disialo-transferrin-cdt (LH Indholdsside)

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      <HtmlField Name="PageContent"><![CDATA[<h2>Definition</h2>
<ul>
    <li>Fraktionen af disialo-transferrin af den totale m&aelig;ngde af transferrin i plasma, dvs. alle isoformer med op til 5 sialsyrek&aelig;der&nbsp;</li>
</ul>
<h2>Synonymer</h2>
<ul>
    <li>Carbohydrat-deficient transferrin; CDT; % CDT; Karbohydratfattigt transferrin; Sialsyrefattigt transferrin; Desialiseret transferrin; Deglykoliseret transferrin</li>
</ul>
<h2>Indikationer</h2>
<ul>
    <li>Analysen anvendes n&aelig;sten ikke i Danmark, fordi den er teknisk kr&aelig;vende og relativt dyr at udf&oslash;re</li>
    <li>Den kan have en plads i udredning og kontrol af patienter, som mist&aelig;nkes for at have et&nbsp;<a href="~/link.aspx?_id=C080DD40EC4E4DAEAEDF4AC362930D12&amp;_z=z">h&oslash;jt alkoholforbrug eller -misbrug</a>, hvor helhedsbilledet kan v&aelig;re kompliceret af forhold, der p&aring;virker andre mark&oslash;rer</li>
    <li>CDT har lav sensitivitet is&aelig;r hos patienter med cirrose og kan derfor ikke anbefales som mark&oslash;r for alkoholforbrug hos patienter med leversygdom&nbsp;<a href=" " data-type="journal-reference" data-value="Arnts J, Vanlerberghe BTK, Roozen S, Crunelle CL, Masclee AAM, Olde-Damink SWM, Heeren RMA, van Nuijs A, Neels H, Nevens F, Verbeek J, Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review. Alcohol Clin Exp Res 2021;45: 25-37" data-value-piped="Arnts J, Vanlerberghe BTK, Roozen S, Crunelle CL, Masclee AAM, Olde-Damink SWM, Heeren RMA, van Nuijs A, Neels H, Nevens F, Verbeek J|Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review.|Alcohol Clin Exp Res|2021|45|25-37|33190239" data-url="reference-link" data-pubmedid="33190239" title="Arnts J, Vanlerberghe BTK, Roozen S, Crunelle CL, Masclee AAM, Olde-Damink SWM, Heeren RMA, van Nuijs A, Neels H, Nevens F, Verbeek J, Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review. Alcohol Clin Exp Res 2021;45: 25-37"><sup>1</sup></a></li>
</ul>
<h3>Alternative analyser/mark&oslash;rer</h3>
<ul>
    <li>En m&aring;ling af <a href="~/link.aspx?_id=4CC97C026E3E45DCA81505D8F09F2FE1&amp;_z=z">P-Gamma-Glutamyltransferase (GGT)</a>&nbsp;vil i mange tilf&aelig;lde v&aelig;re et brugbart alternativ i almen praksis, dog fx forudsat at patienten ikke har leversygdom med galdestase<a href=" " data-type="journal-reference" data-value="Helander A, Wielders J, Anton R, Arndt T, Bianchi V, Deenmamode J, Jeppsson JO, Whitfield JB, Weykamp C, Schellenberg F, International Federation of Clinical Chemistry and Laboratory Medicine Working Group on Standardisation of Carbohydrate-Deficient Transferrin (IFCC WG-CDT), Standardisation and use of the alcohol biomarker carbohydrate-deficient transferrin (CDT). Clin Chim Acta 2016;459: 19-24" data-value-piped="Helander A, Wielders J, Anton R, Arndt T, Bianchi V, Deenmamode J, Jeppsson JO, Whitfield JB, Weykamp C, Schellenberg F, International Federation of Clinical Chemistry and Laboratory Medicine Working Group on Standardisation of Carbohydrate-Deficient Transferrin (IFCC WG-CDT)|Standardisation and use of the alcohol biomarker carbohydrate-deficient transferrin (CDT).|Clin Chim Acta|2016|459|19-24|27221205" data-url="reference-link" data-pubmedid="27221205" title="Helander A, Wielders J, Anton R, Arndt T, Bianchi V, Deenmamode J, Jeppsson JO, Whitfield JB, Weykamp C, Schellenberg F, International Federation of Clinical Chemistry and Laboratory Medicine Working Group on Standardisation of Carbohydrate-Deficient Transferrin (IFCC WG-CDT), Standardisation and use of the alcohol biomarker carbohydrate-deficient transferrin (CDT). Clin Chim Acta 2016;459: 19-24"><sup>2</sup></a></li>
