jern (LH Indholdsside)

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  <Item Id="{84F24B5E-CB9C-48AE-9BC4-A1DCB7ED5C3F}" Name="jern" Type="LHContentPage" ParentProviderId="sundheddkcms" ParentItemId="{954990FB-BCA1-4322-A1A9-62D3FD4B2E07}" SortOrder="6400" PublishDate="2010-11-08T12:28:00" DeleteDate="2999-12-31T00:00:00" PotItemType="">
    <Content>
      <HtmlField Name="PageContent"><![CDATA[<h2>Definition</h2>
<ul>
    <li>Den totale plasmakoncentration af jern, m&aring;lt som mikromol per liter (&micro;mol/L)</li>
</ul>
<h2>Synonymer</h2>
<ul>
    <li>Plasmajern; P-Jern; Serumjern; S-Jern; Fe</li>
</ul>
<h2>Indikationer</h2>
<ul>
    <li>P-Jern er en af flere analyser til vurdering af jern-status. Da&nbsp;jern&nbsp;oms&aelig;ttes meget hurtigt,&nbsp;er koncentrationen af P-Jern&nbsp;et &oslash;jebliksbillede, og&nbsp;b&oslash;r&nbsp;altid&nbsp;suppleres med andre analyser fx h&aelig;moglobin,&nbsp;ferritin,&nbsp;transferrin (s&aring; jernm&aelig;tning kan beregnes), MCV og evt. MCH<a href="/EditorPage.aspx?da=core&amp;id=%7B84F24B5E-CB9C-48AE-9BC4-A1DCB7ED5C3F%7D&amp;ed=FIELD1066273456&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H1066273718&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Pfeiffer CM, Looker AC, Laboratory methodologies for indicators of iron status: strengths, limitations, and analytical challenges. Am J Clin Nutr 2017;106: 1606S-1614S" data-value-piped="Pfeiffer CM, Looker AC|Laboratory methodologies for indicators of iron status: strengths, limitations, and analytical challenges.|Am J Clin Nutr|2017|106|1606S-1614S|29070545" data-url="reference-link" data-pubmedid="29070545" title="Pfeiffer CM, Looker AC, Laboratory methodologies for indicators of iron status: strengths, limitations, and analytical challenges. Am J Clin Nutr 2017;106: 1606S-1614S"><sup>1</sup></a></li>
    <li>Udredning af&nbsp;<a href="~/link.aspx?_id=679CED2A382C4F259AEFCC1C7340FC92&amp;_z=z">anaemier</a>&nbsp;for at diagnosticere&nbsp;<a href="~/link.aspx?_id=3E0BE5773DAD45AEBB1BD38356541539&amp;_z=z">jernmangelanaemi</a></li>
    <li>Mistanke om&nbsp;<a href="~/link.aspx?_id=DCC02894FB4B47298BC6094780800A34&amp;_z=z">h&aelig;mokromatose</a></li>
    <li>Mistanke om overdosering med jern, eller&nbsp;<a href="~/link.aspx?_id=F1B62A9F8E61438094BE2D74AF095985&amp;_z=z">jernforgiftning</a></li>
    <li>Forud for jernbehandling af patienter med hjerteinsufficiens og monitorering&nbsp; af jernbehandling&nbsp;</li>
</ul>
<h3>Brug af andre blodpr&oslash;ver</h3>
<ul>
    <li>P-Jern skal bestilles sammen med h&aelig;moglobin, ferritin, CRP,&nbsp;<a href="~/link.aspx?_id=5E75EFD21BC945608B6B111075CCBCD4&amp;_z=z">transferrin</a>&nbsp;(eller total jernbindingkapacitet; TIBC, eller Transferrin-m&aelig;tning; TSAT; Transferrinjern; jernm&aelig;tning)
    <ul>
        <li>Beregningen af transferrin-m&aelig;tning = P-Jern / 2 x P-transferrin %</li>
    </ul>
    </li>
    <li>De fleste laboratorier tilbyder en dynamisk udredning for an&aelig;mi, som ikke indeholder m&aring;ling af jern</li>
    <li>Ved mistanke om jernmangel b&oslash;r der altid bestilles&nbsp;<a href="~/link.aspx?_id=B347096E158D41C58AFFF43E52829778&amp;_z=z">ferritin</a>&nbsp;(og CRP), da jern&nbsp;og transferrin koncentrationer ikke altid kan afsl&oslash;re jernmangel</li>
