carcinoembryonalt-antigen-cea (LH Indholdsside)

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      <HtmlField Name="PageContent"><![CDATA[<h2>Resum&eacute;</h2>
<ul>
    <li>Carcinoembryonalt antigen (CEA) er en tumormark&oslash;r, til monitorering af behandlingsforl&oslash;bet&nbsp;hos patienter&nbsp;med CEA-positiv cancer: Prim&aelig;rt coloncancer,&nbsp;men&nbsp;ogs&aring;&nbsp;bryst-, lunge-,&nbsp;pancreas-, ventrikel- og gyn&aelig;kologisk cancer<a href="/EditorPage.aspx?da=core&amp;id=%7B6079169D-6BB5-466E-A0FC-6530F81A352A%7D&amp;ed=FIELD3041083561&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H3041083776&amp;mo&amp;pe=0&amp;fbd=1#" title="Nilsson-Ehle P (red). Laurells klinisk kemi i praktisk medicin. 9. udg. Lund: Studentlitteratur; 2012" data-url="reference-link" data-value="Nilsson-Ehle P (red). Laurells klinisk kemi i praktisk medicin. 9. udg. Lund: Studentlitteratur; 2012" data-type="book-reference" data-value-piped="Nilsson-Ehle P (red)|Laurells klinisk kemi i praktisk medicin. 9. udg|Lund|Studentlitteratur|2012">1</a><sup>,</sup><a href="/EditorPage.aspx?da=core&amp;id=%7B6079169D-6BB5-466E-A0FC-6530F81A352A%7D&amp;ed=FIELD3041083561&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H3041083776&amp;mo&amp;pe=0&amp;fbd=1#" title="Lyngbye J, Kjær A, Ladefoged SA, Nissen PH. Lyngbyes laboratoriemedicin. 2. udg.. København: Nyt Nordisk Forlag Arnold Busck A/S; 2010" data-url="reference-link" data-value="Lyngbye J, Kjær A, Ladefoged SA, Nissen PH. Lyngbyes laboratoriemedicin. 2. udg.. København: Nyt Nordisk Forlag Arnold Busck A/S; 2010" data-type="book-reference" data-value-piped="Lyngbye J, Kjær A, Ladefoged SA, Nissen PH|Lyngbyes laboratoriemedicin. 2. udg.|København|Nyt Nordisk Forlag Arnold Busck A/S|2010">2</a></li>
    <li>Forh&oslash;jet CEA ved kolorektalcancer er associeret med udbredt cancer og manglende fald &nbsp;efter kirurgi indikerer rest sygdom eller recidiv</li>
</ul>
<h2>Definition</h2>
<ul>
    <li>Koncentrationen af carcinoembryonalt antigen (CEA) i serum, m&aring;lt i &micro;g/L </li>
</ul>
<h2>Synonymer</h2>
<ul>
    <li>Synonymer: Ce-Ag</li>
</ul>
<h2>Indikationer<a href=" " data-type="journal-reference" data-value="Hall C, Clarke L, Pal A, Buchwald P, Eglinton T, Wakeman C, Frizelle F, A Review of the Role of Carcinoembryonic Antigen in Clinical Practice. Ann Coloproctol 2019;35: 294-305" data-value-piped="Hall C, Clarke L, Pal A, Buchwald P, Eglinton T, Wakeman C, Frizelle F|A Review of the Role of Carcinoembryonic Antigen in Clinical Practice.|Ann Coloproctol|2019|35|294-305|31937069" data-url="reference-link" data-pubmedid="31937069" title="Hall C, Clarke L, Pal A, Buchwald P, Eglinton T, Wakeman C, Frizelle F, A Review of the Role of Carcinoembryonic Antigen in Clinical Practice. Ann Coloproctol 2019;35: 294-305">3</a></h2>
<h3>Colorectalcancer</h3>
<ul>
    <li>Monitorering og behandlingskontrol (fx kemoterapi) af&nbsp;<a href="~/link.aspx?_id=3878D118D7204DA7ADC2DDA60921DA71&amp;_z=z">colorectalcancer</a>&nbsp;med henblik p&aring; tidlig recidivopsporing
    <ul>
        <li>Ofte serielle m&aring;linger de f&oslash;rste 2 &aring;r, herefter &aring;rligt i 3 &aring;r</li>
        <li>CEA-&oslash;gning med mere end 30 % i 2 pr&oslash;ver med en m&aring;neds mellemrum tyder p&aring; metastaser eller recidiv ca. 3 m&aring;neder f&oslash;r, der kommer kliniske tegn</li>
    </ul>
    </li>
    <li>Pr&aelig;operativ prognostisk mark&oslash;r</li>
    <li>Til vurdering af resttumorbyrden efter prim&aelig;r behandling</li>
