proteinelektroforese-m-komponent (LH Indholdsside)

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      <HtmlField Name="PageContent"><![CDATA[<h2>Resum&eacute;</h2>
<ul>
    <li>M-komponent analyserne bruges i forbindelse med sygdomme udg&aring;ende fra B-lymfocytter (f.eks. myelomatose, MGUS (Monoklonal gammopathi af ukendt betydning), POEMS, lymfomer og kronisk lymfatisk leuk&aelig;mi)</li>
</ul>
<h2>Definition</h2>
<ul>
    <li>Unders&oslash;gelse for monoklonale immunglobuliner (M-komponent) er prim&aelig;rt&nbsp;indiceret ved mistanke om myelomatose/makroglobulin&aelig;mi samt monitorering af disse tilstande<a href="%20" title="Nilsson-Ehle P (red). Laurells klinisk kemi i praktisk medicin. 9. udg.. Lund: Studentlitteratur; 2012" data-url="reference-link" data-value-piped="Nilsson-Ehle P (red)|Laurells klinisk kemi i praktisk medicin. 9. udg.|Lund|Studentlitteratur|2012" data-value="Nilsson-Ehle P (red). Laurells klinisk kemi i praktisk medicin. 9. udg.. Lund: Studentlitteratur; 2012" data-type="book-reference">1</a><sup>,</sup><a href="%20" title="Lyngbye J, Kjær A, Ladefoged SA, Nissen PH. Lyngbyes laboratoriemedicin. 2 udg.. København: yt Nordisk Forlag Arnold Busck A/S; 2010" data-url="reference-link" data-value-piped="Lyngbye J, Kjær A, Ladefoged SA, Nissen PH|Lyngbyes laboratoriemedicin. 2 udg.|København|yt Nordisk Forlag Arnold Busck A/S|2010" data-value="Lyngbye J, Kjær A, Ladefoged SA, Nissen PH. Lyngbyes laboratoriemedicin. 2 udg.. København: yt Nordisk Forlag Arnold Busck A/S; 2010" data-type="book-reference">2</a> </li>
    <li>En laboratorieunders&oslash;gelse med en delvis adskillelse af diverse proteiner i&nbsp;serum (eller plasma), baseret p&aring; forskellene i proteinmolekylernes st&oslash;rrelse og elektriske ladninger, efterfulgt af en farvning og skanning for at kvantitere diverse fraktioner (toppe) </li>
    <li>Der findes en r&aelig;kke forskellige teknikker til form&aring;let, herunder is&aelig;r en teknik hvor elektroforesen kombineres med brugen af antistoffer mod bestemte proteiner eller typer af proteiner (immunfiksation)&nbsp;</li>
    <li>Figur 1 viser et typisk normalt fund, med en dominerende top for albumin og fire mindre toppe, som traditionelt er navngivet med gr&aelig;ske bogstaver og indeholder de forskellige andre proteiner i serum, fx:</li>
    <li>
    <img alt="SerumElektroforese" src="AABD9D3B5F0C49D9A48EF9BDF6A5F64A-200-0" text="SerumElektroforese" style="width: 200px;" height="0" width="200">
    <ul>
        <li>Alfa-1: Apolipoprotein A (som findes i HDL), alfa-1-glykoprotein og alfa-1-antitrypsin </li>
        <li>Alfa-2: alfa-2-makroglobulin, haptoglobin og ceruloplasmin </li>
        <li>Beta: Transferrin, apolipoprotein B (som findes i VLDL og LDL) og komplementproteinerne </li>
        <li>Gamma: Immunoglobulinerne, dvs. IgA, IgG og IgM, fibrinogen og CRP<a href=" " data-type="journal-reference" data-value="Willrich MA, Katzmann JA, Laboratory testing requirements for diagnosis and follow-up of multiple myeloma and related plasma cell dyscrasias.. Clin Chem Lab Med 2016;54: 907-19" data-value-piped="Willrich MA, Katzmann JA|Laboratory testing requirements for diagnosis and follow-up of multiple myeloma and related plasma cell dyscrasias.|Clin Chem Lab Med|2016|54|907-19|26509779" data-url="reference-link" data-pubmedid="26509779" title="Willrich MA, Katzmann JA, Laboratory testing requirements for diagnosis and follow-up of multiple myeloma and related plasma cell dyscrasias.. Clin Chem Lab Med 2016;54: 907-19">3</a></li>