    <li>Jernmangel kan ikke udelukkes ved&nbsp;normalt eller forh&oslash;jet ferritin niveau, da&nbsp;ferritin stiger i forbindelse med&nbsp;inflammatoriske tilstande. Derfor&nbsp;kan det&nbsp;anbefales at supplere med&nbsp;<a href="~/link.aspx?_id=F10DDAF5C6D84D01874EFE1D27450A03&amp;_z=z">C-reaktivt protein (CRP)</a>&nbsp;</li>
    <li>&AElig;gte jernmangel, i mods&aelig;tning til funktionel jernmangel, ses ogs&aring; hyppigt i kombination med an&aelig;mi som f&oslash;lge af kronisk/inflammatorisk sygdom<a href=" " data-type="journal-reference" data-value="Weiss G, Ganz T, Goodnough LT, Anemia of inflammation. Blood 2019;133: 40-50" data-value-piped="Weiss G, Ganz T, Goodnough LT|Anemia of inflammation.|Blood|2019|133|40-50|30401705" data-url="reference-link" data-pubmedid="30401705" title="Weiss G, Ganz T, Goodnough LT, Anemia of inflammation. Blood 2019;133: 40-50"><sup>2</sup></a>&nbsp;</li>
</ul>
<h2>Fortolkninger&nbsp;</h2>
<ul>
    <li>Resultaterne skal tolkes sammen med&nbsp;<a href="~/link.aspx?_id=5E75EFD21BC945608B6B111075CCBCD4&amp;_z=z">transferrin</a>/transferrinm&aelig;tning.&nbsp;Hvis der er mistanke om jernmangelan&aelig;mi, skal P-Jern altid tolkes&nbsp;sammen med&nbsp;<a href="~/link.aspx?_id=B347096E158D41C58AFFF43E52829778&amp;_z=z">ferritin</a>&nbsp;og <a href="~/link.aspx?_id=F10DDAF5C6D84D01874EFE1D27450A03&amp;_z=z">CRP</a></li>
    <li>Der kan ved kroniske sygdomme v&aelig;re funktionel jernmangel med lavt&nbsp;jernniveau i blodbanen og ophobning af jern i cellerne. Det skyldes et h&oslash;jt niveau af proteinet hepcidin, som blokerer jern-kanalerne i cellemembranen. Se ogs&aring; <a href="https://www.sundhed.dk/sundhedsfaglig/laegehaandbogen/blod/tilstande-og-sygdomme/anaemier/anaemi-ved-kronisk-sygdom/">an&aelig;mi ved kronisk sygdom</a></li>
</ul>
<h3>Forh&oslash;jede v&aelig;rdier</h3>
<ul>
    <li>Forh&oslash;jede v&aelig;rdier med samtidigt forh&oslash;jet&nbsp;<a href="~/link.aspx?_id=5E75EFD21BC945608B6B111075CCBCD4&amp;_z=z">transferrinm&aelig;tning&nbsp;</a>kan ses ved heredit&aelig;r h&aelig;mokromatose, h&aelig;mosiderose, efter jernterapi og ved akut forgiftning</li>
    <li>Ses ogs&aring; ved&nbsp;<a href="~/link.aspx?_id=1A0F3F20CA1848F595B1118E358DED41&amp;_z=z">h&aelig;molytiske an&aelig;mier</a>, sideroblastan&aelig;mi, akutte leuk&aelig;mier, hepatitis og&nbsp;<a href="~/link.aspx?_id=E4952F1176A64A1F91299626791C4A3F&amp;_z=z">levercirrose</a></li>
    <li>Ved intoksikation tyder v&aelig;rdier over 90 &micro;mol/l p&aring; en alvorlig forgiftning, men en v&aelig;rdi b&oslash;r altid vurderes i relation til tidspunktet for indtagelsen af pr&aelig;paratet og klinikken. Optimalt tages pr&oslash;ven 4 timer efter indtagelse, gentages 2 - 4 timer efter s&aring;fremt indtagelsen er sket med depottabletter</li>
</ul>
<h3>Lave v&aelig;rdier</h3>
<ul>
    <li>Ses typisk ved jernmangel, men ogs&aring; meget hyppigt ved kroniske sygdomme, is&aelig;r inflammatoriske tilstande
    <ul>
        <li> P-Jern kan ikke bruges at skelne mellem&nbsp;<a href="~/link.aspx?_id=3E0BE5773DAD45AEBB1BD38356541539&amp;_z=z">jernmangelan&aelig;mi</a>&nbsp;og&nbsp;<a href="~/link.aspx?_id=F67EF4EFDACF487886702A9FA5D0F25A&amp;_z=z">an&aelig;mi ved kronisk sygdom</a></li>
