asat (LH Indholdsside)

<Provider Id="sundheddkcms">
  <Item Id="{1EC226C2-8A70-4C08-985C-187EE58092BF}" Name="asat" Type="LHContentPage" ParentProviderId="sundheddkcms" ParentItemId="{954990FB-BCA1-4322-A1A9-62D3FD4B2E07}" SortOrder="1500" PublishDate="2010-04-07T13:08:00" DeleteDate="2999-12-31T00:00:00" PotItemType="">
    <Content>
      <HtmlField Name="PageContent"><![CDATA[<h2>Definition</h2>
<ul>
    <li>Koncentrationen af enzymet <strong>as</strong>partat-<strong>a</strong>mino<strong>t</strong>ransferase (ASAT i plasma, m&aring;lt som enheder (units) af dets katalytiske aktivitet per liter (U/L))</li>
</ul>
<h2>Synonymer</h2>
<ul>
    <li>P- eller S-ASAT; aspartattransaminase (AST); glutamyl-oxaloacetat transaminase (GOT);&nbsp;</li>
</ul>
<h2>Fortolkninger<a href="EditorPage.aspx?da=core&amp;id=%7B1EC226C2-8A70-4C08-985C-187EE58092BF%7D&amp;ed=FIELD1148509674&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H1148510818&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Patel K, Asrani SK, Fiel MI, Levine D, Leung DH, Duarte-Rojo A, Dranoff JA, Nayfeh T, Hasan B, Taddei TH, Alsawaf Y, Saadi S, Majzoub AM, Manolopoulos A, Alzuabi M, Ding J, Sofiyeva N, Murad MH, Alsawas M, Rockey DC, Sterling RK, Accuracy of blood-based biomarkers for staging liver fibrosis in chronic liver disease: A systematic review supporting the AASLD Practice Guideline. Hepatology 2025;81: 358-379" data-value-piped="Patel K, Asrani SK, Fiel MI, Levine D, Leung DH, Duarte-Rojo A, Dranoff JA, Nayfeh T, Hasan B, Taddei TH, Alsawaf Y, Saadi S, Majzoub AM, Manolopoulos A, Alzuabi M, Ding J, Sofiyeva N, Murad MH, Alsawas M, Rockey DC, Sterling RK|Accuracy of blood-based biomarkers for staging liver fibrosis in chronic liver disease: A systematic review supporting the AASLD Practice Guideline.|Hepatology|2025|81|358-379|38489517" data-url="reference-link" data-pubmedid="38489517" title="Patel K, Asrani SK, Fiel MI, Levine D, Leung DH, Duarte-Rojo A, Dranoff JA, Nayfeh T, Hasan B, Taddei TH, Alsawaf Y, Saadi S, Majzoub AM, Manolopoulos A, Alzuabi M, Ding J, Sofiyeva N, Murad MH, Alsawas M, Rockey DC, Sterling RK, Accuracy of blood-based biomarkers for staging liver fibrosis in chronic liver disease: A systematic review supporting the AASLD Practice Guideline. Hepatology 2025;81: 358-379"><sup>1</sup></a><sup>,</sup><a href="EditorPage.aspx?da=core&amp;id=%7B1EC226C2-8A70-4C08-985C-187EE58092BF%7D&amp;ed=FIELD17668611731&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H17668611880&amp;us=sitecore%5Canvi&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Green RM, Flamm S, AGA technical review on the evaluation of liver chemistry tests.. Gastroenterology 2002;123: 1367-84" data-value-piped="Green RM, Flamm S|AGA technical review on the evaluation of liver chemistry tests.|Gastroenterology|2002|123|1367-84|12360498" data-url="reference-link" data-pubmedid="12360498" title="Green RM, Flamm S, AGA technical review on the evaluation of liver chemistry tests.. Gastroenterology 2002;123: 1367-84"><sup>2</sup></a><sup>,</sup><a href="EditorPage.aspx?da=core&amp;id=%7B1EC226C2-8A70-4C08-985C-187EE58092BF%7D&amp;ed=FIELD17668611731&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H17668611880&amp;us=sitecore%5Canvi&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Giboney PT, Mildly elevated liver transaminase levels in the asymptomatic patient.. Am Fam Physician 2005;71: 1105-10" data-value-piped="Giboney PT|Mildly elevated liver transaminase levels in the asymptomatic patient.|Am Fam Physician|2005|71|1105-10|15791889" data-url="reference-link" data-pubmedid="15791889" title="Giboney PT, Mildly elevated liver transaminase levels in the asymptomatic patient.. Am Fam Physician 2005;71: 1105-10"><sup>3</sup></a></h2>