    </ul>
    </li>
</ul>
<h2>Synonymer</h2>
<ul>
    <li>Myelomprotein,&nbsp;Paraprotein</li>
</ul>
<h2>Indikationer</h2>
<ul>
    <li>Mistanke om sygdom, hvor der forekommer, eller kan forekomme&nbsp;<a href="~/link.aspx?_id=6D79137757E34DCAB73DC6770A58A164&amp;_z=z">monoklonal gammopati</a>, dvs. et immunoglobulin stammende fra en enkelt klon af plasmaceller, hvilket is&aelig;r&nbsp;kan skyldes:
    <ul>
        <li><a href="~/link.aspx?_id=FEA337568D6743A3B6DAE50693FED1CA&amp;_z=z">Myelomatose</a></li>
        <li>MGUS (Monoklonal gammopathi af ukendt betydning)</li>
        <li><a href="~/link.aspx?_id=FDF394E65F43470091CA91D031F8AB3A&amp;_z=z">Waldenstr&oslash;m makroglobulin&aelig;mi</a>&nbsp;(monoklonalt IgM)</li>
    </ul>
    <ul>
        <li>Solit&aelig;rt myelom</li>
        <li>Tungk&aelig;desygdom (heavy chain disease)</li>
        <li>Plasmacelle leuk&aelig;mi</li>
        <li><a href="~/link.aspx?_id=25FC45605F1346C39C26A9873007A244&amp;_z=z">Non-Hodgkins lymfom</a></li>
        <li><a href="~/link.aspx?_id=17C7F13511584F368A3FC390D88772CD&amp;_z=z">Hodgkins lymfom</a></li>
        <li><a href="~/link.aspx?_id=0BF1F80D61F646868AE30BB4B8FCE16A&amp;_z=z">Kronisk lymfatisk leuk&aelig;mi</a></li>
        <li><a href="~/link.aspx?_id=24BFEFCFF9564F0C9EDE87811408712D&amp;_z=z">Prim&aelig;r amyloidose</a>&nbsp;(AL amyloidose)</li>
        <li>POEMS syndrom:&nbsp;<strong>P</strong>olyneuropati,&nbsp;<strong>o</strong>rganomegali,&nbsp;<strong>e</strong>ndokrinopati,&nbsp;<strong>m</strong>onoklonal gammopati og hudforandringer (<strong>s</strong>kin)&nbsp;</li>
    </ul>
    </li>
    <li>Ved mistanke om M-komponent-sygdom/myelomatose foretages f&oslash;lgende unders&oslash;gelse&nbsp;(&rdquo;screeningspr&oslash;ver&rdquo;, &rdquo;f&oslash;rste-gangspr&oslash;ver&rdquo;) ved indsendelse af serum.pr&oslash;ve
    <ul>
        <li>P-M-Komponent (NPU17675) </li>
        <li>Frie kappa&nbsp;k&aelig;der</li>
        <li>Frie lambda k&aelig;der og den beregnede kappa/lambda ratio (NPU19606, NPU19607 og&nbsp;NPU19608)</li>
        <li>Der b&oslash;r samtidig rekvireres immunologisk&nbsp;bestemt total IgG, IgA og IgM (NPU19814, NPU19795 og NPU19825)
        <ul>
            <li>M&aring;ling af immunglobuliner&nbsp;kan ikke erstatte M-komponent unders&oslash;gelse, men de er hensigtsm&aelig;ssige i forhold til b&aring;de den&nbsp;laboratoriem&aelig;ssige og den kliniske tolkning af serum M-komponent (se&nbsp;Dansk retningslinje for M-komponent analyser&nbsp;<a href="https://myeloma.hematology.dk/index.php/vejledninger-dmsg/442-m-komponent-analyser-3/file" data-type="other-reference" data-value="Dansk retningslinje for M-komponent analyser" data-url="https://myeloma.hematology.dk/index.php/vejledninger-dmsg/442-m-komponent-analyser-3/file" title="Dansk retningslinje for M-komponent analyser">4</a>)</li>
        </ul>
        </li>
    </ul>
    </li>
    <li>Kontrol af patienter i behandling for myelomatose eller Waldenstr&oslash;ms makroglobulin&aelig;mi</li>
    <li>&Aring;rlig kontrol af patienter med monoklonal gammopati af usikker signifikans (MGUS; se artiklen om&nbsp;<a href="~/link.aspx?_id=6D79137757E34DCAB73DC6770A58A164&amp;_z=z">monoklonal gammopati</a>), dvs. en prim&aelig;rt benign tilstand, som med tiden&nbsp;hos omkring 30 % dog udvikles til myelomatose, lymfom eller amyloidose</li>
</ul>
<h2>Fortolkninger</h2>
<ul>
    <li>B&aring;de vurderingen af elektroforesen og fortolkningen af resultatet er specialistopgaver