        <li>Ved mistanke om jernmangelan&aelig;mi er&nbsp;<a href="~/link.aspx?_id=B347096E158D41C58AFFF43E52829778&amp;_z=z">ferritin</a>&nbsp;bedre. </li>
        <li>Enkelte laboratorier kan analysere&nbsp;hepcidin niveauet.&nbsp;Et h&oslash;jt&nbsp;hepcidin-niveau og samtidig lavt P-Jern tyder p&aring; en funktionel jernmangeltilstand ("reaktiv an&aelig;mi")</li>
    </ul>
    </li>
    <li>Lave v&aelig;rdier med samtidig lave eller normale v&aelig;rdier af transferrin kan ses ved akutte og kroniske infektioner, ved malnutrition, efter st&oslash;rre operationer, under remission af pernici&oslash;s an&aelig;mi, ved nefrotisk syndrom og en lang r&aelig;kke cancere, s&aring;vel solide tumorer som maligne h&aelig;matologiske sygdomme. Jernmanglen kan her v&aelig;re til stede f&oslash;r behandlingsstart og er ikke altid kombineret med an&aelig;mi&nbsp;<a href=" " data-type="journal-reference" data-value="Ludwig H, Müldür E, Endler G, Hübl W, Prevalence of iron deficiency across different tumors and its association with poor performance status, disease status and anemia. Ann Oncol 2013;24: 1886-1892" data-value-piped="Ludwig H, Müldür E, Endler G, Hübl W|Prevalence of iron deficiency across different tumors and its association with poor performance status, disease status and anemia.|Ann Oncol|2013|24|1886-1892|23567147" data-url="reference-link" data-pubmedid="23567147" title="Ludwig H, Müldür E, Endler G, Hübl W, Prevalence of iron deficiency across different tumors and its association with poor performance status, disease status and anemia. Ann Oncol 2013;24: 1886-1892"><sup>3</sup></a>&nbsp;</li>
</ul>
<h2>Fejlkilder (og kilder til normal variation)</h2>
<ul>
    <li>Jern har en stor d&oslash;gnvariation med en forskel p&aring; op til 4&nbsp;&micro;mol/L fra h&oslash;jest (ca. kl. 12) til lavest (ca. kl. 24)<a href=" " data-type="journal-reference" data-value="Sennels HP, Jørgensen HL, Fahrenkrug J, [Diagnostic measurements and diurnal rhythms]. Ugeskr Laeger 2018;180: " data-value-piped="Sennels HP, Jørgensen HL, Fahrenkrug J|[Diagnostic measurements and diurnal rhythms].|Ugeskr Laeger|2018|180||30348257" data-url="reference-link" data-pubmedid="30348257" title="Sennels HP, Jørgensen HL, Fahrenkrug J, [Diagnostic measurements and diurnal rhythms]. Ugeskr Laeger 2018;180: "><sup>4</sup></a></li>
    <li>Jernniveau er p&aring;virkeligt af f&oslash;dens jernindhold</li>
    <li>
    Transferrin-m&aelig;tning kan v&aelig;re lav uden samtidig jernmangel. Dette kan ses ved h&oslash;jt niveau af transferrin som f&oslash;lge af &oslash;strogenp&aring;virkning fx. P-piller og graviditet
    </li>
</ul>
<h2>Fysiologi og biokemi</h2>
<ul>
    <li>
    Blodets jernindhold oms&aelig;ttes flere gange i d&oslash;gnet og koncentrationen af P-Jern er et &oslash;jebliksbillede. Oms&aelig;tningen reguleres af erytrocyt-produktionen i knoglemarven
    </li>
    <li>Stor d&oslash;gnvariation, lavest om aftenen</li>
    <li>
    Jern er bundet til transferrin i blodbanen (kan binde to jern-atomer) og findes ikke frit i blodet. Frit jern er toksisk og har en &aelig;tsende effekt
    </li>
    <li>
    Om jernoms&aelig;tningen se&nbsp;<a href="~/link.aspx?_id=F50735C9D26F4138BBD52D97AF036F1D&amp;_z=z">denne figur</a>
    </li>
    <li>
