation)</h2>
<ul>
    <li>Kraftig fysisk aktivitet i dagene f&oslash;r pr&oslash;vetagningen kan give forh&oslash;jede v&aelig;rdier</li>
    <li>H&aelig;molyse giver falsk forh&oslash;jede v&aelig;rdier</li>
    <li>Langvarig stase i forbindelse med pr&oslash;vetagningen kan give falsk forh&oslash;jede v&aelig;rdier</li>
    <li>Et meget proteinholdigt m&aring;ltid kan &oslash;ge v&aelig;rdierne med 20 % i de f&oslash;lgende timer<a href="%20" title="Thomas L (ed). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998" data-url="reference-link" data-value="Thomas L (ed). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998" data-type="book-reference" data-value-piped="Thomas L (ed)|Clinical laboratory diagnostics. Use and assessment of clinical laboratory results|Frankfurt am Main|TH-Books Verlagsgesellschaft mbH|1998">1</a></li>
</ul>
<h2>Biokemisk baggrund</h2>
<ul>
    <li>ASAT forekommer is&aelig;r i lever- og muskelv&aelig;v (inkl. myokardium), men ogs&aring; i nyrer, hjernen, pankreas, lunger, leukocytter og erytrocytter<a href="%20" title="Thomas L (ed). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998" data-url="reference-link" data-value="Thomas L (ed). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998" data-type="book-reference" data-value-piped="Thomas L (ed)|Clinical laboratory diagnostics. Use and assessment of clinical laboratory results|Frankfurt am Main|TH-Books Verlagsgesellschaft mbH|1998">1</a>. Analysen blev tidligere anvendt som hjerte og lever biomark&oslash;r</li>
    <li>I hepatocytter findes ASAT dels som et isoenzym lokaliseret til cytoplasma og dels som et isoenzym i mitokondrierne (m-ASAT). Det sidstn&aelig;vnte optr&aelig;der is&aelig;r i plasma ved udtalt cellenekrose<a href="%20" title="Thomas L (ed). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998" data-url="reference-link" data-value="Thomas L (ed). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998" data-type="book-reference" data-value-piped="Thomas L (ed)|Clinical laboratory diagnostics. Use and assessment of clinical laboratory results|Frankfurt am Main|TH-Books Verlagsgesellschaft mbH|1998">1</a></li>
</ul>
<h2>Pr&oslash;vetagning</h2>
<ul>
    <li>Veneblodpr&oslash;ve</li>
    <li>Pr&oslash;vetagningsr&oslash;r med heparin (til plasma) eller r&oslash;r uden antikoagulans (til serum)</li>
    <li>Afpipetteret plasma/serum er stabilt i op til en uge i k&oslash;leskab, men kan godt sendes med almindelig post til laboratoriet</li>
</ul>
<h2>Referenceintervaller</h2>
<ul>
    <li>0 d - 1 m&aring;ned: 20-100 U/L</li>
    <li>1 m&aring;ned - 1 &aring;r: 15-65 U/L</li>
    <li>1 &aring;r - 12 &aring;r: 10-60 U/L</li>
    <li>Kvinder 12 &aring;r - 18 &aring;r: 10-60 U/L</li>
    <li>Kvinder over 18 &aring;r: 15-35 U/L</li>
    <li>M&aelig;nd 12 - 18 &aring;r: 15-45 U/L</li>
    <li>M&aelig;nd over 18 &aring;r: 15-45 U/L
    </li>
    <li>Hos gravide ses 10-15 % h&oslash;jere v&aelig;rdier i 3. trimester og v&aelig;rdier op til 110 U/L i forbindelse med f&oslash;dslen<a href="%20" title="Klajnbard A, Szecsi PB, Colov NP, Andersen MR, Jorgensen M, Bjorngaard B, et al, Laboratory reference intervals during pregnancy, delivery and the early postpartum period. Clin Chem Lab Med 2010;48: 237-48" data-url="reference-link" data-value="Klajnbard A, Szecsi PB, Colov NP, Andersen MR, Jorgensen M, Bjorngaard B, et al, Laboratory reference intervals during pregnancy, delivery and the early postpartum period. Clin Chem Lab Med 2010;48: 237-48" data-type="journal-reference" data-value-piped="Klajnbard A, Szecsi PB, Colov NP, Andersen MR, Jorgensen M, Bjorngaard B, et al|Laboratory reference intervals during pregnancy, delivery and the early postpartum period|Clin Chem Lab Med|2010|48|237-48">7</a></li>
</ul>
<h2>NPU-koder og -navne</h2>
<ul>
    <li>NPU19654 P&mdash;Aspartattransaminase; kat.k.(IFCC 2002) = ? U/L</li>
</ul>
<ul>
    <li><strong>Kort navn</strong>
    <ul>
        <li>Aspartattransaminase [ASAT];P</li>
    </ul>
    </li>
</ul>
<h2>Opf&oslash;lgning</h2>
<ul>
    <li>Afh&aelig;nger af den kliniske kontekst (se ovenfor)</li>
</ul>]]></HtmlField>
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