    <ul>
        <li>P&aring; laboratoriet er de kr&aelig;vende opgaver is&aelig;r knyttet til p&aring;visningen af sm&aring; M-komponenter med lokalisationer, der g&oslash;r, at de skjuler sig i andre toppe, samt at skelne M-komponenter fra andre abnorme eller us&aelig;dvanlige konfigurationer i elektroforesen</li>
    </ul>
    </li>
    <li>Resultaterne af unders&oslash;gelsen kan fortolkes sammen med resultater af andre biokemiske unders&oslash;gelser, is&aelig;r -
    <ul>
        <li><a href="~/link.aspx?_id=F115F1A4BE8648D5B5D0AB79A07629DD&amp;_z=z">P-Albumin</a></li>
        <li><a href="~/link.aspx?_id=27CA1321EFE8462E94C905F05A009637&amp;_z=z">P-Immunglobuliner (IgA, IgG og IgM)</a></li>
        <li>P-Kappa-k&aelig;der (frie), P-Lambda-k&aelig;der (frie) og ratio mellem disse
        <ul>
            <li>Analyserne anvendes is&aelig;r ved mistanke om s&aring;kaldt "non-sekretorisk" myelomatose, dvs. hvor der ikke med sikkerhed kan p&aring;vises en M-komponent, samt ved udredning af patienter med AL amyloidose og som prognostisk mark&oslash;r for malign udvikling hos patienter med MGUS</li>
        </ul>
        </li>
        <li>P-beta2-Mikroglobulin
        <ul>
            <li>Koncentrationen kan bruges som prognostisk mark&oslash;r for overlevelse ved myelomatose</li>
        </ul>
        </li>
    </ul>
    </li>
</ul>
<h2>Fejlkilder (og kilder til normal variation)</h2>
<ul>
    <li>M-komponent elektroforesen kan blive falsk negativ, n&aring;r M-komponenten er under detektionsgr&aelig;nsen</li>
    <li>Monoklonale antistoffer bruges til behandling af mange forskellige sygdomme og kan ved m&aring;ling af M-komponent i plasma optr&aelig;de som en nyopst&aring;et M-komponent.</li>
    <li>M&aring;ling af immunglobiner og frie lette k&aelig;der (kappa og lambda) er baseret immunassays og disse analyser er derfor f&oslash;lsomme for interferens, der kan p&aring;virke disse assays</li>
    <li>I meget sj&aelig;ldne tilf&aelig;lde kan M-komponenter af IgM-type ikke p&aring;vises og dermed ikke kvantificeres i kromatogrammet pga. cryoglobulin eller udf&aelig;ldning i forbindelse med elektroforese
    <ul>
        <li>Dette kan ofte elimineres ved at holde pr&oslash;ven varm (min. 37 grader) fra pr&oslash;vetagning til endt analysering.  I disse tilf&aelig;lde tages pr&oslash;ven som kryoglobulin</li>
    </ul>
    </li>
    <li>Hos nogle patienter ses i sj&aelig;ldne tilf&aelig;lde en transient M-komponent. Dette er ikke en m&aring;lefejl, men kan skyldes infektioner, autoimmune sygdomme og lign.&nbsp;</li>
</ul>
<h2>Biokemisk baggrund</h2>
<ul>
    <li> Antistoffer binder antigener, som normalt findes p&aring; overfladen af invaderende patogener og fremmede stoffer, hvilket starter processen med at neutralisere specifikke patogen</li>
    <li>Antistoffer, der kommer fra plasmaceller, udg&oslash;r den ene arm i det adaptive immunsystem</li>
    <li>Plasmaceller udvikler sig fra B-lymfocytter (dvs. B-celler)
    <ul>
        <li>Denne modningsudvikling stimuleres af T-lymfocytter</li>
        <li> Under denne proces re-arrangerer B-cellerne den del af deres genom, der koder for antistoffer, hvorved der dannes et specifikt antistof mod et patogen</li>
        <li> De humane antistoffer best&aring;r af to identiske tunge k&aelig;der; gamma (&gamma;), alfa (&alpha;), epsilon (&epsilon;), delta (&delta;), eller mu (&mu;) og to identiske lette k&aelig;der; kappa (&kappa;) eller lambda (&lambda;) undertyperne</li>