    <li>En simpel p&aring;visning af ethanol i ud&aring;ndingsluft (eller i en blodpr&oslash;ve) en formiddag p&aring; en almindelig hverdag vil ofte kunne signalere et alkoholmisbrug</li>
</ul>
<h2>Fortolkninger<a href=" " data-type="journal-reference" data-value="Helander A, Wielders J, Anton R, Arndt T, Bianchi V, Deenmamode J, Jeppsson JO, Whitfield JB, Weykamp C, Schellenberg F, International Federation of Clinical Chemistry and Laboratory Medicine Working Group on Standardisation of Carbohydrate-Deficient Transferrin (IFCC WG-CDT), Standardisation and use of the alcohol biomarker carbohydrate-deficient transferrin (CDT). Clin Chim Acta 2016;459: 19-24" data-value-piped="Helander A, Wielders J, Anton R, Arndt T, Bianchi V, Deenmamode J, Jeppsson JO, Whitfield JB, Weykamp C, Schellenberg F, International Federation of Clinical Chemistry and Laboratory Medicine Working Group on Standardisation of Carbohydrate-Deficient Transferrin (IFCC WG-CDT)|Standardisation and use of the alcohol biomarker carbohydrate-deficient transferrin (CDT).|Clin Chim Acta|2016|459|19-24|27221205" data-url="reference-link" data-pubmedid="27221205" title="Helander A, Wielders J, Anton R, Arndt T, Bianchi V, Deenmamode J, Jeppsson JO, Whitfield JB, Weykamp C, Schellenberg F, International Federation of Clinical Chemistry and Laboratory Medicine Working Group on Standardisation of Carbohydrate-Deficient Transferrin (IFCC WG-CDT), Standardisation and use of the alcohol biomarker carbohydrate-deficient transferrin (CDT). Clin Chim Acta 2016;459: 19-24"><sup>2</sup></a><sup>,</sup><a href=" " data-type="journal-reference" data-value="Morinaga M, Kon K, Uchiyama A, Fukada H, Fukuhara K, Yaginuma R, Nakadera E, Yamashina S, Ikejima K, Carbohydrate-deficient transferrin is a sensitive marker of alcohol consumption in fatty liver disease. Hepatol Int 2022;16: 348-358" data-value-piped="Morinaga M, Kon K, Uchiyama A, Fukada H, Fukuhara K, Yaginuma R, Nakadera E, Yamashina S, Ikejima K|Carbohydrate-deficient transferrin is a sensitive marker of alcohol consumption in fatty liver disease.|Hepatol Int|2022|16|348-358|35060066" data-url="reference-link" data-pubmedid="35060066" title="Morinaga M, Kon K, Uchiyama A, Fukada H, Fukuhara K, Yaginuma R, Nakadera E, Yamashina S, Ikejima K, Carbohydrate-deficient transferrin is a sensitive marker of alcohol consumption in fatty liver disease. Hepatol Int 2022;16: 348-358"><sup>3</sup></a><sup>,</sup><a href=" " data-type="journal-reference" data-value="Arnts J, Vanlerberghe BTK, Roozen S, Crunelle CL, Masclee AAM, Olde-Damink SWM, Heeren RMA, van Nuijs A, Neels H, Nevens F, Verbeek J, Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review. Alcohol Clin Exp Res 2021;45: 25-37" data-value-piped="Arnts J, Vanlerberghe BTK, Roozen S, Crunelle CL, Masclee AAM, Olde-Damink SWM, Heeren RMA, van Nuijs A, Neels H, Nevens F, Verbeek J|Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review.|Alcohol Clin Exp Res|2021|45|25-37|33190239" data-url="reference-link" data-pubmedid="33190239" title="Arnts J, Vanlerberghe BTK, Roozen S, Crunelle CL, Masclee AAM, Olde-Damink SWM, Heeren RMA, van Nuijs A, Neels H, Nevens F, Verbeek J, Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review. Alcohol Clin Exp Res 2021;45: 25-37"><sup>1</sup></a></h2>
<h3>Effekter af alkohol</h3>