<ul>
    <li>Analysen fortolkes ikke alene, men har v&aelig;rdi i algoritmen til&nbsp;<a href="~/link.aspx?_id=75EB2C747EE04008BCAE16072A7C2C82&amp;_z=z">FIB-4</a><a href="EditorPage.aspx?da=core&amp;id=%7B1EC226C2-8A70-4C08-985C-187EE58092BF%7D&amp;ed=FIELD1148509674&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H1148510818&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Patel K, Asrani SK, Fiel MI, Levine D, Leung DH, Duarte-Rojo A, Dranoff JA, Nayfeh T, Hasan B, Taddei TH, Alsawaf Y, Saadi S, Majzoub AM, Manolopoulos A, Alzuabi M, Ding J, Sofiyeva N, Murad MH, Alsawas M, Rockey DC, Sterling RK, Accuracy of blood-based biomarkers for staging liver fibrosis in chronic liver disease: A systematic review supporting the AASLD Practice Guideline. Hepatology 2025;81: 358-379" data-value-piped="Patel K, Asrani SK, Fiel MI, Levine D, Leung DH, Duarte-Rojo A, Dranoff JA, Nayfeh T, Hasan B, Taddei TH, Alsawaf Y, Saadi S, Majzoub AM, Manolopoulos A, Alzuabi M, Ding J, Sofiyeva N, Murad MH, Alsawas M, Rockey DC, Sterling RK|Accuracy of blood-based biomarkers for staging liver fibrosis in chronic liver disease: A systematic review supporting the AASLD Practice Guideline.|Hepatology|2025|81|358-379|38489517" data-url="reference-link" data-pubmedid="38489517" title="Patel K, Asrani SK, Fiel MI, Levine D, Leung DH, Duarte-Rojo A, Dranoff JA, Nayfeh T, Hasan B, Taddei TH, Alsawaf Y, Saadi S, Majzoub AM, Manolopoulos A, Alzuabi M, Ding J, Sofiyeva N, Murad MH, Alsawas M, Rockey DC, Sterling RK, Accuracy of blood-based biomarkers for staging liver fibrosis in chronic liver disease: A systematic review supporting the AASLD Practice Guideline. Hepatology 2025;81: 358-379"><sup>1</sup></a></li>
    <li>Forh&oslash;jede v&aelig;rdier ses ved sygdomme, som ogs&aring; medf&oslash;rer meget forh&oslash;jede v&aelig;rdier af&nbsp;<a href="~/link.aspx?_id=CAEF0A174B334B75805EB18D6A266EE1&amp;_z=z">P-ALAT</a>&nbsp;og&nbsp;&nbsp;<a href="~/link.aspx?_id=8545150E07124B06B73B5F0C390FAC33&amp;_z=z">P-Kreatinkinase (CK)</a></li>
    <li>ASAT har en kortere halveringstid i plasma (12-17 timer) end ALAT (36-47 timer), og vil derfor falde hurtigere, n&aring;r en sygdomstilstand stabiliseres eller bedres</li>
    <li>Udelukker IKKE let leverp&aring;virkning eller anden sygdom</li>
    <li>Vedvarende let forh&oslash;jede v&aelig;rdier uden p&aring;viselig sygdom kan i sj&aelig;ldne tilf&aelig;lde skyldes cirkulerende komplekser af enzymet og et immunoglobulin ("makro-ASAT")<a href="%20" title="Thomas L (ed). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998" data-url="reference-link" data-value="Thomas L (ed). Clinical laboratory diagnostics. Use and assessment of clinical laboratory results. Frankfurt am Main: TH-Books Verlagsgesellschaft mbH; 1998" data-type="book-reference" data-value-piped="Thomas L (ed)|Clinical laboratory diagnostics. Use and assessment of clinical laboratory results|Frankfurt am Main|TH-Books Verlagsgesellschaft mbH|1998"><sup>4</sup></a></li>
</ul>
<h3>Ratios</h3>
<ul>
    <li>ASAT kan ses i forhold til andre parametre, eksempelvis&nbsp;<a href="~/link.aspx?_id=CAEF0A174B334B75805EB18D6A266EE1&amp;_z=z">P-ALAT</a>&nbsp;og&nbsp; trombocytter<a href=" " data-type="journal-reference" data-value="Brits E, Brown S, Botes L, Sempa JB, Pienaar M, Aspartate Aminotransferase-to-platelet Ratio Index (APRi) as Biomarker for Liver Damage in Biliary Atresia (BA): A Meta-analysis. J Pediatr Surg 2025;60: 162234" data-value-piped="Brits E, Brown S, Botes L, Sempa JB, Pienaar M|Aspartate Aminotransferase-to-platelet Ratio Index (APRi) as Biomarker for Liver Damage in Biliary Atresia (BA): A Meta-analysis.|J Pediatr Surg|2025|60|162234|39923745" data-url="reference-link" data-pubmedid="39923745" title="Brits E, Brown S, Botes L, Sempa JB, Pienaar M, Aspartate Aminotransferase-to-platelet Ratio Index (APRi) as Biomarker for Liver Damage in Biliary Atresia (BA): A Meta-analysis. J Pediatr Surg 2025;60: 162234"><sup>5</sup></a></li>