        <li> Antistoffer klassificeres som IgG, IgA, IgE, IgD og IgM ud fra, hvilken tung k&aelig;de der indg&aring;r &gamma;, &alpha;, &epsilon;, &delta; eller &mu;</li>
        <li>Normalt producerer plasmacellerne et lille overskud af de lette k&aelig;der i forhold til de tunge</li>
    </ul>
    </li>
    <li>Normalt producerer mange forskellige plasmacelle kloner hver deres immunoglobulin, uden at en klon / et antistof dominerer, og dette ses i elektroforesen gamma toppen, som har en p&aelig;n klokkeform (se figur 1)</li>
    <li>Ved transformation af en B-celle-klon vil den vokse og komme til at dominere, og det antistof, den producerer, vil ogs&aring; komme til at dominere, hvilket vil vise som en smal top (se figur 2)</li>
    <li>Myelomproteiner er overproducerede monoklonale proteiner og cirkulerer almindeligvis i blodet. De kan udskilles i urinen, hvilket er kendetegnene for plasmacelledyscrasier, herunder deres mest ondartede former, myelomatose, letk&aelig;dede multipelt myelom og plasmacelleleuk&aelig;mi
    <ul>
        <li>IgG-sekretorisk, IgA-sekretorisk og let-k&aelig;de-sekretorisk myelomatose repr&aelig;senterer henholdsvis 52 %, 21 % og 16 % af alle multipelt myelomtilf&aelig;lde; disse myelomer er forbundet med forskellige typer kromosomafvigelser og mutationer</li>
        <li>IgD-sekretorisk myelomatose forekommer kun i 1 % til 2 % af tilf&aelig;ldene af multipelt myelom og er almindeligvis forbundet med somatiske mutationer i genet, der koder for gV-regionen (dvs. den variable) af det monoklonale antistof</li>
        <li>IgE-sekretorisk myelomatose er meget sj&aelig;ldent og ofte forbundet med translokationer mellem q-armene af kromosom 11 og 14</li>
    </ul>
    </li>
</ul>
<h2>Pr&oslash;vetagning</h2>
<ul>
    <li>Veneblodpr&oslash;ve i r&oslash;r uden antikoagulans (t&oslash;rglas)</li>
    <li>Serum skal afpippeteres og kan sendes med almindelig post. Det er holdbart i 7 d&oslash;gn ved stuetemperatur</li>
    <li>Ved f&oslash;rste unders&oslash;gelse for M-komponent analyseres ogs&aring; for frie lette k&aelig;der i serum, som har erstattet screeningsm&aelig;ssig analysering af U-M-Komponent</li>
    <li>Der er i dag tilstr&aelig;kkelig evidens for anvendelsen af frie lette k&aelig;der til screening for letk&aelig;de-sygdom, og det store compliance problem ved U-M-Komponent undg&aring;s. Se retningslinjen&nbsp;<a href="https://www.hematology.dk/index.php/vejledninger/kliniske/mm/442-m-komponent-analyser-3/file">M-komponent analyser ved myelomatose</a></li>
    <li>Hvis letk&aelig;de-sygdom, er sandsynliggjort ved analysering af frie lette k&aelig;der, b&oslash;r der som led i udredningen af disse patienter suppleres med urin-unders&oslash;gelse for lette k&aelig;der<a href="https://myeloma.hematology.dk/index.php/vejledninger-dmsg/442-m-komponent-analyser-3/file" data-type="other-reference" data-value="Dansk retningslinje for M-komponent analyser" data-url="https://myeloma.hematology.dk/index.php/vejledninger-dmsg/442-m-komponent-analyser-3/file" title="Dansk retningslinje for M-komponent analyser">4</a></li>
</ul>
<h2>Referenceintervaller</h2>
<ul>
    <li>Plasma og urin: Ingen M-komponent p&aring;vist</li>
    <li>P-Kappa-k&aelig;de(Ig)(frit) (mg/L) 3,3-19,4 mg/L</li>
    <li>P-Lambda-k&aelig;de(Ig) frit (mg/L) 5,7-26,3 mg/L</li>
    <li>Kappa/Lambda-k&aelig;de(Ig) frit (ratio) 0,26-1,65</li>
    <li>OBS der kan v&aelig;r metodeafh&aelig;ngige forskelle</li>
</ul>
<h2>NPU-koder og -navne</h2>
<ul>
    <li>NPU17675&nbsp;</li>