<ul>
    <li>Forh&oslash;jede v&aelig;rdier (2-5 gange gr&aelig;nsev&aelig;rdien) ses s&aelig;dvanligvis efter indtagelse af mere end 5-7 genstande (60-85 gram alkohol) dagligt i mindst en uge</li>
    <li>Sensitiviteten er h&oslash;jst hos alkoholiserede patienter, mens andre patienter (og raske) godt kan have haft et midlertidigt h&oslash;jt alkoholforbrug i flere uger, uden at CDT bliver forh&oslash;jet. Et studie har vist, at CDT er bedre end GGT til at skelne mellem intet/let alkoholforbrug og et stort alkoholforbrug, med en cut-off p&aring; 2,08 % for "heavy drinkers" (mere end 60 gram dagligt)<a href=" " data-type="journal-reference" data-value="Morinaga M, Kon K, Uchiyama A, Fukada H, Fukuhara K, Yaginuma R, Nakadera E, Yamashina S, Ikejima K, Carbohydrate-deficient transferrin is a sensitive marker of alcohol consumption in fatty liver disease. Hepatol Int 2022;16: 348-358" data-value-piped="Morinaga M, Kon K, Uchiyama A, Fukada H, Fukuhara K, Yaginuma R, Nakadera E, Yamashina S, Ikejima K|Carbohydrate-deficient transferrin is a sensitive marker of alcohol consumption in fatty liver disease.|Hepatol Int|2022|16|348-358|35060066" data-url="reference-link" data-pubmedid="35060066" title="Morinaga M, Kon K, Uchiyama A, Fukada H, Fukuhara K, Yaginuma R, Nakadera E, Yamashina S, Ikejima K, Carbohydrate-deficient transferrin is a sensitive marker of alcohol consumption in fatty liver disease. Hepatol Int 2022;16: 348-358"><sup>3</sup></a>. Dette kan indg&aring; i en vurdering af, hvorvidt en leverp&aring;virkning er alkoholrelateret eller er&nbsp;<a href="https://www.sundhed.dk/sundhedsfaglig/laegehaandbogen/mave-tarm/tilstande-og-sygdomme/lever/nonalkoholisk-fedtleversygdom/">NAFLD</a>&nbsp;(Nonalkoholisk fedtleversygdom)</li>
    <li>CDT har en halveringstid p&aring; ca. 14 dage, dvs. at forh&oslash;jede v&aelig;rdier hos alkoholmisbrugere vil normaliseres i l&oslash;bet af 3 uger, hvis de f&oslash;lger en afv&aelig;nningsbehandling. Analysen kan derfor bruges til kontrol i s&aring;danne behandlingsforl&oslash;b</li>
    <li>Antabus har ingen selvst&aelig;ndig indflydelse p&aring; m&aring;lev&aelig;rdierne af CDT</li>
</ul>
<h3>Andre tilstande</h3>
<ul>
    <li>Forh&oslash;jede v&aelig;rdier ses ogs&aring; ved ikke-alkoholisk leversygdom, fx cirrose efter kronisk aktiv hepatit, ved p<a href="~/link.aspx?_id=C79829A552DC4EC2A96AF23B5E67912E&amp;_z=z">rim&aelig;r bili&aelig;r cirrose</a>&nbsp;og ved&nbsp;<a href="~/link.aspx?_id=D558F676894340AE86329BC38E2418FB&amp;_z=z">hepatocellul&aelig;rt carcinom</a></li>
    <li>Meget h&oslash;je v&aelig;rdier kan ses ved det sj&aelig;ldne heredit&aelig;re carbohydrat-deficient glykoprotein syndrom, og hos nogle patienter med cystisk fibrose</li>
    <li>Let forh&oslash;jede v&aelig;rdier kan ses ved jernmangel, under graviditet og ved behandling med &oslash;strogener, hos patienter med demens, ved misbrug af organiske opl&oslash;sningsmidler ("snifning"), samt ved&nbsp;<a href="~/link.aspx?_id=3878D118D7204DA7ADC2DDA60921DA71&amp;_z=z">colorektalt carcinom</a>&nbsp;og ved ubehandlet galaktos&aelig;mi</li>
    <li>CDT er lavere hos personer med h&oslash;jt BMI&nbsp;</li>
</ul>