</ul>
<h3>Fejlkilder (og kilder til normal variation)</h3>
<ul>
    <li>Kraftig fysisk aktivitet i dagene f&oslash;r pr&oslash;vetagningen kan give forh&oslash;jede v&aelig;rdier</li>
    <li>H&aelig;molyse giver falsk forh&oslash;jede v&aelig;rdier</li>
    <li>Langvarig stase i forbindelse med pr&oslash;vetagningen kan give falsk forh&oslash;jede v&aelig;rdier</li>
</ul>
<h2>Fysiologi og biokemi</h2>
<ul>
    <li>ASAT forekommer is&aelig;r i lever- og muskelv&aelig;v (inkl. myokardium), men ogs&aring; i nyrer, hjernen, pankreas, lunger, leukocytter og erytrocytter. Analysen blev tidligere anvendt som hjerte og lever biomark&oslash;r</li>
    <li>I hepatocytter findes ASAT dels som et isoenzym lokaliseret til cytoplasma og dels som et isoenzym i mitokondrierne (m-ASAT). Det sidstn&aelig;vnte optr&aelig;der is&aelig;r i plasma ved udtalt cellenekrose</li>
</ul>
<h2>Pr&oslash;vetagning</h2>
<ul>
    <li>Veneblodpr&oslash;ve</li>
    <li>Pr&oslash;vetagningsr&oslash;r med heparin (til plasma) eller r&oslash;r uden antikoagulans (til serum)</li>
    <li>Afpipetteret plasma/serum er stabilt i op til en uge i k&oslash;leskab, men kan godt sendes med almindelig post til laboratoriet</li>
</ul>
<h2>Referenceintervaller</h2>
<ul>
    <li>0 d - 1 m&aring;ned: 20-100 U/L</li>
    <li>1 m&aring;ned - 1 &aring;r: 15-65 U/L</li>
    <li>1 &aring;r - 12 &aring;r: 10-60 U/L</li>
    <li>Kvinder 12 &aring;r - 18 &aring;r: 10-60 U/L</li>
    <li>Kvinder over 18 &aring;r: 15-35 U/L</li>
    <li>M&aelig;nd 12 - 18 &aring;r: 15-45 U/L</li>
    <li>M&aelig;nd over 18 &aring;r: 15-45 U/L
    </li>
    <li>Hos gravide ses 10-15 % h&oslash;jere v&aelig;rdier i 3. trimester og v&aelig;rdier op til 110 U/L i forbindelse med f&oslash;dslen<a href="%20" title="Klajnbard A, Szecsi PB, Colov NP, Andersen MR, Jorgensen M, Bjorngaard B, et al, Laboratory reference intervals during pregnancy, delivery and the early postpartum period. Clin Chem Lab Med 2010;48: 237-48" data-url="reference-link" data-value="Klajnbard A, Szecsi PB, Colov NP, Andersen MR, Jorgensen M, Bjorngaard B, et al, Laboratory reference intervals during pregnancy, delivery and the early postpartum period. Clin Chem Lab Med 2010;48: 237-48" data-type="journal-reference" data-value-piped="Klajnbard A, Szecsi PB, Colov NP, Andersen MR, Jorgensen M, Bjorngaard B, et al|Laboratory reference intervals during pregnancy, delivery and the early postpartum period|Clin Chem Lab Med|2010|48|237-48"><sup>6</sup></a></li>
</ul>
<h2>NPU-koder og -navne</h2>
<ul>
    <li>NPU19654</li>
</ul>
<ul>
    <li><strong>Kort helterm</strong>
    <ul>
        <li> P&mdash;Aspartattransaminase; kat.k.(IFCC 2002) = ? U/L</li>
    </ul>
    </li>
    <li><strong>Brugsnavn</strong>
    <ul>
        <li>Aspartattransaminase [ASAT];P</li>
    </ul>
    </li>
</ul>
<p>
</p>
<h2>Opf&oslash;lgning</h2>
<ul>
    <li>Sker hvis Fib-4 er p&aring;virket</li>
</ul>
<div id="teamshare-chrome-client-app-extension">&nbsp;</div>
<div id="teamshare-chrome-client-app-extension">&nbsp;</div>]]></HtmlField>
      <HtmlField Name="Resume"><![CDATA[<h2>Resum&eacute;</h2>
<ul>