    <li>Ved f&oslash;rstegangsanalyser (screening) bestilles ogs&aring; </li>
    <li>NPU19606&nbsp;</li>
    <li>NPU19607&nbsp;</li>
</ul>
<h3>Navne</h3>
<ul>
    <li><strong>Langt navn</strong>
    <ul>
        <li>NPU17675 P&mdash;M-komponent; arb.k.(proc.) = ?&nbsp;</li>
        <li>Ved f&oslash;rstegangsanalyser (screening) bestilles ogs&aring;&nbsp;</li>
        <li>NPU19606 P&mdash;Kappa-k&aelig;de(Ig)(frit); massek. = ? mg/L</li>
        <li>NPU19607 P&mdash;Lambda-k&aelig;de(Ig)(frit); massek. = ? mg/L</li>
    </ul>
    </li>
    <li><strong>Kort navn</strong>
    <ul>
        <li>M-komponent</li>
        <li>Ved f&oslash;rstegangsanalyser (screening) bestilles ogs&aring;&nbsp;</li>
        <li>Kappa-k&aelig;de(Ig)(frit)</li>
        <li>Lambda-k&aelig;de(Ig)(frit)</li>
    </ul>
    </li>
</ul>
<h2>Unders&oslash;gelsen</h2>
<ul>
    <li>Proceduren afh&aelig;nger af, om det er den f&oslash;rste unders&oslash;gelse ved mistanke om tilstedev&aelig;relsen af en M-komponent, eller en opf&oslash;lgende unders&oslash;gelse af en patient med en tidligere p&aring;vist M-komponent </li>
    <li>
    <strong>F&oslash;rste unders&oslash;gelse</strong>
    <ul>
        <li>Der foretages en elektroforese, og resultatet granskes for tilstedev&aelig;relsen af abnorme toppe
        <ul>
            <li>M-komponenter findes hyppigst i gamma-omr&aring;det, men kan ogs&aring; forekomme i beta- eller alfa-omr&aring;det</li>
        </ul>
        </li>
        <li>Hvis der ikke findes en M-komponent, s&aring; svarer laboratoriet fx "M-komponent = 0 g/L" </li>
        <li>Hvis der findes en M-komponent, eller hvis man er i tvivl, s&aring;:
        <ul>
            <li>(1) Bliver m&aelig;ngden af protein i komponenten beregnet og svaret som fx "M-komponent = X g/L" </li>
            <li>(2) Bliver der foretaget en immunfiksation eller tilsvarende til bestemmelse af immunglobulinets type, dvs. om de tunge k&aelig;der er af typen IgA, IgG eller IgM, eller i sj&aelig;ldne tilf&aelig;lde IgD eller IgE, og om de lette k&aelig;der er af typen Kappa eller Lambda</li>
        </ul>
        </li>
    </ul>
    </li>
    <li>
    <img alt="SerumElektroforese MKomponent" src="04B9B705720C4CF6AD2D244EA2CA2336-200-0" text="SerumElektroforese MKomponent" style="width: 200px;" height="0" width="200">
    <ul>
        <li>Figur 2 viser et eksempel p&aring; en meget stor M-komponent i gamma-omr&aring;det, som det typisk kan ses ved myelomatose</li>
        <li>M-komponent unders&oslash;gelse i serum b&oslash;r suppleres med analysering af frie lette k&aelig;der i serum idet letk&aelig;de-sygdom sj&aelig;ldent kan ses p&aring; serum-elektroforese</li>
        <li>Analysering af frie lette k&aelig;der i serum har i dag erstattet screeningsm&aelig;ssig analysering af U-M-Komponent i tidligere retningslinjer. Dog b&oslash;r der suppleres med en urinunders&oslash;gelse, hvis det er sandsynliggjort ved analysering af frie lette k&aelig;der i plasma</li>
    </ul>
    </li>
    <li>
    <strong>Opf&oslash;lgende unders&oslash;gelse (kontrol)</strong>
    <ul>
        <li>Der bliver kun udf&oslash;rt en elektroforese og en kvantitering af M-komponenten, hvis der f.eks. har v&aelig;ret usikkerhed med hensyn til typen </li>
        <li>Laboratoriet vil eventuelt oplyse, om der ses en betydende &aelig;ndring i koncentrationen af M-komponenten, fx svarende til mere end 25 % eller mere end 5 g/L</li>
    </ul>
    </li>
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]]></Media>
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