<h2>Generelt om biokemiske mark&oslash;rer for h&oslash;jt alkoholforbrug<a href=" " data-type="journal-reference" data-value="Arnts J, Vanlerberghe BTK, Roozen S, Crunelle CL, Masclee AAM, Olde-Damink SWM, Heeren RMA, van Nuijs A, Neels H, Nevens F, Verbeek J, Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review. Alcohol Clin Exp Res 2021;45: 25-37" data-value-piped="Arnts J, Vanlerberghe BTK, Roozen S, Crunelle CL, Masclee AAM, Olde-Damink SWM, Heeren RMA, van Nuijs A, Neels H, Nevens F, Verbeek J|Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review.|Alcohol Clin Exp Res|2021|45|25-37|33190239" data-url="reference-link" data-pubmedid="33190239" title="Arnts J, Vanlerberghe BTK, Roozen S, Crunelle CL, Masclee AAM, Olde-Damink SWM, Heeren RMA, van Nuijs A, Neels H, Nevens F, Verbeek J, Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review. Alcohol Clin Exp Res 2021;45: 25-37"><sup>1</sup></a></h2>
<ul>
    <li>Der findes ingen enkelte eller f&aring; biokemiske analyser, der kan anvendes til sikker p&aring;visning af et h&oslash;jt alkoholforbrug, eller til at udelukke det<a href=" " data-type="journal-reference" data-value="Morinaga M, Kon K, Uchiyama A, Fukada H, Fukuhara K, Yaginuma R, Nakadera E, Yamashina S, Ikejima K, Carbohydrate-deficient transferrin is a sensitive marker of alcohol consumption in fatty liver disease. Hepatol Int 2022;16: 348-358" data-value-piped="Morinaga M, Kon K, Uchiyama A, Fukada H, Fukuhara K, Yaginuma R, Nakadera E, Yamashina S, Ikejima K|Carbohydrate-deficient transferrin is a sensitive marker of alcohol consumption in fatty liver disease.|Hepatol Int|2022|16|348-358|35060066" data-url="reference-link" data-pubmedid="35060066" title="Morinaga M, Kon K, Uchiyama A, Fukada H, Fukuhara K, Yaginuma R, Nakadera E, Yamashina S, Ikejima K, Carbohydrate-deficient transferrin is a sensitive marker of alcohol consumption in fatty liver disease. Hepatol Int 2022;16: 348-358"><sup>3</sup></a></li>
    <li>Det skyldes is&aelig;r at:</li>
    <ul>
        <li>Der er store interindividuelle forskelle i de biologiske effekter af et givet alkoholforbrug</li>
        <li>De biokemiske effekter af alkoholindtagelse er afh&aelig;ngigt af forbrugsm&oslash;nsteret</li>
        <li>Der er mange andre tilstande og p&aring;virkninger, som har en effekt p&aring; v&aelig;rdierne af de biokemiske analyser, herunder is&aelig;r leversygdomme (uanset &aelig;tiologien)</li>
    </ul>
    <li>Udover forh&oslash;jede v&aelig;rdier af CDT og GGT, eller p&aring;visning af etanol i ud&aring;ndingsluft (eller i en blodpr&oslash;ve) en formiddag p&aring; en almindelig hverdag, kan man ofte, men langt fra altid, ogs&aring; se:</li>
    <ul>
        <li>Et h&oslash;jt&nbsp;<a href="~/link.aspx?_id=E8331EE44129490180542CEF5EA275A5&amp;_z=z">erytrocyt-middelcellevolumen (MCV)</a></li>
        <li>Forh&oslash;jet&nbsp;<a href="~/link.aspx?_id=CAEF0A174B334B75805EB18D6A266EE1&amp;_z=z">alanin-aminotransferase (ALAT)</a></li>
        <li>Forh&oslash;jet&nbsp;<a href="~/link.aspx?_id=1EC226C28A704C08985C187EE58092BF&amp;_z=z">aspartat-aminotranferase (ASAT)</a></li>
        <li>H&oslash;jt&nbsp;<a href="~/link.aspx?_id=01AD84851E234EC8A2AFA356C41CEA75&amp;_z=z">HDL-kolesterol</a></li>
        <li>Forh&oslash;jet&nbsp;<a href="~/link.aspx?_id=C327E3DB5B774314AA0141EE7598E95A&amp;_z=z">triglycerid</a></li>
        <li>H&oslash;jt immunoglobulin A</li>
        <li>Forh&oslash;jet&nbsp;<a href="~/link.aspx?_id=811A5894F14247A09284E6F02FADF655&amp;_z=z">urat</a></li>
    </ul>