    <li>Analysen finder kun anvendelse som et element i algoritmen&nbsp;<a href="~/link.aspx?_id=75EB2C747EE04008BCAE16072A7C2C82&amp;_z=z">FIB-4</a>&nbsp;(Fibrosis-4)<a href="EditorPage.aspx?da=core&amp;id=%7B1EC226C2-8A70-4C08-985C-187EE58092BF%7D&amp;ed=FIELD1148509674&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H1148510818&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Patel K, Asrani SK, Fiel MI, Levine D, Leung DH, Duarte-Rojo A, Dranoff JA, Nayfeh T, Hasan B, Taddei TH, Alsawaf Y, Saadi S, Majzoub AM, Manolopoulos A, Alzuabi M, Ding J, Sofiyeva N, Murad MH, Alsawas M, Rockey DC, Sterling RK, Accuracy of blood-based biomarkers for staging liver fibrosis in chronic liver disease: A systematic review supporting the AASLD Practice Guideline. Hepatology 2025;81: 358-379" data-value-piped="Patel K, Asrani SK, Fiel MI, Levine D, Leung DH, Duarte-Rojo A, Dranoff JA, Nayfeh T, Hasan B, Taddei TH, Alsawaf Y, Saadi S, Majzoub AM, Manolopoulos A, Alzuabi M, Ding J, Sofiyeva N, Murad MH, Alsawas M, Rockey DC, Sterling RK|Accuracy of blood-based biomarkers for staging liver fibrosis in chronic liver disease: A systematic review supporting the AASLD Practice Guideline.|Hepatology|2025|81|358-379|38489517" data-url="reference-link" data-pubmedid="38489517" title="Patel K, Asrani SK, Fiel MI, Levine D, Leung DH, Duarte-Rojo A, Dranoff JA, Nayfeh T, Hasan B, Taddei TH, Alsawaf Y, Saadi S, Majzoub AM, Manolopoulos A, Alzuabi M, Ding J, Sofiyeva N, Murad MH, Alsawas M, Rockey DC, Sterling RK, Accuracy of blood-based biomarkers for staging liver fibrosis in chronic liver disease: A systematic review supporting the AASLD Practice Guideline. Hepatology 2025;81: 358-379"><sup>1</sup></a>&nbsp;til estimering af leverfibrose, og udf&oslash;res derfor ikke p&aring; alle laboratorier</li>
    <li>Uspecifik mark&oslash;r for skade p&aring;&nbsp;flere typer v&aelig;v</li>
    <li>Den udf&oslash;res ellers mest i forbindelse med forskningsprojekter&nbsp;</li>
</ul>]]></HtmlField>
      <LinkListField Name="Spot2">
        <LinkField linktype="internal">{99A85AFD-2F7A-4B5D-A1C9-C2701D5E7D30}</LinkField>
      </LinkListField>
      <TextField Name="DoctorsHandbookID">2949</TextField>
      <TextField Name="PageTitle">ASAT</TextField>
      <TextField Name="NavigationTitle">ASAT</TextField>
      <CheckBoxField Name="ShowInMenu">true</CheckBoxField>
      <CheckBoxField Name="ShowInContentField">true</CheckBoxField>
      <DateTimeField Name="RevisedDate">2025-07-29T14:58:00</DateTimeField>
      <LinkListField Name="Authors">
        <LinkField linktype="internal">{E3258509-7DFB-4092-BE9F-B584BD8A18BA}</LinkField>
        <LinkField linktype="internal">{FDEF4DBD-AAF0-4AF0-82F7-983F8710B93E}</LinkField>
      </LinkListField>
      <LinkListField Name="Organization">
        <LinkField linktype="internal">{CF77E8B9-9937-42B2-85DF-76B0F4E401F0}</LinkField>
      </LinkListField>
      <LinkListField Name="SearchAreaID">
        <LinkField linktype="internal">3</LinkField>
      </LinkListField>
      <TextField Name="Description">ASAT-blodprøve er en uspecifik markør for skade på flere typer væv</TextField>
      <LinkListField Name="LHPHEditor">
        <LinkField linktype="internal">{C70DFB71-BE40-455A-BD6B-5AFF199797D9}</LinkField>
      </LinkListField>
      <TextField Name="__Updated by">sitecore\Niko</TextField>
      <TextField Name="MetaKeywords">ASAT, aspartataminotransferase, Levertal, aspartattransaminase, ast, glutamyl-oxaloacetat transaminase, got</TextField>
      <LinkListField Name="InformationCategory">
        <LinkField linktype="internal">IC_3</LinkField>
      </LinkListField>
      <LinkListField Name="InformationType">
        <LinkField linktype="internal">7</LinkField>
      </LinkListField>
      <LinkListField Name="SearchTargetGroup">
        <LinkField linktype="internal">2</LinkField>
      </LinkListField>
    </Content>
    <Medias />
  </Item>
</Provider>

15.686 characters