    <li>Postoperativ prognostisk mark&oslash;r &ndash; h&oslash;je niveauer postoperativt er forbundet med d&aring;rlig 5-&aring;rs overlevelse</li>
</ul>
<h3>Andre cancerformer<a href=" " data-type="journal-reference" data-value="Passos I, Stefanidou E, Meditskou-Eythymiadou S, Mironidou-Tzouveleki M, Manaki V, Magra V, Laskou S, Mantalovas S, Pantea S, Kesisoglou I, Sapalidis K, A Review of the Significance in Measuring Preoperative and Postoperative Carcinoembryonic Antigen (CEA) Values in Patients with Medullary Thyroid Carcinoma (MTC). Medicina (Kaunas) 2021;57: " data-value-piped="Passos I, Stefanidou E, Meditskou-Eythymiadou S, Mironidou-Tzouveleki M, Manaki V, Magra V, Laskou S, Mantalovas S, Pantea S, Kesisoglou I, Sapalidis K|A Review of the Significance in Measuring Preoperative and Postoperative Carcinoembryonic Antigen (CEA) Values in Patients with Medullary Thyroid Carcinoma (MTC).|Medicina (Kaunas)|2021|57||34208296" data-url="reference-link" data-pubmedid="34208296" title="Passos I, Stefanidou E, Meditskou-Eythymiadou S, Mironidou-Tzouveleki M, Manaki V, Magra V, Laskou S, Mantalovas S, Pantea S, Kesisoglou I, Sapalidis K, A Review of the Significance in Measuring Preoperative and Postoperative Carcinoembryonic Antigen (CEA) Values in Patients with Medullary Thyroid Carcinoma (MTC). Medicina (Kaunas) 2021;57: ">4</a><sup>,</sup><a href=" " data-type="journal-reference" data-value="Seale KN, Tkaczuk KHR, Circulating Biomarkers in Breast Cancer. Clin Breast Cancer 2022;22: e319-e331" data-value-piped="Seale KN, Tkaczuk KHR|Circulating Biomarkers in Breast Cancer.|Clin Breast Cancer|2022|22|e319-e331|34756687" data-url="reference-link" data-pubmedid="34756687" title="Seale KN, Tkaczuk KHR, Circulating Biomarkers in Breast Cancer. Clin Breast Cancer 2022;22: e319-e331">5</a><sup>,</sup><a href=" " data-type="journal-reference" data-value="Chai X, Yinwang E, Wang Z, Wang Z, Xue Y, Li B, Zhou H, Zhang W, Wang S, Zhang Y, Li H, Mou H, Sun L, Qu H, Wang F, Zhang Z, Chen T, Ye Z, Predictive and Prognostic Biomarkers for Lung Cancer Bone Metastasis and Their Therapeutic Value. Front Oncol 2021;11: 692788" data-value-piped="Chai X, Yinwang E, Wang Z, Wang Z, Xue Y, Li B, Zhou H, Zhang W, Wang S, Zhang Y, Li H, Mou H, Sun L, Qu H, Wang F, Zhang Z, Chen T, Ye Z|Predictive and Prognostic Biomarkers for Lung Cancer Bone Metastasis and Their Therapeutic Value.|Front Oncol|2021|11|692788|34722241" data-url="reference-link" data-pubmedid="34722241" title="Chai X, Yinwang E, Wang Z, Wang Z, Xue Y, Li B, Zhou H, Zhang W, Wang S, Zhang Y, Li H, Mou H, Sun L, Qu H, Wang F, Zhang Z, Chen T, Ye Z, Predictive and Prognostic Biomarkers for Lung Cancer Bone Metastasis and Their Therapeutic Value. Front Oncol 2021;11: 692788">6</a></h3>
<ul>
    <li>Kan eventuel bruges til monitorering og behandlingskontrol (fx kemoterapi) af pancreas-, lunge-, medull&aelig;r thyreoidea-, ventrikel- og mammacancer med henblik p&aring; tidlig recidivopsporing</li>
</ul>
<h3>Screening af asymptomatiske</h3>
<ul>