    <a href="~/link.aspx?_id=F50735C9D26F4138BBD52D97AF036F1D&amp;_z=z"></a>Jern transporteres til knoglemarv og det reticuloendotheliale system, hvorfra det ved behov kan mobiliseres&nbsp;
    </li>
    <li>
    &Oslash;get jern-indtag menes at v&aelig;re associeret med risiko for cancer, fx mammae-, Colon-, Colorectal-, lever- og lunge-cancer<a href="EditorPage.aspx?da=core&amp;id=%7B84F24B5E-CB9C-48AE-9BC4-A1DCB7ED5C3F%7D&amp;ed=FIELD28217959156&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H28217959215&amp;us=sitecore%5Cneho&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Sanagoo A, Kiani F, Saei Gharenaz M, Sayehmiri F, Koohi F, Jouybari L, Dousti M, A systematic review and meta-analysis on the association of serum and tumor tissue iron and risk of breast cancer. Caspian J Intern Med 2020;11: 1-11" data-value-piped="Sanagoo A, Kiani F, Saei Gharenaz M, Sayehmiri F, Koohi F, Jouybari L, Dousti M|A systematic review and meta-analysis on the association of serum and tumor tissue iron and risk of breast cancer.|Caspian J Intern Med|2020|11|1-11|32042380" data-url="reference-link" data-pubmedid="32042380" title="Sanagoo A, Kiani F, Saei Gharenaz M, Sayehmiri F, Koohi F, Jouybari L, Dousti M, A systematic review and meta-analysis on the association of serum and tumor tissue iron and risk of breast cancer. Caspian J Intern Med 2020;11: 1-11"><sup>5</sup></a><sup>,</sup><a href="EditorPage.aspx?da=core&amp;id=%7B84F24B5E-CB9C-48AE-9BC4-A1DCB7ED5C3F%7D&amp;ed=FIELD28217955628&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H28217955775&amp;us=sitecore%5Cneho&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Chang VC, Cotterchio M, Khoo E, Iron intake, body iron status, and risk of breast cancer: a systematic review and meta-analysis. BMC Cancer 2019;19: 543" data-value-piped="Chang VC, Cotterchio M, Khoo E|Iron intake, body iron status, and risk of breast cancer: a systematic review and meta-analysis.|BMC Cancer|2019|19|543|31170936" data-url="reference-link" data-pubmedid="31170936" title="Chang VC, Cotterchio M, Khoo E, Iron intake, body iron status, and risk of breast cancer: a systematic review and meta-analysis. BMC Cancer 2019;19: 543"><sup>6</sup></a><sup>,</sup><a href="EditorPage.aspx?da=core&amp;id=%7B84F24B5E-CB9C-48AE-9BC4-A1DCB7ED5C3F%7D&amp;ed=FIELD28217959156&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H28217959215&amp;us=sitecore%5Cneho&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Fonseca-Nunes A, Jakszyn P, Agudo A, Iron and cancer risk--a systematic review and meta-analysis of the epidemiological evidence. Cancer Epidemiol Biomarkers Prev 2014;23: 12-31" data-value-piped="Fonseca-Nunes A, Jakszyn P, Agudo A|Iron and cancer risk--a systematic review and meta-analysis of the epidemiological evidence.|Cancer Epidemiol Biomarkers Prev|2014|23|12-31|24243555" data-url="reference-link" data-pubmedid="24243555" title="Fonseca-Nunes A, Jakszyn P, Agudo A, Iron and cancer risk--a systematic review and meta-analysis of the epidemiological evidence. Cancer Epidemiol Biomarkers Prev 2014;23: 12-31"><sup>7</sup></a><sup>,</sup><a href="EditorPage.aspx?da=core&amp;id=%7B84F24B5E-CB9C-48AE-9BC4-A1DCB7ED5C3F%7D&amp;ed=FIELD28217959156&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H28217959215&amp;us=sitecore%5Cneho&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Tran KT, Coleman HG, McCain RS, Cardwell CR, Serum Biomarkers of Iron Status and Risk of Primary Liver Cancer: A Systematic Review and Meta-Analysis. Nutr Cancer 2019;71: 1365-1373" data-value-piped="Tran KT, Coleman HG, McCain RS, Cardwell CR|Serum Biomarkers of Iron Status and Risk of Primary Liver Cancer: A Systematic Review and Meta-Analysis.