    <li>Der findes andre biokemiske mark&oslash;rer<a href=" " data-type="journal-reference" data-value="Arnts J, Vanlerberghe BTK, Roozen S, Crunelle CL, Masclee AAM, Olde-Damink SWM, Heeren RMA, van Nuijs A, Neels H, Nevens F, Verbeek J, Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review. Alcohol Clin Exp Res 2021;45: 25-37" data-value-piped="Arnts J, Vanlerberghe BTK, Roozen S, Crunelle CL, Masclee AAM, Olde-Damink SWM, Heeren RMA, van Nuijs A, Neels H, Nevens F, Verbeek J|Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review.|Alcohol Clin Exp Res|2021|45|25-37|33190239" data-url="reference-link" data-pubmedid="33190239" title="Arnts J, Vanlerberghe BTK, Roozen S, Crunelle CL, Masclee AAM, Olde-Damink SWM, Heeren RMA, van Nuijs A, Neels H, Nevens F, Verbeek J, Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review. Alcohol Clin Exp Res 2021;45: 25-37"><sup>1</sup></a><sup>,</sup><a href=" " data-type="journal-reference" data-value="Arnts J, Vanlerberghe BTK, Roozen S, Crunelle CL, Masclee AAM, Olde-Damink SWM, Heeren RMA, van Nuijs A, Neels H, Nevens F, Verbeek J, Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review. Alcohol Clin Exp Res 2021;45: 25-37" data-value-piped="Arnts J, Vanlerberghe BTK, Roozen S, Crunelle CL, Masclee AAM, Olde-Damink SWM, Heeren RMA, van Nuijs A, Neels H, Nevens F, Verbeek J|Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review.|Alcohol Clin Exp Res|2021|45|25-37|33190239" data-url="reference-link" data-pubmedid="33190239" title="Arnts J, Vanlerberghe BTK, Roozen S, Crunelle CL, Masclee AAM, Olde-Damink SWM, Heeren RMA, van Nuijs A, Neels H, Nevens F, Verbeek J, Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review. Alcohol Clin Exp Res 2021;45: 25-37"><sup>1</sup></a>, som p.t. dog ikke anvendes i Danmark</li>
</ul>
<h2>Fejlkilder&nbsp;(og kilder til normal variation)</h2>
<ul>
    <li>Forurening af serumpr&oslash;ven med mikroorganismer skal undg&aring;s, da mange producerer neuramidase og derfor kan give falsk forh&oslash;jede v&aelig;rdier af CDT</li>
    <li>Hvis CDT bestemmes med andre metoder end den nedenn&aelig;vnte, kan meget h&oslash;je eller lave v&aelig;rdier af&nbsp;<a href="~/link.aspx?_id=5E75EFD21BC945608B6B111075CCBCD4&amp;_z=z">P-Transferrin</a>&nbsp;give forkerte resultater, ligesom der ogs&aring; kan v&aelig;re problemer ved forekomsten af visse genetiske varianter af proteinet</li>
    <li>H&oslash;jt BMI kan give falsk for lave resultater</li>
    <li>Cirrose kan p&aring;virke den kromatografiske adskillelse af transferrin-isoformerne, hvilket forringer den anvendelighed hos disse patienter&nbsp;<a href=" " data-type="journal-reference" data-value="Arnts J, Vanlerberghe BTK, Roozen S, Crunelle CL, Masclee AAM, Olde-Damink SWM, Heeren RMA, van Nuijs A, Neels H, Nevens F, Verbeek J, Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review. Alcohol Clin Exp Res 2021;45: 25-37" data-value-piped="Arnts J, Vanlerberghe BTK, Roozen S, Crunelle CL, Masclee AAM, Olde-Damink SWM, Heeren RMA, van Nuijs A, Neels H, Nevens F, Verbeek J|Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review.|Alcohol Clin Exp Res|2021|45|25-37|33190239" data-url="reference-link" data-pubmedid="33190239" title="Arnts J, Vanlerberghe BTK, Roozen S, Crunelle CL, Masclee AAM, Olde-Damink SWM, Heeren RMA, van Nuijs A, Neels H, Nevens F, Verbeek J, Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review. Alcohol Clin Exp Res 2021;45: 25-37"><sup>1</sup></a></li>
</ul>
<h2>Biokemisk baggrund&nbsp;</h2>
<ul>
    <li>Transferrin er et jernbindende protein, som i plasma findes i forskellige isoformer med et varierende antal k&aelig;der af sialsyre (et kulhydrat; arbohydrat)</li>
    <li>Den almindeligste isoform har 4 k&aelig;der (tetrasialo-transferrin), mens isoformer med 5 eller 3 k&aelig;der findes i mindre m&aelig;ngder, og isoformer med 2, 1 eller 0 k&aelig;der normalt kun findes i sm&aring; m&aelig;ngder</li>