    <li>Kan ikke anvendes til screening af asymptomatiske personer. Har en ikke-symptomatisk person forh&oslash;jet CEA, b&oslash;r der ses efter tegn p&aring; CEA producerende benigne/maligne sygdomme. Eventuel rygning b&oslash;r oph&oslash;re og CEA gentages efter 3 m&aring;neder&nbsp;<a href="EditorPage.aspx?da=core&amp;id=%7B6079169D-6BB5-466E-A0FC-6530F81A352A%7D&amp;ed=FIELD3041083561&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H3041083776&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Hall C, Clarke L, Pal A, Buchwald P, Eglinton T, Wakeman C, Frizelle F, A Review of the Role of Carcinoembryonic Antigen in Clinical Practice. Ann Coloproctol 2019;35: 294-305" data-value-piped="Hall C, Clarke L, Pal A, Buchwald P, Eglinton T, Wakeman C, Frizelle F|A Review of the Role of Carcinoembryonic Antigen in Clinical Practice.|Ann Coloproctol|2019|35|294-305|31937069" data-url="reference-link" data-pubmedid="31937069" title="Hall C, Clarke L, Pal A, Buchwald P, Eglinton T, Wakeman C, Frizelle F, A Review of the Role of Carcinoembryonic Antigen in Clinical Practice. Ann Coloproctol 2019;35: 294-305">3</a>
    &nbsp;</li>
</ul>
<h2>Fortolkninger<a href=" " data-type="journal-reference" data-value="Hall C, Clarke L, Pal A, Buchwald P, Eglinton T, Wakeman C, Frizelle F, A Review of the Role of Carcinoembryonic Antigen in Clinical Practice. Ann Coloproctol 2019;35: 294-305" data-value-piped="Hall C, Clarke L, Pal A, Buchwald P, Eglinton T, Wakeman C, Frizelle F|A Review of the Role of Carcinoembryonic Antigen in Clinical Practice.|Ann Coloproctol|2019|35|294-305|31937069" data-url="reference-link" data-pubmedid="undefined" title="Hall C, Clarke L, Pal A, Buchwald P, Eglinton T, Wakeman C, Frizelle F, A Review of the Role of Carcinoembryonic Antigen in Clinical Practice. Ann Coloproctol 2019;35: 294-305">3</a></h2>
<ul>
    <li>Organ- og v&aelig;vspecificitet er d&aring;rlig</li>
</ul>
<h3>Kolorektal cancer</h3>
<ul>
    <li>CEA v&aelig;rdien er ofte h&oslash;j ved kolorektal cancer</li>
    <li>
    <ul>
        <li>CEA er forh&oslash;jet hos 50 % af patienterne med lymfeknudemetastaser</li>
        <li>CEA er forh&oslash;jet (&gt;100 &mu;g/L) hos 75 % af patienterne med fjernmetastaser, herunder levermetastaser</li>
    </ul>
    </li>
    <li>Kun halvdelen af tilf&aelig;ldene med operabel kolorektalcancer har forh&oslash;jet CEA. Normal CEA udelukker s&aring;ledes ikke cancer, men tyder p&aring; bedre overlevelse</li>
    <li>Pr&aelig;operativ CEA niveau har prognostisk betydning
    <ul>
        <li>&nbsp;CEA &gt;10 &mu;g/L tyder p&aring; d&aring;rlig prognose</li>
    </ul>
    </li>
    <li>Postoperative niveauer 6&ndash;8 uger efter operationen afspejler resttumorbyrden, og serielle m&aring;linger kan opspore recidiv flere m&aring;neder f&oslash;r kliniske tegn</li>
</ul>
<h3>H&oslash;je v&aelig;rdier af CEA &gt;10 &mu;g/L</h3>
<ul>
    <li>CEA kan v&aelig;re forh&oslash;jet ved
    <ul>
        <li><a href="~/link.aspx?_id=DA70B1EE64FD4845B8B6EA2925908EC5&amp;_z=z">Lungecancer</a></li>
        <li><a href="~/link.aspx?_id=5E179A64BD87496DB67E5B4511436E72&amp;_z=z">Pancreascancer</a></li>
        <li><a href="~/link.aspx?_id=7B278E7B6B8646BDA306EBF00A4243A5&amp;_z=z">Ventrikelcancer</a></li>
        <li><a href="~/link.aspx?_id=E04E0DBEA64F4062A19CF67D1ADA2D8E&amp;_z=z">Mammacancer</a>&nbsp;</li>
        <li>Adenocarcinom</li>
        <li>Medull&aelig;r thyroidea carcinom</li>
    </ul>
    </li>
</ul>
<h3>Ikke &ndash; maligne tilstande</h3>
<h4>Let &oslash;gning i CEA (&gt;5 og &lt;10 &mu;g/L)</h4>
<ul>
    <li><a href="~/link.aspx?_id=E4952F1176A64A1F91299626791C4A3F&amp;_z=z">Levercirrose</a></li>
    <li><a href="~/link.aspx?_id=62540B9A858E40508D36FB82EDDEDD59&amp;_z=z">Colitis ulcerosa</a></li>
    <li>Lungeemfysem</li>
    <li><a href="~/link.aspx?_id=070168CC75D24A4E92AA2F2101F2E444&amp;_z=z">Cholecystitis</a></li>
    <li><a href="~/link.aspx?_id=E2AFE0134DBD4525ABA2C968A8DA7C52&amp;_z=z">Ulcus ventriculi&nbsp;</a>og ulcus duodeni</li>