|Nutr Cancer|2019|71|1365-1373|31044614" data-url="reference-link" data-pubmedid="31044614" title="Tran KT, Coleman HG, McCain RS, Cardwell CR, Serum Biomarkers of Iron Status and Risk of Primary Liver Cancer: A Systematic Review and Meta-Analysis. Nutr Cancer 2019;71: 1365-1373"><sup>8</sup></a>&nbsp;
    </li>
</ul>
<h2>Pr&oslash;vetagning</h2>
<h3>Patientforberedelse</h3>
<ul>
    <li>Jern b&oslash;r tages om morgenen, da referenceintervallet er bestemt p&aring; pr&oslash;ver, taget om morgenen&nbsp;</li>
    <li>Parental jernbehandling giver kraftigt for&oslash;gede v&aelig;rdier af P-Jern og transferrinm&aelig;tning op til 6 uger efter en injektion</li>
</ul>
<h3>Pr&oslash;ve</h3>
<ul>
    <li>Veneblodpr&oslash;ve</li>
    <li>Pr&oslash;vetagningsr&oslash;r med heparin (til plasma) eller r&oslash;r uden antikoagulans (til serum)</li>
    <li>Afpipetteret plasma eller serum er holdbart i 1 uge ved stuetemperatur og 3 uger ved 4<sup>o</sup>C</li>
</ul>
<h2>Referenceintervaller</h2>
<ul>
    <li>For b&oslash;rn er der&nbsp;forskelle i de angivne intervaller fra laboratorium til laboratorium</li>
    <li>Voksne over 18 &aring;r: 9-34 &micro;mol/L</li>
    <li>B&oslash;rn og unge
    <ul>
        <li>Ved f&oslash;dslen: 18 - 45 &micro;mol/L</li>
        <li>0 - 4 uger: 11 - 36 &micro;mol/L</li>
        <li>5 - 8 uger: 10 - 31 &micro;mol/L</li>
        <li>2 - 6 m&aring;neder: 3 - 29 &micro;mol/L</li>
        <li>7 - 12 m&aring;neder: 5 - 28 &micro;mol/L</li>
        <li>1 - 12 &aring;r: 5 - 20 &micro;mol/L</li>
        <li>13 - 18 &aring;r: 10-25 &micro;mol/L</li>
    </ul>
    </li>
    <li>Gravide
    <ul>
        <li>3.-12. graviditetsuge: 9 - 34 &micro;mol/L</li>
        <li>3.-42. graviditetsuge: 7 - 35 &micro;mol/L</li>
        <li>Partus (P), P+1 dag: 4 - 28 &micro;mol/L</li>
        <li>P+2 dage: 4 - 21 &micro;mol/L</li>
    </ul>
    </li>
</ul>
<h2>Patientinformation</h2>
<ul>
    <li><a href="~/link.aspx?_id=CB378B64CCE34F169DAB93A0571ACC9B&amp;_z=z">Jern</a></li>
</ul>
<h2>NPU-koder og -navne</h2>
<ul>
    <li>NPU02508</li>
</ul>
<h3>Navne</h3>
<ul>
    <li><strong>Kort helterm</strong>
    <ul>
        <li>P&mdash;Jern; stofk. = ? &micro;mol/L</li>
    </ul>
    </li>
    <li><strong>Brugsnavn</strong>
    <ul>
        <li>Jern;P</li>
    </ul>
    </li>
</ul>
<h2>Opf&oslash;lgning</h2>
<ul>
    <li>Afh&aelig;nger af omst&aelig;ndighederne</li>
</ul>]]></HtmlField>
      <HtmlField Name="Resume"><![CDATA[<h2>Resum&eacute;</h2>
<ul>
    <li>M&aring;ling af jern er almindelig klinisk praksis i forbindelse med an&aelig;miudredning</li>
    <li>P-Jern skal bestilles sammen med h&aelig;moglobin, ferritin, CRP,&nbsp;<a href="~/link.aspx?_id=5E75EFD21BC945608B6B111075CCBCD4&amp;_z=z">transferrin</a>&nbsp;eller transferrin-m&aelig;tning</li>