    <li>Hos personer med et stort forbrug af alkohol &oslash;ges m&aelig;ngden af disse tre kulhydratfattige isoformer (disialo-, monosialo- og asialo-transferrin), og is&aelig;r disialo-transferrin</li>
</ul>
<h3>M&aring;lemetode</h3>
<ul>
    <li>Metoden bestemmer fraktionen af<a href="https://www.analysefortegnelsen.dk/AnalyselisteZoom.asp?Type=Andre&amp;Lok=AUH&amp;ID=NPU57406"> disialo-transferrin</a> med brug af kapillarelektroforese</li>
    <li>Der findes en international referencemetode for analysen, som betyder, at analyseresultater er mere sammenlignelige fra laboratorium til laboratorium, end det tidligere var tilf&aelig;ldet</li>
    <li>Den angivne gr&aelig;nsev&aelig;rdi nedenfor g&aelig;lder for m&aring;linger udf&oslash;rt med den anbefalede metode</li>
    <li>Cirrose kan p&aring;virke den kromatografiske adskillelse af transferrin-isoformerne, hvilket forringer den anvendelighed hos disse patienter&nbsp;<a href=" " data-type="journal-reference" data-value="Arnts J, Vanlerberghe BTK, Roozen S, Crunelle CL, Masclee AAM, Olde-Damink SWM, Heeren RMA, van Nuijs A, Neels H, Nevens F, Verbeek J, Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review. Alcohol Clin Exp Res 2021;45: 25-37" data-value-piped="Arnts J, Vanlerberghe BTK, Roozen S, Crunelle CL, Masclee AAM, Olde-Damink SWM, Heeren RMA, van Nuijs A, Neels H, Nevens F, Verbeek J|Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review.|Alcohol Clin Exp Res|2021|45|25-37|33190239" data-url="reference-link" data-pubmedid="33190239" title="Arnts J, Vanlerberghe BTK, Roozen S, Crunelle CL, Masclee AAM, Olde-Damink SWM, Heeren RMA, van Nuijs A, Neels H, Nevens F, Verbeek J, Diagnostic Accuracy of Biomarkers of Alcohol Use in Patients With Liver Disease: A Systematic Review. Alcohol Clin Exp Res 2021;45: 25-37"><sup>1</sup></a></li>
</ul>
<h2>Pr&oslash;vetagning</h2>
<ul>
    <li>Veneblodpr&oslash;ve i et r&oslash;r uden antikoagulans (t&oslash;rglas)</li>
    <li>Serum skal afpipetteres indenfor 4 timer og er kun holdbart 1-2 d&oslash;gn ved stuetemperatur. Kan sendes til laboratoriet med almindelig post</li>
    <li>Nedfrosset serum er stabilt i flere &aring;r</li>
</ul>
<h2>Referenceintervaller<sup></sup></h2>
<ul>
    <li>Under 0,020, dvs. mindre end 2,00 %</li>
</ul>
<h2>Patientinformation</h2>
<ul>
    <li><a href="~/link.aspx?_id=22882A555FEA491E8ADD78EF5E8E8C96&amp;_z=z">Kulhydratfattigt transferrin</a></li>
</ul>
<h2>NPU-koder og -navne</h2>
<ul>
    <li>NPU19601</li>
</ul>
<h2>Navne</h2>
<ul>
    <li>Langt navn
    <ul>
        <li>Transferrin(P)&mdash;Disialotransferrin; stoffr. = ?</li>
    </ul>
    </li>
    <li>Kort navn
    <ul>
        <li>Disialotransferrin [CDT];Transf.(P)</li>
    </ul>
    </li>
</ul>]]></HtmlField>
      <HtmlField Name="Resume"><![CDATA[<h2>Resum&eacute;</h2>
<ul>
    <li>Disialo-transferrin (kulhydratfattigt transferrin) (CDT) i plasma har lav til moderat sensitivitet (40-79 %) og h&oslash;jere specificitet (57-99 %) som mark&oslash;r for et h&oslash;jt alkoholforbrug de seneste 1- 2 uger</li>
    <li>Sammenh&aelig;ngen mellem alkoholindtag og CDT-niveaet er mere udtalt end for GGT&nbsp;</li>
    <li>Analysen anvendes ikke meget, fordi der til brug i de fleste kliniske sammenh&aelig;nge findes billigere alternativer</li>
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      <DateTimeField Name="RevisedDate">2024-02-20T11:33:00</DateTimeField>
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