    <li>Hypothyreose</li>
</ul>
<h3>Uspecifik &oslash;gning i CEA ses ved</h3>
<ul>
    <li>Rygning</li>
    <li>Infektioner</li>
    <li>Levercirrose</li>
    <li>Colitis ulcerosa</li>
    <li>Lungeemfysem</li>
    <li>Cholecystitis</li>
</ul>
<h2>Fejlkilder (og kilder til normal variation)</h2>
<ul>
    <li>Organ- og v&aelig;vspecificitet er d&aring;rlig og analysen b&oslash;r ikke anvendes til screening</li>
</ul>
<ul>
</ul>
<h2>Biokemisk baggrund<a href="EditorPage.aspx?da=core&amp;id=%7B6079169D-6BB5-466E-A0FC-6530F81A352A%7D&amp;ed=FIELD3041087406&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H3041087470&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Rizeq B, Zakaria Z, Ouhtit A, Towards understanding the mechanisms of actions of carcinoembryonic antigen-related cell adhesion molecule 6 in cancer progression. Cancer Sci 2018;109: 33-42" data-value-piped="Rizeq B, Zakaria Z, Ouhtit A|Towards understanding the mechanisms of actions of carcinoembryonic antigen-related cell adhesion molecule 6 in cancer progression.|Cancer Sci|2018|109|33-42|29110374" data-url="reference-link" data-pubmedid="29110374" title="Rizeq B, Zakaria Z, Ouhtit A, Towards understanding the mechanisms of actions of carcinoembryonic antigen-related cell adhesion molecule 6 in cancer progression. Cancer Sci 2018;109: 33-42">7</a><a href="/EditorPage.aspx?da=core&amp;id=%7B6079169D-6BB5-466E-A0FC-6530F81A352A%7D&amp;ed=FIELD3041083561&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H3041083776&amp;mo&amp;pe=0&amp;fbd=1#" title="Lyngbye J, Kjær A, Ladefoged SA, Nissen PH. Lyngbyes laboratoriemedicin. 2. udg.. København: Nyt Nordisk Forlag Arnold Busck A/S; 2010" data-url="reference-link" data-value="Lyngbye J, Kjær A, Ladefoged SA, Nissen PH. Lyngbyes laboratoriemedicin. 2. udg.. København: Nyt Nordisk Forlag Arnold Busck A/S; 2010" data-type="book-reference" data-value-piped="Lyngbye J, Kjær A, Ladefoged SA, Nissen PH|Lyngbyes laboratoriemedicin. 2. udg.|København|Nyt Nordisk Forlag Arnold Busck A/S|2010">2</a></h2>
<ul>
    <li>CEA er et f&oslash;talt glycoprotein, som er involveret i celleadh&aelig;sion. Det produceres is&aelig;r under den f&oslash;tale udvikling. Tilh&oslash;rer en stor familie af glycoproteiner, som er lokaliseret til celleoverflader</li>
    <li>Efter f&oslash;dslen sker produktionen is&aelig;r i epithelceller (columna) og i tyktarmsslimhinden. Findes i mindre grad i epithelceller i ventrikel, tyndtarm. prostata, svedkirtler og bl&aelig;re&nbsp;</li>
    <li>CEA er formentlig et cellul&aelig;rt adh&aelig;sionsmolekyle, der kan potensere invasion af cancer og metastaser</li>
</ul>
<h2>Pr&oslash;vetagning</h2>
<ul>
    <li>Veneblodpr&oslash;ve
    <ul>
        <li>Serum &ndash; r&oslash;r uden antikoagulans - r&oslash;d prop</li>
        <li>Plasma - heparin (se instruks fra lokal KBA)</li>
    </ul>
    </li>
</ul>
<h2>Referenceintervaller</h2>
<ul>
    <li>Ikke-rygere: &lt;4 &mu;g/L</li>
    <li>Rygere: &lt;6 &mu;g/L</li>
    <li>Referenceintervallet er afh&aelig;ngigt af analyseudstyr/analysemetode p&aring; den lokale biokemiske afdeling</li>
</ul>
<h2>NPU-koder og -navne</h2>
<ul>
    <li>NPU19719</li>
</ul>
<h3>Navne</h3>
<ul>
    <li><strong>Langt navn</strong>
    <ul>
        <li>P&mdash;Carcinoembryonalt antigen; massek. = ? &micro;g/L</li>
    </ul>
    </li>
    <li><strong>Kort navn</strong>
    <ul>
        <li>Carcinoembryonalt antigen;P</li>
    </ul>
    </li>
</ul>]]></HtmlField>
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