    <li>Indikation er an&aelig;mi, mistanke om&nbsp;<a href="~/link.aspx?_id=3E0BE5773DAD45AEBB1BD38356541539&amp;_z=z">jernmangelan&aelig;mi</a>&nbsp;eller&nbsp;<a href="~/link.aspx?_id=DCC02894FB4B47298BC6094780800A34&amp;_z=z">h&aelig;mokromatose</a>&nbsp;(m&aring;lt som transferrin-jernm&aelig;tning) samt mistanke om jernforgiftning&nbsp;<a href="%20" title="Lyngbye J, Kjær A, Ladefoged SA, Nissen PH. . Lyngbyes laboratoriemedicin. 2. udg.. København: Nyt Nordisk Forlag Arnold Busck A/S; 2010" data-url="reference-link" data-value-piped="Lyngbye J, Kjær A, Ladefoged SA, Nissen PH. |Lyngbyes laboratoriemedicin. 2. udg.|København|Nyt Nordisk Forlag Arnold Busck A/S|2010" data-value="Lyngbye J, Kjær A, Ladefoged SA, Nissen PH. . Lyngbyes laboratoriemedicin. 2. udg.. København: Nyt Nordisk Forlag Arnold Busck A/S; 2010" data-type="book-reference"><sup>1</sup></a>. Gastrointestinal bl&oslash;dning b&oslash;r s&aring;ledes altid udl&oslash;se m&aring;ling af jern sammen med h&aelig;moglobin,&nbsp;ferritin,&nbsp;transferrin-m&aelig;tning, MCV og MCH<a href="EditorPage.aspx?da=core&amp;id=%7B84F24B5E-CB9C-48AE-9BC4-A1DCB7ED5C3F%7D&amp;ed=FIELD28217955628&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H28217955688&amp;us=sitecore%5Cneho&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Pfeiffer CM, Looker AC, Laboratory methodologies for indicators of iron status: strengths, limitations, and analytical challenges. Am J Clin Nutr 2017;106: 1606S-1614S" data-value-piped="Pfeiffer CM, Looker AC|Laboratory methodologies for indicators of iron status: strengths, limitations, and analytical challenges.|Am J Clin Nutr|2017|106|1606S-1614S|29070545" data-url="reference-link" data-pubmedid="29070545" title="Pfeiffer CM, Looker AC, Laboratory methodologies for indicators of iron status: strengths, limitations, and analytical challenges. Am J Clin Nutr 2017;106: 1606S-1614S"><sup>2</sup></a><sup>,</sup><a href="EditorPage.aspx?da=core&amp;id=%7B84F24B5E-CB9C-48AE-9BC4-A1DCB7ED5C3F%7D&amp;ed=FIELD1672578996&amp;vs&amp;la=da&amp;fld=%7B850D32D3-55A1-49E4-9CDF-F0C88D91563C%7D&amp;so=%2Fsitecore%2Fsystem%2FSettings%2FHtml%20Editor%20Profiles%2FRich%20Text%20LHPH&amp;di=0&amp;hdl=H1672579344&amp;mo&amp;pe=0&amp;fbd=1" data-type="journal-reference" data-value="Cotter J, Baldaia C, Ferreira M, Macedo G, Pedroto I, Diagnosis and treatment of iron-deficiency anemia in gastrointestinal bleeding: A systematic review. World J Gastroenterol 2020;26: 7242-7257" data-value-piped="Cotter J, Baldaia C, Ferreira M, Macedo G, Pedroto I|Diagnosis and treatment of iron-deficiency anemia in gastrointestinal bleeding: A systematic review.|World J Gastroenterol|2020|26|7242-7257|33362380" data-url="reference-link" data-pubmedid="33362380" title="Cotter J, Baldaia C, Ferreira M, Macedo G, Pedroto I, Diagnosis and treatment of iron-deficiency anemia in gastrointestinal bleeding: A systematic review. World J Gastroenterol 2020;26: 7242-7257"><sup>3</sup></a></li>
    <li>M&aring;ling af jern indg&aring;r ikke i DSGH's&nbsp;<a href="https://dsgh.dk/opdatering-af-guidelinen-om-udredning-og-behandling-af-uforklaret-anaemi-med-jernmangel-uden-synlig-bloedning/">guideline&nbsp;</a>(2023) for udredning af uforklaret an&aelig;mi</li>
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